An improved method for the solution cyclization of peptides under pseudo-high dilution conditions

Malesevic M, Strijowski U, Bachle D, Sewald N (2004)
JOURNAL OF BIOTECHNOLOGY 112(1-2): 73-77.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ;
Abstract
Depending on the ring size, the cyclization of peptides often is accompanied by dimerization or cyclodimerization. Hence, these macrocyclizations have to be performed under high dilution conditions. Efficient cyclization of peptides in solution with a minimum amount of solvent succeeds, when a dual syringe pump is used to simultaneously add the linear peptide precursor and a coupling reagent from two separate syringes. (C) 2004 Elsevier B.V. All rights reserved.
Publishing Year
ISSN
PUB-ID

Cite this

Malesevic M, Strijowski U, Bachle D, Sewald N. An improved method for the solution cyclization of peptides under pseudo-high dilution conditions. JOURNAL OF BIOTECHNOLOGY. 2004;112(1-2):73-77.
Malesevic, M., Strijowski, U., Bachle, D., & Sewald, N. (2004). An improved method for the solution cyclization of peptides under pseudo-high dilution conditions. JOURNAL OF BIOTECHNOLOGY, 112(1-2), 73-77.
Malesevic, M., Strijowski, U., Bachle, D., and Sewald, N. (2004). An improved method for the solution cyclization of peptides under pseudo-high dilution conditions. JOURNAL OF BIOTECHNOLOGY 112, 73-77.
Malesevic, M., et al., 2004. An improved method for the solution cyclization of peptides under pseudo-high dilution conditions. JOURNAL OF BIOTECHNOLOGY, 112(1-2), p 73-77.
M. Malesevic, et al., “An improved method for the solution cyclization of peptides under pseudo-high dilution conditions”, JOURNAL OF BIOTECHNOLOGY, vol. 112, 2004, pp. 73-77.
Malesevic, M., Strijowski, U., Bachle, D., Sewald, N.: An improved method for the solution cyclization of peptides under pseudo-high dilution conditions. JOURNAL OF BIOTECHNOLOGY. 112, 73-77 (2004).
Malesevic, M, Strijowski, U, Bachle, D, and Sewald, Norbert. “An improved method for the solution cyclization of peptides under pseudo-high dilution conditions”. JOURNAL OF BIOTECHNOLOGY 112.1-2 (2004): 73-77.
This data publication is cited in the following publications:
This publication cites the following data publications:

15 Citations in Europe PMC

Data provided by Europe PubMed Central.

Isolation and Synthesis of Laxaphycin B-Type Peptides: A Case Study and Clues to Their Biosynthesis.
Bornancin L, Boyaud F, Mahiout Z, Bonnard I, Mills SC, Banaigs B, Inguimbert N., Mar Drugs 13(12), 2015
PMID: 26690181
Incrementally increasing the length of a peptide backbone: effect on macrocyclisation efficiency.
Ahmed MI, Harper JB, Hunter L., Org. Biomol. Chem. 12(26), 2014
PMID: 24891254
Template-constrained macrocyclic peptides prepared from native, unprotected precursors.
Lawson KV, Rose TE, Harran PG., Proc. Natl. Acad. Sci. U.S.A. 110(40), 2013
PMID: 24043790
Synthesis of constrained head-to-tail cyclic tetrapeptides by an imine-induced ring-closing/contraction strategy.
Wong CT, Lam HY, Song T, Chen G, Li X., Angew. Chem. Int. Ed. Engl. 52(39), 2013
PMID: 23934633
On-resin synthesis of an acylated and fluorescence-labeled cyclic integrin ligand for modification of poly(lactic-co-glycolic acid).
Hassert R, Hoffmeister PG, Pagel M, Hacker M, Schulz-Siegmund M, Beck-Sickinger AG., Chem. Biodivers. 9(11), 2012
PMID: 23161641
Design of cyclic peptides featuring proline predominantly in the cis conformation under physiological conditions.
Malesevic M, Schumann M, Jahreis G, Fischer G, Lucke C., Chembiochem 13(14), 2012
PMID: 22969011
Synthesis of N-methylated cyclic peptides.
Chatterjee J, Laufer B, Kessler H., Nat Protoc 7(3), 2012
PMID: 22322216
Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins αVβ3 and α5β1.
Conradi J, Huber S, Gaus K, Mertink F, Royo Gracia S, Strijowski U, Backert S, Sewald N., Amino Acids 43(1), 2012
PMID: 21915696
Synthesis, biological activity and solution structure of new analogues of the antimicrobial Gramicidin S.
Kamysz E, Mickiewicz B, Kamysz W, Bielinska S, Rodziewicz-Motowidlo S, Ciarkowski J., J. Pept. Sci. 17(3), 2011
PMID: 21308877
VCD studies on cyclic peptides assembled from L-α-amino acids and a trans-2-aminocyclopentane- or trans-2-aminocyclohexane carboxylic acid.
Vass E, Strijowski U, Wollschlager K, Mandity IM, Szilvagyi G, Jewginski M, Gaus K, Royo S, Majer Z, Sewald N, Hollosi M., J. Pept. Sci. 16(11), 2010
PMID: 20848613
The constrained amino acid beta-Acc confers potency and selectivity to integrin ligands.
Urman S, Gaus K, Yang Y, Strijowski U, Sewald N, De Pol S, Reiser O., Angew. Chem. Int. Ed. Engl. 46(21), 2007
PMID: 17394270

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 15288942
PubMed | Europe PMC

Search this title in

Google Scholar