Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis

Diehl P, Hantke B, Hennig M, Tschesche H, Mittelmeier W, Schmitt M, Muehlenweg B (2004)
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13(5): 711-715.

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Abstract
Matrix metalloproteinase 13 (MMP-13), urokinase type plasminogen activator (uPA), and plasminogen activator inhibitor type-1 (PAI-1) have been reported to be involved in aseptic loosening of artificial hip joints. This study for the first time presents the protein levels of all of these factors in synovial-like interfaces between bone and prosthesis and in pseudocapsular tissues surrounding the artificial joint in patients with aseptic loosening (n=17) measured by ELISA. No differences were observed in the antigen expression of MMP-13, uPA, and PAI-1, comparing interface and pseudocapsular tissue. Also, no significant correlation between the protein expression of these factors and years from arthroplasty to revision or to type of fixation (cemented vs. cementless) was observed. As control, MMP-13, uPA, and PAI-1 antigen levels were also determined in the synovium of patients with osteoarthritis (n=10). Yet, the antigen levels of MMP-13, uPA, and PAI-1 in tissue specimens from patients with aseptic loosening of artificial hip joints were significantly higher compared to their expression in synovial capsular tissues obtained from patients with osteoarthritis. In conclusion, this study shows that elevated protein levels of uPA, PAI-1, and MMP-13 in periprosthetic pseudocapsular and interface tissues from patients after total hip replacement due to aseptic loosening seem not to be associated with the patient outcome.
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Diehl P, Hantke B, Hennig M, et al. Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2004;13(5):711-715.
Diehl, P., Hantke, B., Hennig, M., Tschesche, H., Mittelmeier, W., Schmitt, M., & Muehlenweg, B. (2004). Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 13(5), 711-715.
Diehl, P., Hantke, B., Hennig, M., Tschesche, H., Mittelmeier, W., Schmitt, M., and Muehlenweg, B. (2004). Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13, 711-715.
Diehl, P., et al., 2004. Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 13(5), p 711-715.
P. Diehl, et al., “Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis”, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 13, 2004, pp. 711-715.
Diehl, P., Hantke, B., Hennig, M., Tschesche, H., Mittelmeier, W., Schmitt, M., Muehlenweg, B.: Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 13, 711-715 (2004).
Diehl, P, Hantke, B, Hennig, M, Tschesche, Harald, Mittelmeier, W, Schmitt, M, and Muehlenweg, B. “Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis”. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13.5 (2004): 711-715.
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Effect of lentivirus-mediated uPA silencing on the proliferation and apoptosis of chondrocytes and the expression of MMPs.
Shi CH, Wang WS, Zhang ZD, Li CJ, Guo FJ, Li F, Chen AM., J. Huazhong Univ. Sci. Technol. Med. Sci. 35(1), 2015
PMID: 25673203
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Diehl P, Haenle M, Bergschmidt P, Gollwitzer H, Schauwecker J, Bader R, Mittelmeier W., Biomed Tech (Berl) 55(5), 2010
PMID: 20958235
Cementless total hip replacement: a prospective clinical study of the early functional and radiological outcomes of three different hip stems.
Bergschmidt P, Bader R, Finze S, Gankovych A, Kundt G, Mittelmeier W., Arch Orthop Trauma Surg 130(1), 2010
PMID: 19526245

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