Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses

Ragg H, Lokot T, Kamp P-B, Atchley WR, Dress A (2001)
MOLECULAR BIOLOGY AND EVOLUTION 18(4): 577-584.

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Abstract
A combination of three independent biological features, genomic organization, diagnostic amino acid sites, and rare indels, was used to elucidate the phylogeny of the vertebrate serpin (serine protease inhibitor) superfamily. A strong correlation between serpin gene families displaying (1) a conserved exon-intron pattern and (2) family-specific combinations of amino acid residues at specific sites suggests that present-day vertebrates encompass six serpin gene families which evolved from primordial genes by massive intron insertion before or during early vertebrate radiation. Introns placed at homologous positions in the gene sequences in combination with diagnostic sequence characters may also constitute a reliable kinship indicator for other protein superfamilies.
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Ragg H, Lokot T, Kamp P-B, Atchley WR, Dress A. Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION. 2001;18(4):577-584.
Ragg, H., Lokot, T., Kamp, P. - B., Atchley, W. R., & Dress, A. (2001). Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION, 18(4), 577-584.
Ragg, H., Lokot, T., Kamp, P. - B., Atchley, W. R., and Dress, A. (2001). Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION 18, 577-584.
Ragg, H., et al., 2001. Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION, 18(4), p 577-584.
H. Ragg, et al., “Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses”, MOLECULAR BIOLOGY AND EVOLUTION, vol. 18, 2001, pp. 577-584.
Ragg, H., Lokot, T., Kamp, P.-B., Atchley, W.R., Dress, A.: Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION. 18, 577-584 (2001).
Ragg, Hermann, Lokot, Tatjana, Kamp, Paul-Bertram, Atchley, William R., and Dress, Andreas. “Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses”. MOLECULAR BIOLOGY AND EVOLUTION 18.4 (2001): 577-584.
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26 Citations in Europe PMC

Data provided by Europe PubMed Central.

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PMID: 24840053

23 References

Data provided by Europe PubMed Central.

Complete nucleotide sequence of the gene for human C1 inhibitor with an unusually high density of Alu elements.
Carter PE, Duponchel C, Tosi M, Fothergill JE., Eur. J. Biochem. 197(2), 1991
PMID: 2026152
Isolation of frog and chicken cDNAs encoding heparin cofactor II.
Colwell NS, Tollefsen DM., Thromb. Haemost. 80(5), 1998
PMID: 9843172
Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.
Hayashi Y, Mori Y, Janssen OE, Sunthornthepvarakul T, Weiss RE, Takeda K, Weinberg M, Seo H, Bell GI, Refetoff S., Mol. Endocrinol. 7(8), 1993
PMID: 8232304

AUTHOR UNKNOWN, Nucleic Acids Res. 10(), 1982
Organization of serpin gene-1 from Manduca sexta. Evolution of a family of alternate exons encoding the reactive site loop.
Jiang H, Wang Y, Huang Y, Mulnix AB, Kadel J, Cole K, Kanost MR., J. Biol. Chem. 271(45), 1996
PMID: 8910411
Evolutionary relationships among the serpins.
Marshall CJ., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 342(1300), 1993
PMID: 7904353
Renin-angiotensin system in primitive bony fishes and a holocephalian.
Nishimura H, Ogawa M, Sawyer WH., Am. J. Physiol. 224(4), 1973
PMID: 4349179
The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
Potempa J, Korzus E, Travis J., J. Biol. Chem. 269(23), 1994
PMID: 8206889
Structure and expression of the gene coding for the human serpin hLS2.
Ragg H, Preibisch G., J. Biol. Chem. 263(24), 1988
PMID: 2841345
The ovalbumin family of serpin proteins.
Remold-O'Donnell E., FEBS Lett. 315(2), 1993
PMID: 8417965
RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.
Soares MB, Schon E, Henderson A, Karathanasis SK, Cate R, Zeitlin S, Chirgwin J, Efstratiadis A., Mol. Cell. Biol. 5(8), 1985
PMID: 2427930
Comparative studies of the juxtaglomerular apparatus.
Sokabe H, Ogawa M., Int. Rev. Cytol. 37(0), 1974
PMID: 4365425
Parsimony, likelihood, and the role of models in molecular phylogenetics.
Steel M, Penny D., Mol. Biol. Evol. 17(6), 2000
PMID: 10833190
An mRNA-type intron is present in the Rhodotorula hasegawae U2 small nuclear RNA gene.
Takahashi Y, Urushiyama S, Tani T, Ohshima Y., Mol. Cell. Biol. 13(9), 1993
PMID: 8355704
Common structural organization of the angiotensinogen and the alpha 1-antitrypsin genes.
Tanaka T, Ohkubo H, Nakanishi S., J. Biol. Chem. 259(13), 1984
PMID: 6330095

AUTHOR UNKNOWN, JOURNAL OF MOLECULAR EVOLUTION 36(), 1993

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