Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene

Kamp P-B, Ragg H (1999)
GENE 229(1-2): 137-144.

Journal Article | Published | English

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Abstract
The genomic organization of the heparin cofactor II (HCII) gene from rat and mouse was investigated and compared with their human counterpart. The genes share a common core structure consisting of five exons interrupted by four introns, but the mouse and rat gene reveal individual additional features. A unique differentially spliced exon is present in the 5'-untranslated region of the rat gene, which most probably has arisen de novo by point mutations in intronic sequences of the ancestor gene. In the mouse HCII gene, a novel intron/exon boundary has been created due to the presence of an additional DNA segment, which simultaneously provides a 3'-splice site and a polypyrimidine stretch leading to an alternatively used exon of increased size. Our data suggest that, in contrast to most other mammalian genes, the exon/intron pattern of the gene coding for HCII is in dynamic evolution. (C) 1999 Elsevier Science B.V. All rights reserved.
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Kamp P-B, Ragg H. Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE. 1999;229(1-2):137-144.
Kamp, P. - B., & Ragg, H. (1999). Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE, 229(1-2), 137-144.
Kamp, P. - B., and Ragg, H. (1999). Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE 229, 137-144.
Kamp, P.-B., & Ragg, H., 1999. Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE, 229(1-2), p 137-144.
P.-B. Kamp and H. Ragg, “Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene”, GENE, vol. 229, 1999, pp. 137-144.
Kamp, P.-B., Ragg, H.: Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE. 229, 137-144 (1999).
Kamp, Paul-Bertram, and Ragg, Hermann. “Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene”. GENE 229.1-2 (1999): 137-144.
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PMID: 17549254

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