Pregnancy-associated plasma protein-E (PAPP-E)

Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (2000)
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493(3): 356-362.

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Abstract
A full-length cDNA encoding a novel human protein was cloned from placenta cDNA. The corresponding 1542 amino acid protein sequence was termed 'pregnancy-associated plasma protein-E' (PAPP-E) as it shows a 62% homology to the human pregnancy-associated plasma protein-A (PAPP-A) that is a diagnostic marker for trisomies, especially Down syndrome. The conserved domain structure contains five motifs related to the short consensus repeats of complement proteins and selectins, three motifs related to the lin-notch motifs of proteins regulating early tissue differentiation, and a putative zinc-binding motif and active site of the metzincin-superfamily of metalloproteases. The PAPP-E gene was localized to chromosome 1q23-25. Northern blot analysis showed that PAPP-E is predominantly expressed in placenta. (C) 2000 Elsevier Science B.V. All rights reserved.
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Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H. Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 2000;1493(3):356-362.
Farr, M., Strube, J., Geppert, H. G., Kocourek, A., Mahne, M., & Tschesche, H. (2000). Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1493(3), 356-362.
Farr, M., Strube, J., Geppert, H. G., Kocourek, A., Mahne, M., and Tschesche, H. (2000). Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493, 356-362.
Farr, M., et al., 2000. Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1493(3), p 356-362.
M. Farr, et al., “Pregnancy-associated plasma protein-E (PAPP-E)”, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, vol. 1493, 2000, pp. 356-362.
Farr, M., Strube, J., Geppert, H.G., Kocourek, A., Mahne, M., Tschesche, H.: Pregnancy-associated plasma protein-E (PAPP-E). BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 1493, 356-362 (2000).
Farr, M, Strube, J, Geppert, HG, Kocourek, A, Mahne, M, and Tschesche, Harald. “Pregnancy-associated plasma protein-E (PAPP-E)”. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1493.3 (2000): 356-362.
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Kloverpris S, Gaidamauskas E, Rasmussen LC, Overgaard MT, Kronborg C, Knudsen UB, Christiansen M, Kumar A, Oxvig C., Mol. Hum. Reprod. 19(11), 2013
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Atis A, Aydin Y, Basol E, Kaleli S, Turgay F, Goker N., Arch. Gynecol. Obstet. 285(1), 2012
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Altered placental expression of PAPPA2 does not affect birth weight in mice.
Wagner PK, Christians JK., Reprod. Biol. Endocrinol. 8(), 2010
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Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease.
Tallant C, Garcia-Castellanos R, Marrero A, Canals F, Yang Y, Reymond JL, Sola M, Baumann U, Gomis-Ruth FX., Biol. Chem. 388(11), 2007
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Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex.
Garcia-Castellanos R, Tallant C, Marrero A, Sola M, Baumann U, Gomis-Ruth FX., Arch. Biochem. Biophys. 457(1), 2007
PMID: 17097044

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