Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice

Wieneke S, Stehle R, Li ZL, Jockusch H (2000)
Biochemical and biophysical research communications 278(2): 419-425.

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Abstract
We have investigated the physiological role of desmin in skeletal muscle by measuring isometric tension generated in skinned fibres and intact skeletal muscles from desmin knock-out (DES-KO) mice. About 80% of skinned single extensor digitorum longus (EDL) fibres from adult DES-KO mice generated tensions close to that of wild-type (WT) controls. Weights and maximum tensions of intact EDL but not of soleus (SOL) muscles were lowered in DES-KO mice. Repeated contractions with stretch did not affect subsequent isometric tension in EDL muscles of DES-KO mice. Tension during high frequency fatigue (HFF) declined faster and this deficiency was compensated in DES-KO EDL muscles by 5 mM caffeine which had no influence on HFF in WT EDL. Furthermore, caffeine evoked twitch potentiation was higher in DES-KO than in WT muscles. We conclude that desmin is not essential for acute tensile strength but rather for optimal activation of intact myofibres during E-C coupling. (C) 2000 Academic Press.
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Wieneke S, Stehle R, Li ZL, Jockusch H. Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice. Biochemical and biophysical research communications. 2000;278(2):419-425.
Wieneke, S., Stehle, R., Li, Z. L., & Jockusch, H. (2000). Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice. Biochemical and biophysical research communications, 278(2), 419-425.
Wieneke, S., Stehle, R., Li, Z. L., and Jockusch, H. (2000). Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice. Biochemical and biophysical research communications 278, 419-425.
Wieneke, S., et al., 2000. Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice. Biochemical and biophysical research communications, 278(2), p 419-425.
S. Wieneke, et al., “Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice”, Biochemical and biophysical research communications, vol. 278, 2000, pp. 419-425.
Wieneke, S., Stehle, R., Li, Z.L., Jockusch, H.: Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice. Biochemical and biophysical research communications. 278, 419-425 (2000).
Wieneke, S, Stehle, R, Li, ZL, and Jockusch, Harald. “Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice”. Biochemical and biophysical research communications 278.2 (2000): 419-425.
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