Association between infections and signs and symptoms of 'atopic' hypersensitivity - results of a cross-sectional survey among first-year university students in Germany and Spain

Uter W, Stock C, Pfahlberg A, Guillen-Grima F, Aguinaga-Ontoso I, Brun-Sandiumenge C, Krämer A (2003)
Allergy 58(7): 580-584.

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Abstract
Background: This study assessed the hypothesis that a decreased exposure to childhood infectious diseases is associated with signs and symptoms of 'atopic' hypersensitivity diseases. Methods: A cross-sectional survey was performed among 1368 Spanish and German first-year university students between 1997 and 1999, including self-administered questionnaire data and serological tests. Results: No association between the disease outcomes and hepatitis A, Helicobacter pylori infection and herpes simplex infection was observed in logistic regression analyses, adjusting for potential confounders (centre, sex, smoking, parental education). In contrast, vaccination against hepatitis B was associated with a decreased risk for the outcomes allergic rhinitis (OR 0.63, 95% CI: 0.42-0.95) and total serum IgE above 100 U/ml (OR 0.56, 95% CI: 0.39-0.81). Conversely, seropositivity to HBc antigen was significantly associated with high total serum IgE (OR 2.04, 95% CI: 1.34-3.06). Conclusions: Our study partly confirmed and partly contradicted previous evidence and hypotheses, respectively, concerning the role of the infections considered. The observation of a decreased risk in persons vaccinated against hepatitis B warrants further, prospective investigation.
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Uter W, Stock C, Pfahlberg A, et al. Association between infections and signs and symptoms of 'atopic' hypersensitivity - results of a cross-sectional survey among first-year university students in Germany and Spain. Allergy. 2003;58(7):580-584.
Uter, W., Stock, C., Pfahlberg, A., Guillen-Grima, F., Aguinaga-Ontoso, I., Brun-Sandiumenge, C., & Krämer, A. (2003). Association between infections and signs and symptoms of 'atopic' hypersensitivity - results of a cross-sectional survey among first-year university students in Germany and Spain. Allergy, 58(7), 580-584.
Uter, W., Stock, C., Pfahlberg, A., Guillen-Grima, F., Aguinaga-Ontoso, I., Brun-Sandiumenge, C., and Krämer, A. (2003). Association between infections and signs and symptoms of 'atopic' hypersensitivity - results of a cross-sectional survey among first-year university students in Germany and Spain. Allergy 58, 580-584.
Uter, W., et al., 2003. Association between infections and signs and symptoms of 'atopic' hypersensitivity - results of a cross-sectional survey among first-year university students in Germany and Spain. Allergy, 58(7), p 580-584.
W. Uter, et al., “Association between infections and signs and symptoms of 'atopic' hypersensitivity - results of a cross-sectional survey among first-year university students in Germany and Spain”, Allergy, vol. 58, 2003, pp. 580-584.
Uter, W., Stock, C., Pfahlberg, A., Guillen-Grima, F., Aguinaga-Ontoso, I., Brun-Sandiumenge, C., Krämer, A.: Association between infections and signs and symptoms of 'atopic' hypersensitivity - results of a cross-sectional survey among first-year university students in Germany and Spain. Allergy. 58, 580-584 (2003).
Uter, W., Stock, Christiane, Pfahlberg, A., Guillen-Grima, F., Aguinaga-Ontoso, I., Brun-Sandiumenge, C., and Krämer, Alexander. “Association between infections and signs and symptoms of 'atopic' hypersensitivity - results of a cross-sectional survey among first-year university students in Germany and Spain”. Allergy 58.7 (2003): 580-584.
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Oszukowska M, Michalak I, Gutfreund K, Bienias W, Matych M, Szewczyk A, Kaszuba A., Postepy Dermatol Alergol 32(6), 2015
PMID: 26755903
Helicobacter pylori and allergy: Update of research.
Daugule I, Zavoronkova J, Santare D., World J Methodol 5(4), 2015
PMID: 26713280
Is Helicobacter Pylori infection inversely associated with atopy? A systematic review and meta-analysis.
Taye B, Enquselassie F, Tsegaye A, Medhin G, Davey G, Venn A., Clin. Exp. Allergy 45(5), 2015
PMID: 25207960
The association between asthma and Helicobacter pylori: a meta-analysis.
Wang Q, Yu C, Sun Y., Helicobacter 18(1), 2013
PMID: 23067334
Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study.
Veiga RV, Cunha SS, Dattoli VC, Cruz AC, Cooper PJ, Rodrigues LC, Barreto ML, Alcantara-Neves NM., BMC Pulm Med 11(), 2011
PMID: 21569568
Hepatitis B virus surface antigen can activate dendritic cells and modulate T helper type immune response.
Jan RH, Lin YL, Chen LK, Huang MT, Wang LC, Chiang BL., Microbiol. Immunol. 55(1), 2011
PMID: 21175774
Helicobacter pylori in allergic inflammation--fact or fiction?
Baccioglu A, Kalpaklioglu F, Guliter S, Yakaryilmaz F., Allergol Immunopathol (Madr) 36(2), 2008
PMID: 18479660
The effect of infectious burden on the prevalence of atopy and respiratory allergies in Iceland, Estonia, and Sweden.
Janson C, Asbjornsdottir H, Birgisdottir A, Sigurjonsdottir RB, Gunnbjornsdottir M, Gislason D, Olafsson I, Cook E, Jogi R, Gislason T, Thjodleifsson B., J. Allergy Clin. Immunol. 120(3), 2007
PMID: 17586034
Viral infections and allergies.
Xepapadaki P, Papadopoulos NG., Immunobiology 212(6), 2007
PMID: 17544830
Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?
Flohr C, Pascoe D, Williams HC., Br. J. Dermatol. 152(2), 2005
PMID: 15727630
The hygiene hypothesis and asthma.
Ramsey CD, Celedon JC., Curr Opin Pulm Med 11(1), 2005
PMID: 15591883
Association of hepatitis A virus infection with allergic sensitization in a population with high prevalence of hepatitis A virus exposure.
Gonzalez-Quintela A, Gude F, Boquete O, Aguilera A, Rey J, Meijide LM, Fernandez-Merino MC, Vidal C., Allergy 60(1), 2005
PMID: 15575938
Helicobacter pylori and extragastric diseases--other Helicobacters.
Gasbarrini A, Carloni E, Gasbarrini G, Chisholm SA., Helicobacter 9 Suppl 1(), 2004
PMID: 15347307
The hygiene theory: fact or fiction?
Sheikh A, Strachan DP., Curr Opin Otolaryngol Head Neck Surg 12(3), 2004
PMID: 15167035
Asthma and atopy - the price of affluence?
Von Hertzen LC, Haahtela T., Allergy 59(2), 2004
PMID: 14763924

