Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo

Sepper R, Konttinen YT, Buo L, Eklund KK, Lauhio A, Sorsa T, Tschesche H, Aasen AO, Sillastu H (1997)
EUROPEAN RESPIRATORY JOURNAL 10(12): 2788-2793.

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We attempted to study the possible relationships between neutrophiltype procollagenase/pro-matrix metalloproteinase (MMP-8) and the serine proteinases plasmin, cathepsin G and tryptase in bronchiectasis. The presence of the plasmin/piasminogen system and plasmin-, cathepsin G-and tryptase-like activities were compared to the activity of endogenously activated MMP-8 in bronchoalveolar lavage (BAL) fluid in 38 bronchiectasis patients and in 14 healthy controls by means of immunohistochemistry, Western-blot and substratebased functional assays, In contrast to cathepsin G-and tryptase-like activities, the plasmin/plasminogen activator system in BAL fluid was observed to have a relatively weak activation stage and no correlation with disease severity, Neither plasmin-like activities nor concentrations of plasminogen activators from the bronchiectatic patients differed significantly from the values of health. controls, Immunolocation of plasminogen activator inhibitor-1 showed a marked, but not significant, increase in bronchiectatic lung as compared to controls, In contrast to cathepsin G-and tryptase-like activities,,vith their strong and significant correlation with endogenously activated collagenase (r=0.9; p=0.0001; and r=0.6; p=0.03, respectively), no correlations were observed between plasmin-like and endogenously activated collagenase(r=0.3; p=0.2) in bronchiectasis. These findings suggest that cathepsin G-and tryptase-like activities may act as potent pro-matrix metalloproteinase-8 activators in patients with bronrhiectasis, whereas the plasminogen activator/plasmin cascade was shown to be down-regulated.
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Sepper R, Konttinen YT, Buo L, et al. Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL. 1997;10(12):2788-2793.
Sepper, R., Konttinen, Y. T., Buo, L., Eklund, K. K., Lauhio, A., Sorsa, T., Tschesche, H., et al. (1997). Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL, 10(12), 2788-2793.
Sepper, R., Konttinen, Y. T., Buo, L., Eklund, K. K., Lauhio, A., Sorsa, T., Tschesche, H., Aasen, A. O., and Sillastu, H. (1997). Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL 10, 2788-2793.
Sepper, R., et al., 1997. Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL, 10(12), p 2788-2793.
R. Sepper, et al., “Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo”, EUROPEAN RESPIRATORY JOURNAL, vol. 10, 1997, pp. 2788-2793.
Sepper, R., Konttinen, Y.T., Buo, L., Eklund, K.K., Lauhio, A., Sorsa, T., Tschesche, H., Aasen, A.O., Sillastu, H.: Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL. 10, 2788-2793 (1997).
Sepper, R, Konttinen, YT, Buo, L, Eklund, KK, Lauhio, A, Sorsa, T, Tschesche, Harald, Aasen, AO, and Sillastu, H. “Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo”. EUROPEAN RESPIRATORY JOURNAL 10.12 (1997): 2788-2793.
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Mechanisms of liver fibrosis.
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