Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus)

Bläsing B, Nossoll M, Teuchert-Noodt G, Dawirs RR (2001)
JOURNAL OF NEURAL TRANSMISSION 108(1): 101-113.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The effect of a single methamphetamine application on postnatal maturation of the prefrontal cortex was studied using pyramidal cell morphology and spine density as parameters of systemic plasticity. Male gerbils were injected a single dose of methamphetamine (METH, 50 mg/kg, i.p.) on postnatal day 14. On postnatal day 90, prefrontal cortices of METH-treated animals and saline-treated controls were processed for Golgi-staining. Dendritic arbours of layer III and V pyramidal neurones were measured to describe pyramidal cell morphology, and segmental spine counts were carried out. The results showed that a single postnatal METH-challenge significantly alters morphological differentiation of pyramidal cells towards adulthood. Cells from METH-treated animals showed a higher total dendritic length based on longer segments between subsequent dendritic branchings, with only the apical stem dendrite being shorter in METH-treated than in control subjects. The branching rate was slightly but not significantly increased in METH-treated animals. Nevertheless, spine density was significantly increased on all types of dendrites, with apical dendrites of both layers III and V showing the highest drug-induced progression of about 50% compared to control values. The present results are discussed with regard to probable clues they may provide for investigating neurobiological principles of psychotic behaviour in an animal model.
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Zeitschriftentitel
JOURNAL OF NEURAL TRANSMISSION
Band
108
Zeitschriftennummer
1
Seite
101-113
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Bläsing B, Nossoll M, Teuchert-Noodt G, Dawirs RR. Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION. 2001;108(1):101-113.
Bläsing, B., Nossoll, M., Teuchert-Noodt, G., & Dawirs, R. R. (2001). Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION, 108(1), 101-113. doi:10.1007/s007020170101
Bläsing, B., Nossoll, M., Teuchert-Noodt, G., and Dawirs, R. R. (2001). Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION 108, 101-113.
Bläsing, B., et al., 2001. Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION, 108(1), p 101-113.
B. Bläsing, et al., “Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus)”, JOURNAL OF NEURAL TRANSMISSION, vol. 108, 2001, pp. 101-113.
Bläsing, B., Nossoll, M., Teuchert-Noodt, G., Dawirs, R.R.: Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION. 108, 101-113 (2001).
Bläsing, Bettina, Nossoll, M, Teuchert-Noodt, Gertraud, and Dawirs, RR. “Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus)”. JOURNAL OF NEURAL TRANSMISSION 108.1 (2001): 101-113.

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