Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus)
Winterfeld KT, Teuchert-Noodt G, Dawirs RR (1998)
JOURNAL OF NEUROSCIENCE RESEARCH 52(2): 201-209.
Download
No fulltext has been uploaded. References only!
Journal Article
| Original Article
| Published
| English
No fulltext has been uploaded
Author
Department
Abstract
Male gerbils (Meriones unguiculatus) were bred and reared either grouped under enriched environmental conditions or isolated under impoverished environmental conditions. The objective of the present study was to examine the influence of social environment on structural and functional ontogeny of the medial prefrontal cortex (mPFC), In this respect, we investigated the maturation of both prefrontal dopamine (DA) innervation and working memory. For that purpose, at the age of postnatal day 90, prefrontal DA fibers were stained immunocytochemically using an antibody against glutaraldehyde-conjugated DA and innervation density was determined by means of a computer controlled program for image analysis. In order to evaluate environmental effects on working memory, 90-day-old gerbils were tested for y-maze delayed alternation, It was found that, isolation produced a significant and severe restraint of the maturation of prefrontal DA innervation, leading to fiber densities which were 56% below those in group-reared gerbils, Isolation also induced a significant impairment of delayed alternation performance on the y-maze indicating that obvious deficits in working memory had developed under restricted rearing conditions. The present results are discussed with regard to activity-dependent postnatal maturation of the cortex and adaptive neuroplasticity. (C) 1998 Wiley-Liss, Inc.
Keywords
Publishing Year
ISSN
eISSN
PUB-ID
Cite this
Winterfeld KT, Teuchert-Noodt G, Dawirs RR. Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus). JOURNAL OF NEUROSCIENCE RESEARCH. 1998;52(2):201-209.
Winterfeld, K. T., Teuchert-Noodt, G., & Dawirs, R. R. (1998). Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus). JOURNAL OF NEUROSCIENCE RESEARCH, 52(2), 201-209. doi:10.1002/(SICI)1097-4547(19980415)52:2<201::AID-JNR8>3.0.CO;2-E
Winterfeld, K. T., Teuchert-Noodt, G., and Dawirs, R. R. (1998). Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus). JOURNAL OF NEUROSCIENCE RESEARCH 52, 201-209.
Winterfeld, K.T., Teuchert-Noodt, G., & Dawirs, R.R., 1998. Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus). JOURNAL OF NEUROSCIENCE RESEARCH, 52(2), p 201-209.
K.T. Winterfeld, G. Teuchert-Noodt, and R.R. Dawirs, “Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus)”, JOURNAL OF NEUROSCIENCE RESEARCH, vol. 52, 1998, pp. 201-209.
Winterfeld, K.T., Teuchert-Noodt, G., Dawirs, R.R.: Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus). JOURNAL OF NEUROSCIENCE RESEARCH. 52, 201-209 (1998).
Winterfeld, KT, Teuchert-Noodt, Gertraud, and Dawirs, RR. “Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus)”. JOURNAL OF NEUROSCIENCE RESEARCH 52.2 (1998): 201-209.
This data publication is cited in the following publications:
This publication cites the following data publications:
57 Citations in Europe PMC
Data provided by Europe PubMed Central.
Mother's voice "buffers" separation-induced receptor changes in the prefrontal cortex of octodon degus.
Ziabreva I, Schnabel R, Poeggel G, Braun K., Neuroscience 119(2), 2003
PMID: 12770557
Ziabreva I, Schnabel R, Poeggel G, Braun K., Neuroscience 119(2), 2003
PMID: 12770557
Neonatal development of projections from the basolateral amygdala to prefrontal, striatal, and thalamic structures in the rat.
Bouwmeester H, Wolterink G, van Ree JM., J Comp Neurol 442(3), 2002
PMID: 11774339
Bouwmeester H, Wolterink G, van Ree JM., J Comp Neurol 442(3), 2002
PMID: 11774339
Differential environment alters ontogeny of dopamine innervation of the orbital prefrontal cortex in gerbils.
Neddens J, Brandenburg K, Teuchert-Noodt G, Dawirs RR., J Neurosci Res 63(2), 2001
PMID: 11169631
Neddens J, Brandenburg K, Teuchert-Noodt G, Dawirs RR., J Neurosci Res 63(2), 2001
PMID: 11169631
Maternal separation followed by early social deprivation affects the development of monoaminergic fiber systems in the medial prefrontal cortex of Octodon degus.
Braun K, Lange E, Metzger M, Poeggel G., Neuroscience 95(1), 2000
PMID: 10619487
Braun K, Lange E, Metzger M, Poeggel G., Neuroscience 95(1), 2000
PMID: 10619487
Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood.
Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Rüther E, Huether G., Brain Res Dev Brain Res 119(2), 2000
PMID: 10675775
Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Rüther E, Huether G., Brain Res Dev Brain Res 119(2), 2000
PMID: 10675775
The stress-reaction process and the adaptive modification and reorganization of neuronal networks.
Huether G, Doering S, Rüger U, Rüther E, Schüssler G., Psychiatry Res 87(1), 1999
PMID: 10512158
Huether G, Doering S, Rüger U, Rüther E, Schüssler G., Psychiatry Res 87(1), 1999
PMID: 10512158
Early social isolation decreases the expression of calbindin D-28k in rat cerebellar Purkinje cells.
Pascual R, Verdú E, Valero A, Navarro X., Neurosci Lett 272(3), 1999
PMID: 10505608
Pascual R, Verdú E, Valero A, Navarro X., Neurosci Lett 272(3), 1999
PMID: 10505608
Export
0 Marked PublicationsWeb of Science
View record in Web of Science®Sources
PMID: 9579410
PubMed | Europe PMC