The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases

Tschesche H, Zolzer V, Triebel S, Bartsch S (2001)

No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

; ; ;
The human neutrophil lipocalin (HNL), a member of the large family of lipocalins that exhibit various physiological functions, is coexpressed in granulocytes with progelatinase B (MMP-9). Part of it is covalently bound to the proenzyme and therefore may play a possible role in the activation process: of promatrix metalloproteinases. We now report that HNL is able to accelerate the direct activation of promatrix metalloproteinases slightly. A significant enhancement of the activity could be demonstrated for the HgCl2- and the plasma kallikrein-induced activation of all three secretory forms of proMMP-9 and of proMMP-8. The same activating effects were exerted by HNL isolated from granulocytes as well as by the recombinant forms expressed by the yeast Pichia pastoris or by Escherichia coli. This demonstrates that the carbohydrate moiety is not essential for the biological activity of HNL. Activation and activity enhancement are obviously mediated by entrapping the remaining N-terminal sequence residues of the partially truncated proenzyme into the hydrophobic binding pocket of the HNL. In conclusion these results document that HNL can exert an enzyme-activating effect in the regulation of inflammatory and pathophysiological responses of granulocytes in the physiological activation of MMPs that have been subject to limited proteolytic processing.
Publishing Year

Cite this

Tschesche H, Zolzer V, Triebel S, Bartsch S. The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases. EUROPEAN JOURNAL OF BIOCHEMISTRY. 2001;268(7):1918-1928.
Tschesche, H., Zolzer, V., Triebel, S., & Bartsch, S. (2001). The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases. EUROPEAN JOURNAL OF BIOCHEMISTRY, 268(7), 1918-1928. doi:10.1046/j.1432-1327.2001.02066.x
Tschesche, H., Zolzer, V., Triebel, S., and Bartsch, S. (2001). The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases. EUROPEAN JOURNAL OF BIOCHEMISTRY 268, 1918-1928.
Tschesche, H., et al., 2001. The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases. EUROPEAN JOURNAL OF BIOCHEMISTRY, 268(7), p 1918-1928.
H. Tschesche, et al., “The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases”, EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 268, 2001, pp. 1918-1928.
Tschesche, H., Zolzer, V., Triebel, S., Bartsch, S.: The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases. EUROPEAN JOURNAL OF BIOCHEMISTRY. 268, 1918-1928 (2001).
Tschesche, Harald, Zolzer, V, Triebel, S, and Bartsch, S. “The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases”. EUROPEAN JOURNAL OF BIOCHEMISTRY 268.7 (2001): 1918-1928.
This data publication is cited in the following publications:
This publication cites the following data publications:

45 Citations in Europe PMC

Data provided by Europe PubMed Central.

