Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system

Rathke-Hartlieb S, Budde P, Ewert S, Schlomann U, Staege MS, Jockusch H, Bartsch JW, Frey J (2000)
FEBS LETTERS 481(3): 227-234.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ;
Abstract
Reactive astrocytes occurring in response to neurodegeneration are thought to play an important role in neuronal regeneration by upregulating the expression of extracellular matrix (ECM) components as well as the ECM degrading metalloproteinases (MMPs). We examined the mRNA levels and cellular distribution of membrane type matrix metalloproteinase 1 (MT1-MMP) and tissue inhibitors 1-4 of MMPs (TIMPs) in brain stem and spinal cord of wobbler (WR) mutant mice affected by progressive neurodegeneration and astrogliosis. MT1-MMP, TIMP-1 and TIMP-3 mRNA levels were elevated, whereas TIMP-2 and TIMP-4 expression was not affected. MT1-MMP was expressed in reactive astrocytes of WR. In primary astrocyte cultures, MT1-MMP mRNA was upregulated by exogeneous tumor necrosis factor alpha. Increased plasma membrane and secreted MMP activities were found in primary WR astrocytes. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Publishing Year
ISSN
PUB-ID

Cite this

Rathke-Hartlieb S, Budde P, Ewert S, et al. Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS. 2000;481(3):227-234.
Rathke-Hartlieb, S., Budde, P., Ewert, S., Schlomann, U., Staege, M. S., Jockusch, H., Bartsch, J. W., et al. (2000). Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS, 481(3), 227-234.
Rathke-Hartlieb, S., Budde, P., Ewert, S., Schlomann, U., Staege, M. S., Jockusch, H., Bartsch, J. W., and Frey, J. (2000). Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS 481, 227-234.
Rathke-Hartlieb, S., et al., 2000. Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS, 481(3), p 227-234.
S. Rathke-Hartlieb, et al., “Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system”, FEBS LETTERS, vol. 481, 2000, pp. 227-234.
Rathke-Hartlieb, S., Budde, P., Ewert, S., Schlomann, U., Staege, M.S., Jockusch, H., Bartsch, J.W., Frey, J.: Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS. 481, 227-234 (2000).
Rathke-Hartlieb, S, Budde, P, Ewert, S, Schlomann, U, Staege, MS, Jockusch, Harald, Bartsch, JW, and Frey, Jürgen. “Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system”. FEBS LETTERS 481.3 (2000): 227-234.
This data publication is cited in the following publications:
This publication cites the following data publications:

14 Citations in Europe PMC

Data provided by Europe PubMed Central.

Extracellular environment contribution to astrogliosis-lessons learned from a tissue engineered 3D model of the glial scar.
Rocha DN, Ferraz-Nogueira JP, Barrias CC, Relvas JB, Pego AP., Front Cell Neurosci 9(), 2015
PMID: 26483632
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Langenfurth A, Rinnenthal JL, Vinnakota K, Prinz V, Carlo AS, Stadelmann C, Siffrin V, Peaschke S, Endres M, Heppner F, Glass R, Wolf SA, Kettenmann H., J. Neurosci. Res. 92(3), 2014
PMID: 24323769
Loss of vps54 function leads to vesicle traffic impairment, protein mis-sorting and embryonic lethality.
Karlsson P, Droce A, Moser JM, Cuhlmann S, Padilla CO, Heimann P, Bartsch JW, Fuchtbauer A, Fuchtbauer EM, Schmitt-John T., Int J Mol Sci 14(6), 2013
PMID: 23708095
The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism.
Hamdi Y, Kaddour H, Vaudry D, Bahdoudi S, Douiri S, Leprince J, Castel H, Vaudry H, Tonon MC, Amri M, Masmoudi-Kouki O., PLoS ONE 7(8), 2012
PMID: 22927932
Metalloproteinase alterations in the bone marrow of ALS patients.
Bossolasco P, Cova L, Calzarossa C, Servida F, Mencacci NE, Onida F, Polli E, Lambertenghi Deliliers G, Silani V., J. Mol. Med. 88(6), 2010
PMID: 20091292
ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice.
Mahoney ET, Benton RL, Maddie MA, Whittemore SR, Hagg T., J. Comp. Neurol. 512(2), 2009
PMID: 19003792
Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins.
Ogier C, Bernard A, Chollet AM, LE Diguardher T, Hanessian S, Charton G, Khrestchatisky M, Rivera S., Glia 54(4), 2006
PMID: 16845676
Astrocytes exert a pro-apoptotic effect on neurons in postnatal hippocampal cultures.
Shute AA, Cormier RJ, Moulder KL, Benz A, Isenberg KE, Zorumski CF, Mennerick S., Neuroscience 131(2), 2005
PMID: 15708478
The TIMPs tango with MMPs and more in the central nervous system.
Crocker SJ, Pagenstecher A, Campbell IL., J. Neurosci. Res. 75(1), 2004
PMID: 14689443
Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia.
Suryadevara R, Holter S, Borgmann K, Persidsky R, Labenz-Zink C, Persidsky Y, Gendelman HE, Wu L, Ghorpade A., Glia 44(1), 2003
PMID: 12951656

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 11007969
PubMed | Europe PMC

Search this title in

Google Scholar