14 References

Data provided by Europe PubMed Central.


AUTHOR UNKNOWN, 0
Allergy, parasites, and the hygiene hypothesis.
Yazdanbakhsh M, Kremsner PG, van Ree R., Science 296(5567), 2002
PMID: 11964470
Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study.
Scrivener S, Yemaneberhan H, Zebenigus M, Tilahun D, Girma S, Ali S, McElroy P, Custovic A, Woodcock A, Pritchard D, Venn A, Britton J., Lancet 358(9292), 2001
PMID: 11705561
Childhood exposure to infection and risk of adult onset wheeze and atopy.
Bodner C, Anderson WJ, Reid TS, Godden DJ., Thorax 55(5), 2000
PMID: 10770819

Matricardi, Br Med J 314(), 1997
Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study.
Matricardi PM, Rosmini F, Riondino S, Fortini M, Ferrigno L, Rapicetta M, Bonini S., BMJ 320(7232), 2000
PMID: 10669445
Assessment of long-term efficacy of hepatitis B vaccine.
Ayerbe MC, Perez-Rivilla A; ICOVAHB group., Eur. J. Epidemiol. 17(2), 2001
PMID: 11599689
Family size, day-care attendance, and breastfeeding in relation to the incidence of childhood asthma.
Infante-Rivard C, Amre D, Gautrin D, Malo JL., Am. J. Epidemiol. 153(7), 2001
PMID: 11282792
Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood.
Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, Yamaoka Y, Berenson GS., Lancet 359(9310), 2002
PMID: 11918912

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