Thyroid hormone-mediated regulation of lipocalin 2 through the Met/FAK pathway in liver cancer.
Chung IH, Chen CY, Lin YH, Chi HC, Huang YH, Tai PJ, Liao CJ, Tsai CY, Lin SL, Wu MH, Chen CY, Lin KH., Oncotarget 6(17), 2015
PMID: 25940797
Diverse functional roles of lipocalin-2 in the central nervous system.
Jha MK, Lee S, Park DH, Kook H, Park KG, Lee IK, Suk K., Neurosci Biobehav Rev 49(), 2015
PMID: 25511817
Neutrophil gelatinase B-associated lipocalin and matrix metalloproteinase-9 complex as a surrogate serum marker of mucosal healing in ulcerative colitis.
de Bruyn M, Arijs I, Wollants WJ, Machiels K, Van Steen K, Van Assche G, Ferrante M, Rutgeerts P, Vermeire S, Opdenakker G., Inflamm. Bowel Dis. 20(7), 2014
PMID: 24871805
Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues.
Nam Y, Kim JH, Seo M, Kim JH, Jin M, Jeon S, Seo JW, Lee WH, Bing SJ, Jee Y, Lee WK, Park DH, Kook H, Suk K., J. Biol. Chem. 289(24), 2014
PMID: 24808182
Adipokines as potential biomarkers in rheumatoid arthritis.
Del Prete A, Salvi V, Sozzani S., Mediators Inflamm. 2014(), 2014
PMID: 24799765
Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancer.
Ding L, Zhao Y, Warren CL, Sullivan R, Eliceiri KW, Shull JD., BMC Cancer 13(), 2013
PMID: 24304664
Lipocalin-2 elicited by advanced glycation end-products promotes the migration of vascular smooth muscle cells.
Chung TW, Choi HJ, Kim CH, Jeong HS, Ha KT., Biochim. Biophys. Acta 1833(12), 2013
PMID: 24149112
Expression and complex formation of MMP9, MMP2, NGAL, and TIMP1 in porcine myocardium but not in skeletal muscles in male pigs with tachycardia-induced systolic heart failure.
Kiczak L, Tomaszek A, Bania J, Paslawska U, Zacharski M, Noszczyk-Nowak A, Janiszewski A, Skrzypczak P, Ardehali H, Jankowska EA, Ponikowski P., Biomed Res Int 2013(), 2013
PMID: 23710440
No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer.
Cramer EP, Glenthoj A, Hager M, Juncker-Jensen A, Engelholm LH, Santoni-Rugiu E, Lund LR, Laerum OD, Cowland JB, Borregaard N., PLoS ONE 7(6), 2012
PMID: 22737251
Nitroglycerin alters matrix remodeling proteins in THP-1 human macrophages and plasma metalloproteinase activity in rats.
Krishnatry AS, Fung SM, Brazeau DA, Soda D, Fung HL., Nitric Oxide 24(2), 2011
PMID: 21156214
Co-expression by keratinocytes of migration stimulating factor (MSF) and a functional inhibitor of its bioactivity (MSFI).
Jones SJ, Florence MM, Ellis IR, Kankova K, Schor SL, Schor AM., Exp. Cell Res. 313(20), 2007
PMID: 17949711
Biochemical and enzymatic characterization of purified covalent complexes of matrix metalloproteinase-9 and haptoglobin released by bovine granulocytes in vitro.
Bannikov GA, Mattoon JS, Abrahamsen EJ, Premanandan C, Green-Church KB, Marsh AE, Lakritz J., Am. J. Vet. Res. 68(9), 2007
PMID: 17764415
Construction of mathematical model for high-level expression of foreign genes in pPIC9 vector and its verification.
Wu B, Cha L, Du Z, Ying X, Li H, Xu L, Zheng X, Li E, Li W., Biochem. Biophys. Res. Commun. 354(2), 2007
PMID: 17239823
Induction of matrix metalloproteinase-9 in mice during Toxocara canis larvae migration.
Lai SC, Chen KM, Chen HC, Lee HH., Parasitol. Res. 95(3), 2005
PMID: 15645290

44 References

Data provided by Europe PubMed Central.

Latent collagenase and gelatinase from human neutrophils and their activation.
Tschesche H, Knauper V, Kramer S, Michaelis J, Oberhoff R, Reinke H., Matrix Suppl 1(), 1992
PMID: 1480034
A sandwich enzyme immunoassay for the determination of neutrophil lipocalin in body fluids.
Blaser J, Triebel S, Tschesche H., Clin. Chim. Acta 235(2), 1995
PMID: 7554268
Synthetic substrates for vertebrate collagenase.
Masui Y, Takemoto T, Sakakibara S, Hori H, Nagai Y., Biochem Med 17(2), 1977
PMID: 193489
The reliability of molecular weight determination by sulfate-polyacrylamide gel electrophoresis
Weber, J. Biol. Chem. 244(), 1968
Mercurial activation of human PMN leucocyte type IV procollagenase (gelatinase).
Triebel S, Blaser J, Reinke H, Knauper V, Tschesche H., FEBS Lett. 298(2-3), 1992
PMID: 1312026
Mercurial activation of human polymorphonuclear leucocyte procollagenase.
Blaser J, Knauper V, Osthues A, Reinke H, Tschesche H., Eur. J. Biochem. 202(3), 1991
PMID: 1662606
Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils.
Bundgaard JR, Sengelov H, Borregaard N, Kjeldsen L., Biochem. Biophys. Res. Commun. 202(3), 1994
PMID: 8060329
Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins.
Nagata A, Suzuki Y, Igarashi M, Eguchi N, Toh H, Urade Y, Hayaishi O., Proc. Natl. Acad. Sci. U.S.A. 88(9), 1991
PMID: 1902577
Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins.
Toh H, Kubodera H, Nakajima N, Sekiya T, Eguchi N, Tanaka T, Urade Y, Hayaishi O., Protein Eng. 9(12), 1996
PMID: 9010921
Xanthophyll cycle enzymes are members of the lipocalin family, the first identified from plants.
Bugos RC, Hieber AD, Yamamoto HY., J. Biol. Chem. 273(25), 1998
PMID: 9624110
Proteolytic and non-proteolytic activation of human neutrophil progelatinase B.
Sang QX, Birkedal-Hansen H, Van Wart HE., Biochim. Biophys. Acta 1251(2), 1995
PMID: 7669817
The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin
Coles, J. Mol. Biol. 289(), 1999
Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin.
Goetz DH, Willie ST, Armen RS, Bratt T, Borregaard N, Strong RK., Biochemistry 39(8), 2000
PMID: 10684642


0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®


PMID: 11277914
PubMed | Europe PMC

Search this title in

Google Scholar