Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment

Winkler M, Fischer DC, Ruck P, Marx T, Kaiserling E, Oberpichler A, Tschesche H, Rath W (1999)
HUMAN REPRODUCTION 14(4): 1096-1100.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
A relationship was sought between the tissue concentrations of interleukin (IL)-8, matrix metalloproteinase (MMP)-8 and MMP-9, and the numbers of the various leukocytes infiltrating the lower uterine segment stroma during parturition, Biopsy specimens of the lower uterine segment mere obtained from 63 women undergoing Caesarean section at various stages of cervical dilatation at term. The concentrations of IL-8, MMP-8 and MMP-9 were determined with enzyme-linked immunosorbent assays, and the leukocytes mere quantified immunohistochemically. The median IL-8 concentration (pg/mg total protein) rose significantly from 17.2 at <2 cm dilatation, to 26.5 at 2 to <4 cm dilatation, and 1954.0 at 4-6 cm dilatation, and remained at approximately this concentration at >6 cm dilatation, The median MMP-8 concentration (ng/mg total protein) increased significantly from 32.2 at <2 cm dilatation to 114.2 at >6 cm dilatation. The median MMP-9 concentration (ng/mg total protein) rose significantly from 15.4 at <2 cm dilatation to 102.1 at >6 cm dilatation. The number of neutrophils was significantly higher at 4-6 cm and >6 cm dilatation than at >2 cm, reaching maximum values at >6 cm dilatation, The findings in this study support the hypothesis that IL-8-induced infiltration of the cervical stroma by neutrophils and subsequent release of proteinases may play a key role in parturition.
Erscheinungsjahr
Zeitschriftentitel
HUMAN REPRODUCTION
Band
14
Zeitschriftennummer
4
Seite
1096-1100
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Winkler M, Fischer DC, Ruck P, et al. Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION. 1999;14(4):1096-1100.
Winkler, M., Fischer, D. C., Ruck, P., Marx, T., Kaiserling, E., Oberpichler, A., Tschesche, H., et al. (1999). Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION, 14(4), 1096-1100. doi:10.1093/humrep/14.4.1096
Winkler, M., Fischer, D. C., Ruck, P., Marx, T., Kaiserling, E., Oberpichler, A., Tschesche, H., and Rath, W. (1999). Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION 14, 1096-1100.
Winkler, M., et al., 1999. Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION, 14(4), p 1096-1100.
M. Winkler, et al., “Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment”, HUMAN REPRODUCTION, vol. 14, 1999, pp. 1096-1100.
Winkler, M., Fischer, D.C., Ruck, P., Marx, T., Kaiserling, E., Oberpichler, A., Tschesche, H., Rath, W.: Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment. HUMAN REPRODUCTION. 14, 1096-1100 (1999).
Winkler, M, Fischer, DC, Ruck, P, Marx, T, Kaiserling, E, Oberpichler, A, Tschesche, Harald, and Rath, W. “Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment”. HUMAN REPRODUCTION 14.4 (1999): 1096-1100.

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