Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder

Driessen M, Beblo T, Mertens M, Piefke M, Rullkoetter N, Silva-Saavedra A, Reddemann L, Rau H, Markowitsch HJ, Wulff H, Lange W, et al. (2004)
BIOLOGICAL PSYCHIATRY 55(6): 603-611.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Background: Early traumatization and additional Posttraumatic stress disorder are frequent inpatients with borderline personality disorder (BPD). The purpose of this study was to investigate neural correlates of traumatic memory in BPD with and without posttraumatic stress disorder (PTSD) using functional magnetic resonance imaging (fMRI). Methods: We studied 12 traumatized female patients BPD, 6 of them with and 6 without PTSD. According to an autobiographical interview key words (cues) were defined for traumatic and for negative but nontraumatic episodes. In a block-designed fMRI task patients recalled these episodes. Contrasts between trauma condition and nontrauma condition were analyzed. Results: Analyses for all subjects revealed activation of orbitofrontal cortex areas in both hemispheres, anterior temporal lobes, and occipital areas. In the subgroup without PTSD, activation of orbitofrontal cortex on both sides and Broca's area predominated. In the subgroup with additional PTSD, we observed right more than left activation of anterior temporal lobes, mesiotemporal areas, amygdala, posterior cingulate gyrus, occipital areas, and cerebellum. Conclusions: Dependent on absence or presence of additional PTSD different neural networks seem to be involved in the traumatic memory of patients with BPD.
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Zeitschriftentitel
BIOLOGICAL PSYCHIATRY
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55
Zeitschriftennummer
6
Seite
603-611
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Driessen M, Beblo T, Mertens M, et al. Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder. BIOLOGICAL PSYCHIATRY. 2004;55(6):603-611.
Driessen, M., Beblo, T., Mertens, M., Piefke, M., Rullkoetter, N., Silva-Saavedra, A., Reddemann, L., et al. (2004). Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder. BIOLOGICAL PSYCHIATRY, 55(6), 603-611. doi:10.1016/j.biopsych.2003.08.018
Driessen, M., Beblo, T., Mertens, M., Piefke, M., Rullkoetter, N., Silva-Saavedra, A., Reddemann, L., Rau, H., Markowitsch, H. J., Wulff, H., et al. (2004). Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder. BIOLOGICAL PSYCHIATRY 55, 603-611.
Driessen, M., et al., 2004. Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder. BIOLOGICAL PSYCHIATRY, 55(6), p 603-611.
M. Driessen, et al., “Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder”, BIOLOGICAL PSYCHIATRY, vol. 55, 2004, pp. 603-611.
Driessen, M., Beblo, T., Mertens, M., Piefke, M., Rullkoetter, N., Silva-Saavedra, A., Reddemann, L., Rau, H., Markowitsch, H.J., Wulff, H., Lange, W., Woermann, F.G.: Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder. BIOLOGICAL PSYCHIATRY. 55, 603-611 (2004).
Driessen, Martin, Beblo, Thomas, Mertens, M, Piefke, Martina, Rullkoetter, N, Silva-Saavedra, A, Reddemann, L, Rau, H, Markowitsch, Hans J., Wulff, H, Lange, W, and Woermann, FG. “Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder”. BIOLOGICAL PSYCHIATRY 55.6 (2004): 603-611.

58 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Neuroimaging in borderline personality disorder.
Schmahl C, Bremner JD., J Psychiatr Res 40(5), 2006
PMID: 16239012
Neurobiology of dissociation: unity and disunity in mind-body-brain.
Frewen PA, Lanius RA., Psychiatr Clin North Am 29(1), 2006
PMID: 16530589
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD.
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PMID: 16891563

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