Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes

Yin H, Cukurcam S, Betzendahl I, Adler ID, Eichenlaub-Ritter U (1998)
CHROMOSOMA 107(6-7): 514-522.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ;
Abstract / Bemerkung
Consumption of trichlorfon-poisoned fish by women in a small Hungarian village has been associated with trisomy resulting from an error of meiosis B in oogenesis. We therefore examined mouse oocytes exposed for 3 h during fertilization to 50 mu g/ml trichlorfon. Spindle morphology was not visibly altered by the pesticide. Chromosomes segregated normally at anaphase II with no induction of aneuploidy. However, formation of a spindle was disturbed in many oocytes resuming meiosis I in the presence of trichlorfon. In spite of the spindle aberrations and the failure of bivalents to align properly at the equator, oocytes did not become meiotically arrested but progressed to metaphase B. At this stage, spindles were highly abnormal, and chromosomes were often totally unaligned, unattached or dispersed on the elongated and disorganized spindle. By causing spindle aberrations and influencing chromosome congression, trichlorfon appears, therefore, to predispose mammalian oocytes to random chromosome segregation, especially when they undergo a first division and develop to metaphase II during exposure. This is the first case in which environmentally induced human trisomy can be correlated with spindle aberrations induced by chemical exposure. Our observations suggest that oocytes may not possess a checkpoint sensing displacement of chromosomes from the equator at meiosis I and may therefore be prone to nondisjunction.
Erscheinungsjahr
Zeitschriftentitel
CHROMOSOMA
Band
107
Zeitschriftennummer
6-7
Seite
514-522
ISSN
eISSN
PUB-ID

Zitieren

Yin H, Cukurcam S, Betzendahl I, Adler ID, Eichenlaub-Ritter U. Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes. CHROMOSOMA. 1998;107(6-7):514-522.
Yin, H., Cukurcam, S., Betzendahl, I., Adler, I. D., & Eichenlaub-Ritter, U. (1998). Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes. CHROMOSOMA, 107(6-7), 514-522. doi:10.1007/s004120050337
Yin, H., Cukurcam, S., Betzendahl, I., Adler, I. D., and Eichenlaub-Ritter, U. (1998). Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes. CHROMOSOMA 107, 514-522.
Yin, H., et al., 1998. Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes. CHROMOSOMA, 107(6-7), p 514-522.
H. Yin, et al., “Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes”, CHROMOSOMA, vol. 107, 1998, pp. 514-522.
Yin, H., Cukurcam, S., Betzendahl, I., Adler, I.D., Eichenlaub-Ritter, U.: Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes. CHROMOSOMA. 107, 514-522 (1998).
Yin, H, Cukurcam, S, Betzendahl, I, Adler, ID, and Eichenlaub-Ritter, Ursula. “Trichlorfon exposure, spindle aberrations and nondisjunction in mammalian oocytes”. CHROMOSOMA 107.6-7 (1998): 514-522.

30 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Manipulating the human embryo: cell cycle checkpoint controls.
Fulka J, Tesarík J, Loi P, Moor RM., Cloning 2(1), 2000
PMID: 16218841
Cerebellum as a target for toxic substances.
Fonnum F, Lock EA., Toxicol Lett 112-113(), 2000
PMID: 10720707
Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice.
Woods LM, Hodges CA, Baart E, Baker SM, Liskay M, Hunt PA., J Cell Biol 145(7), 1999
PMID: 10385520
Nuclear and cytoplasmic maturation of mouse oocytes after treatment with synthetic meiosis-activating sterol in vitro.
Hegele-Hartung C, Kuhnke J, Lessl M, Grøndahl C, Ottesen J, Beier HM, Eisner S, Eichenlaub-Ritter U., Biol Reprod 61(5), 1999
PMID: 10529286

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 9914385
PubMed | Europe PMC

Suchen in

Google Scholar