First synthesis of beta(2)-homoamino acid by enantioselective catalysis

Rimkus A, Sewald N (2003)
ORGANIC LETTERS 5(1): 79-80.

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Abstract
The enantioselective conjugate addition of diethylzinc to the activated nitroolefin methyl 3-nitropropenoate is efficiently catalyzed by copper(I) complexes with BINOL-based enantiopure phosphoramidite ligands. The nitroolefin moiety acts as the predominant Michael acceptor, giving rise to the unambiguous formation of 2-alkyl-3-nitro-propanoates. Moderate to excellent enantioselectivities and high chemical yields are obtained. The product can easily be transformed into a beta(2)-homoamino acid.
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Rimkus A, Sewald N. First synthesis of beta(2)-homoamino acid by enantioselective catalysis. ORGANIC LETTERS. 2003;5(1):79-80.
Rimkus, A., & Sewald, N. (2003). First synthesis of beta(2)-homoamino acid by enantioselective catalysis. ORGANIC LETTERS, 5(1), 79-80.
Rimkus, A., and Sewald, N. (2003). First synthesis of beta(2)-homoamino acid by enantioselective catalysis. ORGANIC LETTERS 5, 79-80.
Rimkus, A., & Sewald, N., 2003. First synthesis of beta(2)-homoamino acid by enantioselective catalysis. ORGANIC LETTERS, 5(1), p 79-80.
A. Rimkus and N. Sewald, “First synthesis of beta(2)-homoamino acid by enantioselective catalysis”, ORGANIC LETTERS, vol. 5, 2003, pp. 79-80.
Rimkus, A., Sewald, N.: First synthesis of beta(2)-homoamino acid by enantioselective catalysis. ORGANIC LETTERS. 5, 79-80 (2003).
Rimkus, A, and Sewald, Norbert. “First synthesis of beta(2)-homoamino acid by enantioselective catalysis”. ORGANIC LETTERS 5.1 (2003): 79-80.
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