Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment

Winkler M, Fischer DC, Ruck P, Marx T, Kaiserling E, Oberpichler A, Tschesche H, Rath W (1999)
HUMAN REPRODUCTION 14(4): 1096-1100.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ;
Abstract
A relationship was sought between the tissue concentrations of interleukin (IL)-8, matrix metalloproteinase (MMP)-8 and MMP-9, and the numbers of the various leukocytes infiltrating the lower uterine segment stroma during parturition, Biopsy specimens of the lower uterine segment mere obtained from 63 women undergoing Caesarean section at various stages of cervical dilatation at term. The concentrations of IL-8, MMP-8 and MMP-9 were determined with enzyme-linked immunosorbent assays, and the leukocytes mere quantified immunohistochemically. The median IL-8 concentration (pg/mg total protein) rose significantly from 17.2 at <2 cm dilatation, to 26.5 at 2 to <4 cm dilatation, and 1954.0 at 4-6 cm dilatation, and remained at approximately this concentration at >6 cm dilatation, The median MMP-8 concentration (ng/mg total protein) increased significantly from 32.2 at <2 cm dilatation to 114.2 at >6 cm dilatation. The median MMP-9 concentration (ng/mg total protein) rose significantly from 15.4 at <2 cm dilatation to 102.1 at >6 cm dilatation. The number of neutrophils was significantly higher at 4-6 cm and >6 cm dilatation than at >2 cm, reaching maximum values at >6 cm dilatation, The findings in this study support the hypothesis that IL-8-induced infiltration of the cervical stroma by neutrophils and subsequent release of proteinases may play a key role in parturition.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Winkler M, Fischer DC, Ruck P, et al. Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION. 1999;14(4):1096-1100.
Winkler, M., Fischer, D. C., Ruck, P., Marx, T., Kaiserling, E., Oberpichler, A., Tschesche, H., et al. (1999). Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION, 14(4), 1096-1100.
Winkler, M., Fischer, D. C., Ruck, P., Marx, T., Kaiserling, E., Oberpichler, A., Tschesche, H., and Rath, W. (1999). Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION 14, 1096-1100.
Winkler, M., et al., 1999. Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION, 14(4), p 1096-1100.
M. Winkler, et al., “Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment”, HUMAN REPRODUCTION, vol. 14, 1999, pp. 1096-1100.
Winkler, M., Fischer, D.C., Ruck, P., Marx, T., Kaiserling, E., Oberpichler, A., Tschesche, H., Rath, W.: Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION. 14, 1096-1100 (1999).
Winkler, M, Fischer, DC, Ruck, P, Marx, T, Kaiserling, E, Oberpichler, A, Tschesche, Harald, and Rath, W. “Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment”. HUMAN REPRODUCTION 14.4 (1999): 1096-1100.
This data publication is cited in the following publications:
This publication cites the following data publications:

31 Citations in Europe PMC

Data provided by Europe PubMed Central.

Neutrophil migration into the placenta: Good, bad or deadly?
Giaglis S, Stoikou M, Grimolizzi F, Subramanian BY, van Breda SV, Hoesli I, Lapaire O, Hasler P, Than NG, Hahn S., Cell Adh Migr 10(1-2), 2016
PMID: 26933824
The effect of a Foley catheter balloon on cervical ripening.
Lim SY, Kim YH, Kim CH, Cho MK, Kim JW, Kang WD, Kim SM, Cho HY, Ahn KY, Lee KH, Song TB., J Obstet Gynaecol 33(8), 2013
PMID: 24219725
Alterations in the cellular component of the maternal immune system in a murine preterm delivery model.
Evangelinakis NE, Polyzou EN, Salamalekis GE, Kotsaki AJ, Chrelias CG, Giamarellos-Bourboulis EJ, Kassanos DP., J. Matern. Fetal. Neonatal. Med. 26(10), 2013
PMID: 23311765
Are alterations in plasma protease concentrations during labor associated with poor obstetric outcomes?
Knight RL, Rice GE, Permezel M., Am. J. Obstet. Gynecol. 193(1), 2005
PMID: 16021091
Interleukin-8 can stimulate progesterone secretion from a human trophoblast cell line, BeWo.
Tsui KH, Chen LY, Shieh ML, Chang SP, Yuan CC, Li HY., In Vitro Cell. Dev. Biol. Anim. 40(10), 2004
PMID: 15780010
Localization and quantification of adhesion molecule expression in the lower uterine segment during premature labor.
Fischer DC, Winkler M, Ruck P, Poth D, Kemp B, Rath W., J Perinat Med 29(6), 2001
PMID: 11776680

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 10221247
PubMed | Europe PMC

Search this title in

Google Scholar