Pregnancy-associated plasma protein-E (PAPP-E)

Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (2000)
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493(3): 356-362.

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A full-length cDNA encoding a novel human protein was cloned from placenta cDNA. The corresponding 1542 amino acid protein sequence was termed 'pregnancy-associated plasma protein-E' (PAPP-E) as it shows a 62% homology to the human pregnancy-associated plasma protein-A (PAPP-A) that is a diagnostic marker for trisomies, especially Down syndrome. The conserved domain structure contains five motifs related to the short consensus repeats of complement proteins and selectins, three motifs related to the lin-notch motifs of proteins regulating early tissue differentiation, and a putative zinc-binding motif and active site of the metzincin-superfamily of metalloproteases. The PAPP-E gene was localized to chromosome 1q23-25. Northern blot analysis showed that PAPP-E is predominantly expressed in placenta. (C) 2000 Elsevier Science B.V. All rights reserved.
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Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H. Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 2000;1493(3):356-362.
Farr, M., Strube, J., Geppert, H. G., Kocourek, A., Mahne, M., & Tschesche, H. (2000). Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1493(3), 356-362. doi:10.1016/S0167-4781(00)00195-0
Farr, M., Strube, J., Geppert, H. G., Kocourek, A., Mahne, M., and Tschesche, H. (2000). Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493, 356-362.
Farr, M., et al., 2000. Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1493(3), p 356-362.
M. Farr, et al., “Pregnancy-associated plasma protein-E (PAPP-E)”, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, vol. 1493, 2000, pp. 356-362.
Farr, M., Strube, J., Geppert, H.G., Kocourek, A., Mahne, M., Tschesche, H.: Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 1493, 356-362 (2000).
Farr, M, Strube, J, Geppert, HG, Kocourek, A, Mahne, M, and Tschesche, Harald. “Pregnancy-associated plasma protein-E (PAPP-E)”. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493.3 (2000): 356-362.
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PAPP-A levels of late pregnancy in preeclampsia and HELLP syndrome.
Atis A, Aydin Y, Basol E, Kaleli S, Turgay F, Goker N., Arch Gynecol Obstet 285(1), 2012
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Altered placental expression of PAPPA2 does not affect birth weight in mice.
Wagner PK, Christians JK., Reprod Biol Endocrinol 8(), 2010
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Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.
Nishizawa H, Pryor-Koishi K, Suzuki M, Kato T, Kogo H, Sekiya T, Kurahashi H, Udagawa Y., Mol Hum Reprod 14(10), 2008
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Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex.
García-Castellanos R, Tallant C, Marrero A, Solà M, Baumann U, Gomis-Rüth FX., Arch Biochem Biophys 457(1), 2007
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Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease.
Tallant C, García-Castellanos R, Marrero A, Canals F, Yang Y, Reymond JL, Solà M, Baumann U, Gomis-Rüth FX., Biol Chem 388(11), 2007
PMID: 17976018
Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.
Boldt HB, Overgaard MT, Laursen LS, Weyer K, Sottrup-Jensen L, Oxvig C., Biochem J 358(pt 2), 2001
PMID: 11513734

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