An interferon-gamma-binding protein of novel structure encoded by the fowlpox virus

Puehler F, Schwarz H, Waidner B, Kalinowski J, Kaspers B, Bereswill S, Staeheli P (2003)
JOURNAL OF BIOLOGICAL CHEMISTRY 278(9): 6905-6911.

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Abstract
Poxviruses have evolved various strategies to counteract the host immune response, one of which is based on the expression of soluble cytokine receptors. Using various biological assays, we detected a chicken interferon-gamma (chIFN-gamma)-neutralizing activity in supernatants of fowlpox virus (FPV)-infected cells that could be destroyed by trypsin treatment. Secreted viral proteins were purified by affinity chromatography using matrix-immobilized chIFN-gamma, followed by two-dimensional gel electrophoresis. Matrix-assisted laser desorption/ionization time of Right mass spectrometry (MALDI-TOF MS) analysis indicated that the viral IFN-gamma-binding protein in question was encoded by the FPV gene 016. The chicken IFN-gamma binding and neutralizing activity of the recombinant FPV016 protein was confirmed using supernatants of cells infected with a recombinant vaccinia virus that lacked its own IFN-gamma-binding protein but instead expressed the FPV016 gene. The FPV016 gene product also neutralized the activity of duck and human IFN-gamma but failed to neutralize the activity of mouse and rat IFN-gamma. Unlike previously known cellular and poxviral IFN-y receptors, which all contain fibronectin type III domains, the IFN-gamma-binding protein of FPV contains an immunoglobulin domain. Remarkably, it exhibits no significant homology to any known viral or cellular protein. Because IFN-gamma receptors of birds have not yet been characterized at the molecular level, the possibility remains that FPV016 represents a hijacked chicken gene and that avian and mammalian IFN-gamma receptors have fundamentally different primary structures.
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Puehler F, Schwarz H, Waidner B, et al. An interferon-gamma-binding protein of novel structure encoded by the fowlpox virus. JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):6905-6911.
Puehler, F., Schwarz, H., Waidner, B., Kalinowski, J., Kaspers, B., Bereswill, S., & Staeheli, P. (2003). An interferon-gamma-binding protein of novel structure encoded by the fowlpox virus. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(9), 6905-6911.
Puehler, F., Schwarz, H., Waidner, B., Kalinowski, J., Kaspers, B., Bereswill, S., and Staeheli, P. (2003). An interferon-gamma-binding protein of novel structure encoded by the fowlpox virus. JOURNAL OF BIOLOGICAL CHEMISTRY 278, 6905-6911.
Puehler, F., et al., 2003. An interferon-gamma-binding protein of novel structure encoded by the fowlpox virus. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(9), p 6905-6911.
F. Puehler, et al., “An interferon-gamma-binding protein of novel structure encoded by the fowlpox virus”, JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, 2003, pp. 6905-6911.
Puehler, F., Schwarz, H., Waidner, B., Kalinowski, J., Kaspers, B., Bereswill, S., Staeheli, P.: An interferon-gamma-binding protein of novel structure encoded by the fowlpox virus. JOURNAL OF BIOLOGICAL CHEMISTRY. 278, 6905-6911 (2003).
Puehler, F, Schwarz, H, Waidner, B, Kalinowski, Jörn, Kaspers, B, Bereswill, S, and Staeheli, P. “An interferon-gamma-binding protein of novel structure encoded by the fowlpox virus”. JOURNAL OF BIOLOGICAL CHEMISTRY 278.9 (2003): 6905-6911.
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