Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus)

Bläsing B, Nossoll M, Teuchert-Noodt G, Dawirs RR (2001)
JOURNAL OF NEURAL TRANSMISSION 108(1): 101-113.

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The effect of a single methamphetamine application on postnatal maturation of the prefrontal cortex was studied using pyramidal cell morphology and spine density as parameters of systemic plasticity. Male gerbils were injected a single dose of methamphetamine (METH, 50 mg/kg, i.p.) on postnatal day 14. On postnatal day 90, prefrontal cortices of METH-treated animals and saline-treated controls were processed for Golgi-staining. Dendritic arbours of layer III and V pyramidal neurones were measured to describe pyramidal cell morphology, and segmental spine counts were carried out. The results showed that a single postnatal METH-challenge significantly alters morphological differentiation of pyramidal cells towards adulthood. Cells from METH-treated animals showed a higher total dendritic length based on longer segments between subsequent dendritic branchings, with only the apical stem dendrite being shorter in METH-treated than in control subjects. The branching rate was slightly but not significantly increased in METH-treated animals. Nevertheless, spine density was significantly increased on all types of dendrites, with apical dendrites of both layers III and V showing the highest drug-induced progression of about 50% compared to control values. The present results are discussed with regard to probable clues they may provide for investigating neurobiological principles of psychotic behaviour in an animal model.
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Bläsing B, Nossoll M, Teuchert-Noodt G, Dawirs RR. Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION. 2001;108(1):101-113.
Bläsing, B., Nossoll, M., Teuchert-Noodt, G., & Dawirs, R. R. (2001). Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION, 108(1), 101-113.
Bläsing, B., Nossoll, M., Teuchert-Noodt, G., and Dawirs, R. R. (2001). Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION 108, 101-113.
Bläsing, B., et al., 2001. Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION, 108(1), p 101-113.
B. Bläsing, et al., “Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus)”, JOURNAL OF NEURAL TRANSMISSION, vol. 108, 2001, pp. 101-113.
Bläsing, B., Nossoll, M., Teuchert-Noodt, G., Dawirs, R.R.: Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus). JOURNAL OF NEURAL TRANSMISSION. 108, 101-113 (2001).
Bläsing, Bettina, Nossoll, M, Teuchert-Noodt, Gertraud, and Dawirs, RR. “Postnatal maturation of prefrontal pyramidal neurones is sensitive to a single early dose of methamphetamine in gerbils (Meriones unguiculatus)”. JOURNAL OF NEURAL TRANSMISSION 108.1 (2001): 101-113.
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Kolb B, Gibb R., Front Cell Neurosci 9(), 2015
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Altered neurometabolites and motor integration in children exposed to methamphetamine in utero.
Chang L, Cloak C, Jiang CS, Farnham S, Tokeshi B, Buchthal S, Hedemark B, Smith LM, Ernst T., Neuroimage 48(2), 2009
PMID: 19576287
Lower diffusion in white matter of children with prenatal methamphetamine exposure.
Cloak CC, Ernst T, Fujii L, Hedemark B, Chang L., Neurology 72(24), 2009
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Activity-dependent structural plasticity.
Butz M, Worgotter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072
Inverse relationship between adult hippocampal cell proliferation and synaptic rewiring in the dentate gyrus.
Butz M, Teuchert-Noodt G, Grafen K, van Ooyen A., Hippocampus 18(9), 2008
PMID: 18481284
Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis.
Brummelte S, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 114(5), 2007
PMID: 17195918
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
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NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine.
Golub M, Costa L, Crofton K, Frank D, Fried P, Gladen B, Henderson R, Liebelt E, Lusskin S, Marty S, Rowland A, Scialli J, Vore M., Birth Defects Res. B Dev. Reprod. Toxicol. 74(6), 2005
PMID: 16167346
Postnatal maturation of cortical serotonin lateral asymmetry in gerbils is vulnerable to both environmental and pharmacological epigenetic challenges.
Neddens J, Dawirs RR, Bagorda F, Busche A, Horstmann S, Teuchert-Noodt G., Brain Res. 1021(2), 2004
PMID: 15342268
The anatomy of the cerebral cortex of the echidna (Tachyglossus aculeatus).
Hassiotis M, Paxinos G, Ashwell KW., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 136(4), 2003
PMID: 14667848

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