Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome

Price B, Dennison C, Tschesche H, Elliott E (2000)
JOURNAL OF BIOLOGICAL CHEMISTRY 275(36): 28308-28315.

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Abstract
The human neutrophil granule location of precursors of matrix metalloproteinases (MMPs), MMP-8 and -9, has been established, but that of the tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) has not. In this study, labeling for TIMP-1, pro-MMP-8, pro-MMP-9, and established granule marker proteins reveals that TIMP-1 is mainly located in distinct oval, electron translucent organelles, a little larger than azurophil granules. A lack of labeling for the fluid phase endocytic marker, bovine serum albumin-gold, the lysosome-associated membrane protein markers, and for glycosylphosphatidylinositol-linked proteins, which are enriched in secretory vesicles, indicates the nonendosomal, non-lysosomal, and non-secretory nature of this organelle. Density gradient cofractionation with the least dense, secretory population and some pleomorphism of the organelle suggest it is a "vesicle" rather than a "granule" population. Colocalization with pro-MMP-9 or pro-MMP-8, in minor subpopulations, suggests that TIMP-1 vesicle biogenesis occurs between metamyelocytic and terminal differentiation and before secretory vesicle synthesis. Pulse-chased IgG-coated latex beads and immunolabeling show that specific and azurophil granules fuse with the phagosome whereas TIMP-1 and pro-MMP-9-containing organelles do not. This suggests that these play no role in phagosomal destruction of IgG-opsonized bacteria. Separate localization and colocalization of these proteins may, however, facilitate fine regulation of extracellular proteolysis.
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Price B, Dennison C, Tschesche H, Elliott E. Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome. JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(36):28308-28315.
Price, B., Dennison, C., Tschesche, H., & Elliott, E. (2000). Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(36), 28308-28315.
Price, B., Dennison, C., Tschesche, H., and Elliott, E. (2000). Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome. JOURNAL OF BIOLOGICAL CHEMISTRY 275, 28308-28315.
Price, B., et al., 2000. Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(36), p 28308-28315.
B. Price, et al., “Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome”, JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, 2000, pp. 28308-28315.
Price, B., Dennison, C., Tschesche, H., Elliott, E.: Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome. JOURNAL OF BIOLOGICAL CHEMISTRY. 275, 28308-28315 (2000).
Price, B, Dennison, C, Tschesche, Harald, and Elliott, E. “Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome”. JOURNAL OF BIOLOGICAL CHEMISTRY 275.36 (2000): 28308-28315.
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