Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies

Jenssen K, Sewald K, Sewald N (2004)
BIOCONJUGATE CHEMISTRY 15(3): 594-600.

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Abstract
Immobilized small-molecule inhibitors are suited for enrichment of biomolecules by affinity chromatography, as it is shown for metalloproteinases and an immobilizable derivative of the hydroxamate-type inhibitor marimastat. A new asymmetric synthesis of marimastat is presented that allows for site-specific attachment to a solid surface, e.g., a chromatography matrix or a surface plasmon resonance sensor chip. The latter technique is shown to be a valuable tool for the optimization of binding and elution conditons of biomolecules in affinity chromatography.
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Jenssen K, Sewald K, Sewald N. Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies. BIOCONJUGATE CHEMISTRY. 2004;15(3):594-600.
Jenssen, K., Sewald, K., & Sewald, N. (2004). Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies. BIOCONJUGATE CHEMISTRY, 15(3), 594-600.
Jenssen, K., Sewald, K., and Sewald, N. (2004). Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies. BIOCONJUGATE CHEMISTRY 15, 594-600.
Jenssen, K., Sewald, K., & Sewald, N., 2004. Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies. BIOCONJUGATE CHEMISTRY, 15(3), p 594-600.
K. Jenssen, K. Sewald, and N. Sewald, “Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies”, BIOCONJUGATE CHEMISTRY, vol. 15, 2004, pp. 594-600.
Jenssen, K., Sewald, K., Sewald, N.: Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies. BIOCONJUGATE CHEMISTRY. 15, 594-600 (2004).
Jenssen, K, Sewald, K, and Sewald, Norbert. “Synthesis of marimastat and a marimastat conjugate for affinity chromatography and surface plasmon resonance studies”. BIOCONJUGATE CHEMISTRY 15.3 (2004): 594-600.
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