Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo

Sepper R, Konttinen YT, Buo L, Eklund KK, Lauhio A, Sorsa T, Tschesche H, Aasen AO, Sillastu H (1997)
EUROPEAN RESPIRATORY JOURNAL 10(12): 2788-2793.

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We attempted to study the possible relationships between neutrophiltype procollagenase/pro-matrix metalloproteinase (MMP-8) and the serine proteinases plasmin, cathepsin G and tryptase in bronchiectasis. The presence of the plasmin/piasminogen system and plasmin-, cathepsin G-and tryptase-like activities were compared to the activity of endogenously activated MMP-8 in bronchoalveolar lavage (BAL) fluid in 38 bronchiectasis patients and in 14 healthy controls by means of immunohistochemistry, Western-blot and substratebased functional assays, In contrast to cathepsin G-and tryptase-like activities, the plasmin/plasminogen activator system in BAL fluid was observed to have a relatively weak activation stage and no correlation with disease severity, Neither plasmin-like activities nor concentrations of plasminogen activators from the bronchiectatic patients differed significantly from the values of health. controls, Immunolocation of plasminogen activator inhibitor-1 showed a marked, but not significant, increase in bronchiectatic lung as compared to controls, In contrast to cathepsin G-and tryptase-like activities,,vith their strong and significant correlation with endogenously activated collagenase (r=0.9; p=0.0001; and r=0.6; p=0.03, respectively), no correlations were observed between plasmin-like and endogenously activated collagenase(r=0.3; p=0.2) in bronchiectasis. These findings suggest that cathepsin G-and tryptase-like activities may act as potent pro-matrix metalloproteinase-8 activators in patients with bronrhiectasis, whereas the plasminogen activator/plasmin cascade was shown to be down-regulated.
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Sepper R, Konttinen YT, Buo L, et al. Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL. 1997;10(12):2788-2793.
Sepper, R., Konttinen, Y. T., Buo, L., Eklund, K. K., Lauhio, A., Sorsa, T., Tschesche, H., et al. (1997). Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL, 10(12), 2788-2793. doi:10.1183/09031936.97.10122788
Sepper, R., Konttinen, Y. T., Buo, L., Eklund, K. K., Lauhio, A., Sorsa, T., Tschesche, H., Aasen, A. O., and Sillastu, H. (1997). Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL 10, 2788-2793.
Sepper, R., et al., 1997. Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL, 10(12), p 2788-2793.
R. Sepper, et al., “Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo”, EUROPEAN RESPIRATORY JOURNAL, vol. 10, 1997, pp. 2788-2793.
Sepper, R., Konttinen, Y.T., Buo, L., Eklund, K.K., Lauhio, A., Sorsa, T., Tschesche, H., Aasen, A.O., Sillastu, H.: Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. EUROPEAN RESPIRATORY JOURNAL. 10, 2788-2793 (1997).
Sepper, R, Konttinen, YT, Buo, L, Eklund, KK, Lauhio, A, Sorsa, T, Tschesche, Harald, Aasen, AO, and Sillastu, H. “Potentiative effects of neutral proteinases in an inflamed lung: Relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo”. EUROPEAN RESPIRATORY JOURNAL 10.12 (1997): 2788-2793.
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