Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality

Strobel A, Spinath FM, Angleitner A, Riemann R, Lesch KP (2003)
NEUROPSYCHOBIOLOGY 47(1): 52-56.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ;
Abstract
Recent studies have suggested a role of two polymorphisms of the dopamine D-4 receptor gene (DRD4 exon III and -521C/T) in the modulation of personality traits such as 'novelty seeking' or 'extraversion', which are supposed to be modulated by individual differences in dopaminergic function. However, several replication studies have not provided positive findings. The present study was performed to further investigate whether DRD4 exon III and -521C/T are associated with individual differences in personality. One hundred and fifteen healthy German volunteers completed the NEO-Five-Factor Inventory (NEO-FFI) and were genotyped for the two DRD4 polymorphisms. We found no association between DRD4 exon III and -521C/T, respectively, and estimated novelty seeking, NEO-FFI extraversion or other personality factors. Our findings are in line with several earlier studies which have failed to replicate the initial association results. Hence, our data do not provide evidence for a role of DRD4 exon III and the -521C/T polymorphism in the modulation of novelty seeking and extraversion. Copyright (C) 2003 S. Karger AG, Basel.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Strobel A, Spinath FM, Angleitner A, Riemann R, Lesch KP. Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality. NEUROPSYCHOBIOLOGY. 2003;47(1):52-56.
Strobel, A., Spinath, F. M., Angleitner, A., Riemann, R., & Lesch, K. P. (2003). Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality. NEUROPSYCHOBIOLOGY, 47(1), 52-56.
Strobel, A., Spinath, F. M., Angleitner, A., Riemann, R., and Lesch, K. P. (2003). Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality. NEUROPSYCHOBIOLOGY 47, 52-56.
Strobel, A., et al., 2003. Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality. NEUROPSYCHOBIOLOGY, 47(1), p 52-56.
A. Strobel, et al., “Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality”, NEUROPSYCHOBIOLOGY, vol. 47, 2003, pp. 52-56.
Strobel, A., Spinath, F.M., Angleitner, A., Riemann, R., Lesch, K.P.: Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality. NEUROPSYCHOBIOLOGY. 47, 52-56 (2003).
Strobel, A, Spinath, FM, Angleitner, Alois, Riemann, Rainer, and Lesch, KP. “Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality”. NEUROPSYCHOBIOLOGY 47.1 (2003): 52-56.
This data publication is cited in the following publications:
This publication cites the following data publications:

12 Citations in Europe PMC

Data provided by Europe PubMed Central.

Impulsive and compulsive behaviors in Parkinson's disease.
Zhang G, Zhang Z, Liu L, Yang J, Huang J, Xiong N, Wang T., Front Aging Neurosci 6(), 2014
PMID: 25452726
DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.
Das D, Cherbuin N, Tan X, Anstey KJ, Easteal S., PLoS ONE 6(5), 2011
PMID: 21637770
The association of DRD4 and novelty seeking is found in a nonhuman primate model.
Bailey JN, Breidenthal SE, Jorgensen MJ, McCracken JT, Fairbanks LA., Psychiatr. Genet. 17(1), 2007
PMID: 17167341
Genetic structure of the dopamine receptor D4 gene (DRD4) and lack of association with schizophrenia in Japanese patients.
Mitsuyasu H, Kawasaki H, Ninomiya H, Kinukawa N, Yamanaka T, Tahira T, Stanton VP Jr, Springett GM, Hayashi K, Tashiro N, Kanba S., J Psychiatr Res 41(9), 2007
PMID: 16887146
Dopamine and cognitive control: the influence of spontaneous eyeblink rate and dopamine gene polymorphisms on perseveration and distractibility.
Dreisbach G, Muller J, Goschke T, Strobel A, Schulze K, Lesch KP, Brocke B., Behav. Neurosci. 119(2), 2005
PMID: 15839794
Genetic variants implicated in personality: a review of the more promising candidates.
Savitz JB, Ramesar RS., Am. J. Med. Genet. B Neuropsychiatr. Genet. 131B(1), 2004
PMID: 15389772
A polymorphism of the beta1-adrenergic receptor is associated with low extraversion.
Stein MB, Schork NJ, Gelernter J., Biol. Psychiatry 56(4), 2004
PMID: 15312808
Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers.
Jonsson EG, Bah J, Melke J, Abou Jamra R, Schumacher J, Westberg L, Ivo R, Cichon S, Propping P, Nothen MM, Eriksson E, Sedvall GC., BMC Psychiatry 4(), 2004
PMID: 15102340

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 12606846
PubMed | Europe PMC

Search this title in

Google Scholar