Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus)

Busche A, Neddens J, Dinter C, Dawirs RR, Teuchert-Noodt G (2002)
DEVELOPMENTAL NEUROSCIENCE 24(6): 512-521.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Environmental experience and drugs are two parameters that affect the maturation of neurotransmitter systems. The influence of impoverished rearing (IR) versus enriched rearing (ER) was compared in conjunction with postnatal methamphetamine (MA) treatment. The densities of immunostained 5-HT fibres were quantified in septal and temporal regions of the hippocampal dentate gyrus (DG) in young adult gerbils. In the IR group, 5-HT fibre densities were significantly increased in the molecular, granular and polymorphic layers of the DG in the temporal plane. After postnatal MA treatment, the 5-HT fibre density in the ER group reached a level equivalent to that of the IR group in nearly all respects. Under IR conditions, the pharmacological intervention significantly increased the maturation of fibre densities in septal layers only in the right hemisphere with no significant alterations in the left hemisphere and in temporal regions of either hemisphere. According to our previous studies on hippocampal neurogenesis, adaptations of 5-HT fibre densities partly proved to be positively correlated to cell proliferation rates for each of the specific conditions. Thus, the induced MA sensitivity, caused by pharmacological intervention at day 14, was manifested as direct interaction of 5-HT fibre maturation and cell proliferation in dependence of environmental factors. Both IR and MA together give us a better understanding of raphe-hippocampal plasticity and offer new perspectives for pharmacological studies on the 5-HT participation in mental disorders. Copyright (C) 2002 S. Karger AG, Basel.
Erscheinungsjahr
Zeitschriftentitel
DEVELOPMENTAL NEUROSCIENCE
Band
24
Zeitschriftennummer
6
Seite
512-521
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Busche A, Neddens J, Dinter C, Dawirs RR, Teuchert-Noodt G. Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus). DEVELOPMENTAL NEUROSCIENCE. 2002;24(6):512-521.
Busche, A., Neddens, J., Dinter, C., Dawirs, R. R., & Teuchert-Noodt, G. (2002). Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus). DEVELOPMENTAL NEUROSCIENCE, 24(6), 512-521. doi:10.1159/000069362
Busche, A., Neddens, J., Dinter, C., Dawirs, R. R., and Teuchert-Noodt, G. (2002). Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus). DEVELOPMENTAL NEUROSCIENCE 24, 512-521.
Busche, A., et al., 2002. Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus). DEVELOPMENTAL NEUROSCIENCE, 24(6), p 512-521.
A. Busche, et al., “Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus)”, DEVELOPMENTAL NEUROSCIENCE, vol. 24, 2002, pp. 512-521.
Busche, A., Neddens, J., Dinter, C., Dawirs, R.R., Teuchert-Noodt, G.: Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus). DEVELOPMENTAL NEUROSCIENCE. 24, 512-521 (2002).
Busche, A, Neddens, J, Dinter, C, Dawirs, RR, and Teuchert-Noodt, Gertraud. “Differential influence of rearing conditions and methamphetamine on serotonin fibre maturation in the dentate gyrus of gerbils (Meriones unguiculatus)”. DEVELOPMENTAL NEUROSCIENCE 24.6 (2002): 512-521.

13 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Developmental neuroplasticity and the origin of neurodegenerative diseases.
Schaefers AT, Teuchert-Noodt G., World J Biol Psychiatry 17(8), 2016
PMID: 23705632
Activity-dependent structural plasticity.
Butz M, Wörgötter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072
The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors.
Busche A, Bagorda A, Lehmann K, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 113(2), 2006
PMID: 15959847
Association between body weight of newborn rats and density of serotonin transporters in the frontal cortex at adulthood.
Himpel S, Bartels J, Zimdars K, Huether G, Adler L, Dawirs RR, Moll GH., J Neural Transm (Vienna) 113(3), 2006
PMID: 15997417
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
Offer and demand: proliferation and survival of neurons in the dentate gyrus.
Lehmann K, Butz M, Teuchert-Noodt G., Eur J Neurosci 21(12), 2005
PMID: 16026459
Postnatal maturation of cortical serotonin lateral asymmetry in gerbils is vulnerable to both environmental and pharmacological epigenetic challenges.
Neddens J, Dawirs RR, Bagorda F, Busche A, Horstmann S, Teuchert-Noodt G., Brain Res 1021(2), 2004
PMID: 15342268

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