Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy

Jokeit H, Seitz RJ, Markowitsch HJ, Neumann N, Witte OW, Ebner A (1997)
BRAIN 120(12): 2283-2294.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ;
Abstract
Depressions of regional cerebral metabolism beyond the epileptogenic zone have been demonstrated in patients with intractable temporal lobe epilepsy. However their clinical relevance, and the causes of prefrontal metabolic asymmetries are less well understood. We investigated 96 temporal lobe epilepsy patients by FDG-PET and neuropsychological assessment who had a corresponding unilateral temporal hypometabolism, left hemisphere speech dominance, full scale IQ of >70 and no extratemporal lesion in MRIs. The regional glucose metabolism was determined in each patient in homologous regions including prefrontal cortex, and normalized to whole brain metabolism. Regional differences of >10% were regarded as asymmetrical. Prefrontal metabolic asymmetries were more frequent in patients with left temporal lobe epilepsy (21 left, six right) and a history of secondarily generalized seizures. A multivariate analysis of variance revealed a main effect for prefrontal metabolic asymmetry on neuropsychological 'frontal lobe measures', including verbal and performance intelligence measures. Prefrontal metabolic asymmetry was not related to 'measures of episodic memory', presence of psychiatric symptoms or frontal interictal epileptiform discharges. We conclude that prefrontal metabolic asymmetry is associated with cognitive impairment. Patients with temporal lobe epilepsy of the left speech dominant hemisphere and a history of secondarily generalized seizures are at considerable risk of developing prefrontal metabolic asymmetry.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Jokeit H, Seitz RJ, Markowitsch HJ, Neumann N, Witte OW, Ebner A. Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy. BRAIN. 1997;120(12):2283-2294.
Jokeit, H., Seitz, R. J., Markowitsch, H. J., Neumann, N., Witte, O. W., & Ebner, A. (1997). Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy. BRAIN, 120(12), 2283-2294. doi:10.1093/brain/120.12.2283
Jokeit, H., Seitz, R. J., Markowitsch, H. J., Neumann, N., Witte, O. W., and Ebner, A. (1997). Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy. BRAIN 120, 2283-2294.
Jokeit, H., et al., 1997. Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy. BRAIN, 120(12), p 2283-2294.
H. Jokeit, et al., “Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy”, BRAIN, vol. 120, 1997, pp. 2283-2294.
Jokeit, H., Seitz, R.J., Markowitsch, H.J., Neumann, N., Witte, O.W., Ebner, A.: Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy. BRAIN. 120, 2283-2294 (1997).
Jokeit, H, Seitz, RJ, Markowitsch, Hans J., Neumann, N, Witte, OW, and Ebner, A. “Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy”. BRAIN 120.12 (1997): 2283-2294.
This data publication is cited in the following publications:
This publication cites the following data publications:

93 Citations in Europe PMC

Data provided by Europe PubMed Central.

Reduced glucose metabolism in neocortical network nodes remote from hypothalamic hamartomas reflects cognitive impairment.
Wagner K, Schulze-Bonhage A, Urbach H, Trippel M, Spehl TS, Buschmann F, Metternich B, Ofer I, Meyer PT, Frings L., Epilepsia 58 Suppl 2(), 2017
PMID: 28591477
Left or right? Lateralizing temporal lobe epilepsy by dynamic amygdala fMRI.
Ives-Deliperi V, Butler JT, Jokeit H., Epilepsy Behav 70(Pt A), 2017
PMID: 28427018
Recurring Functional Interactions Predict Network Architecture of Interictal and Ictal States in Neocortical Epilepsy.
Khambhati AN, Bassett DS, Oommen BS, Chen SH, Lucas TH, Davis KA, Litt B., eNeuro 4(1), 2017
PMID: 28303256
Hippocampus-associated causal network of structural covariance measuring structural damage progression in temporal lobe epilepsy.
Zhang Z, Liao W, Xu Q, Wei W, Zhou HJ, Sun K, Yang F, Mantini D, Ji X, Lu G., Hum Brain Mapp 38(2), 2017
PMID: 27677885
Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy.
Takaya S, Liu H, Greve DN, Tanaka N, Leveroni C, Cole AJ, Stufflebeam SM., Hum Brain Mapp 37(12), 2016
PMID: 27452151
Influence of Formal Education on Cognitive Reserve in Patients with Multiple Sclerosis.
Luerding R, Gebel S, Gebel EM, Schwab-Malek S, Weissert R., Front Neurol 7(), 2016
PMID: 27065941
Extratemporal abnormalities in phosphorus magnetic resonance spectroscopy of patients with mesial temporal sclerosis.
Park EJ, Otaduy MC, de Lyra KP, Andrade CS, Castro LH, Passarelli V, Valerio RM, Jorge CL, Tsunemi MH, Leite Cda C., Arq Neuropsiquiatr 74(2), 2016
PMID: 26982984
Correlation between interictal cerebral glucose hypometabolism and IQ in children with epilepsy.
Tang Z, Chen Z, Zhai Q, Hao Y, Zhang Y, Zeng X., Epilepsy Behav 31(), 2014
PMID: 24291524
Impaired self-referential processing in mesial temporal lobe epilepsy: a functional MRI study.
Yuan C, Zhang Z, Wang Z, Liao W, Chen G, Northoff G, Lu G., Neurosci. Lett. 555(), 2013
PMID: 24090819
[Cognition and epilepsies].
Stefan H, Pauli E., Nervenarzt 79 Suppl 2(), 2008
PMID: 18685823
[Epilepsy: role of neuropsychological evaluation].
Samson S., Neurochirurgie 54(3), 2008
PMID: 18440032
Epilepsy surgery in professional musicians: subjective and objective reports of three cases.
Schulz R, Horstmann S, Jokeit H, Woermann FG, Ebner A., Epilepsy Behav 7(3), 2005
PMID: 16143569
[Brain hypometabolism in patients with mesial-temporal sclerosis demonstrated by FDG-PET]
Duarte PS, Zhuang H, King D, Alavi A., Arq Neuropsiquiatr 58(3B), 2000
PMID: 11018824

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 9448582
PubMed | Europe PMC

Search this title in

Google Scholar