A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates

Witt CC, Olivieri N, Centner T, Kolmerer B, Millevoi S, Morell J, Labeit D, Labeit S, Jockusch H, Pastore A (1998)
Journal of structural biology 122(1-2): 206-215.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ;
Abstract
Titin is a >3000-kDa large filamentous protein of vertebrate-striated muscle, and single titin molecules extend from the Z disc to the M line. In its I-band section, titin behaves extensible and is responsible for myofibrillar passive tension during stretch. However; details of the molecular basis of titin's elasticity are not known. We have compared the motif sequences of titin elastic elements from different vertebrate species and from different regions of the molecule. The I-band titin Ig repeats that are expressed in the stiff cardiac muscle and those that are tissue-specifically expressed in more elastic skeletal muscles represent distinct subgroups. Within the tissue-specifically expressed Ig repeats, a super-repeat structure is found. For the PEVK titin sequences, we surveyed interspecies conservation by hybridization experiments. The sequences of the titin gene which code for the C-terminal region of the PEVK domain are conserved in the genomes of a larger variety of vertebrate, whereas the N-terminal PEVK sequences are more divergent. Future comparisons of titin gene sequences from different vertebrates may improve our understanding of how titin contributes to species diversity of myofibrillar elasticity. Within one species, different classes of Ig repeat families may contribute to elastic diversity of the titin spring in different segments. (C) 1998 Academic Press.
Publishing Year
ISSN
PUB-ID

Cite this

Witt CC, Olivieri N, Centner T, et al. A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates. Journal of structural biology. 1998;122(1-2):206-215.
Witt, C. C., Olivieri, N., Centner, T., Kolmerer, B., Millevoi, S., Morell, J., Labeit, D., et al. (1998). A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates. Journal of structural biology, 122(1-2), 206-215.
Witt, C. C., Olivieri, N., Centner, T., Kolmerer, B., Millevoi, S., Morell, J., Labeit, D., Labeit, S., Jockusch, H., and Pastore, A. (1998). A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates. Journal of structural biology 122, 206-215.
Witt, C.C., et al., 1998. A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates. Journal of structural biology, 122(1-2), p 206-215.
C.C. Witt, et al., “A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates”, Journal of structural biology, vol. 122, 1998, pp. 206-215.
Witt, C.C., Olivieri, N., Centner, T., Kolmerer, B., Millevoi, S., Morell, J., Labeit, D., Labeit, S., Jockusch, H., Pastore, A.: A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates. Journal of structural biology. 122, 206-215 (1998).
Witt, CC, Olivieri, N, Centner, T, Kolmerer, B, Millevoi, S, Morell, J, Labeit, D, Labeit, S, Jockusch, Harald, and Pastore, A. “A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates”. Journal of structural biology 122.1-2 (1998): 206-215.
This data publication is cited in the following publications:
This publication cites the following data publications:

26 Citations in Europe PMC

Data provided by Europe PubMed Central.

X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1).
Manjasetty BA, Niesen FH, Scheich C, Roske Y, Goetz F, Behlke J, Sievert V, Heinemann U, Bussow K., BMC Struct. Biol. 5(), 2005
PMID: 16354304

41 References

Data provided by Europe PubMed Central.

The elastic I-band region of titin is assembled in a "modular" fashion by weakly interacting Ig-like domains.
Politou AS, Gautel M, Improta S, Vangelista L, Pastore A., J. Mol. Biol. 255(4), 1996
PMID: 8568900
Reversible unfolding of individual titin immunoglobulin domains by AFM.
Rief M, Gautel M, Oesterhelt F, Fernandez JM, Gaub HE., Science 276(5315), 1997
PMID: 9148804
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.
Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N., Science 230(4732), 1985
PMID: 2999980
Titin unfolding energy and elasticity
Soteriou, Proc. R. Soc. London B. Biol. Sci. 254(), 1993
Electron microscopic filament lengths of connection and its fragments.
Suzuki J, Kimura S, Maruyama K., J. Biochem. 116(2), 1994
PMID: 7822261
Molecular characterization of avian muscle titin.
Tan KO, Sater GR, Myers AM, Robson RM, Huiatt TW., J. Biol. Chem. 268(30), 1993
PMID: 8226799
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
Thompson, Nucleic Acids Res. (), 1997
Titin and nebulin: protein rulers in muscle?
Trinick J., Trends Biochem. Sci. 19(10), 1994
PMID: 7817397
Interaction between titin and thin filaments in intact cardiac muscle.
Trombitas K, Greaser ML, Pollack GH., J. Muscle Res. Cell. Motil. 18(3), 1997
PMID: 9172076
Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments.
Trombitas K, Greaser M, Labeit S, Jin JP, Kellermayer M, Helmes M, Granzier H., J. Cell Biol. 140(4), 1998
PMID: 9472037
Elasticity and unfolding of single molecules of the giant muscle protein titin.
Tskhovrebova L, Trinick J, Sleep JA, Simmons RM., Nature 387(6630), 1997
PMID: 9153398
A 11.5-kb 5'-terminal cDNA sequence of chicken breast muscle connectin/titin reveals its Z line binding region.
Yajima H, Ohtsuka H, Kawamura Y, Kume H, Murayama T, Abe H, Kimura S, Maruyama K., Biochem. Biophys. Res. Commun. 223(1), 1996
PMID: 8660363
Titin: major myofibrillar components of striated muscle.
Wang K, McClure J, Tu A., Proc. Natl. Acad. Sci. U.S.A. 76(8), 1979
PMID: 291034

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 9724622
PubMed | Europe PMC

Search this title in

Google Scholar