Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes

Raible M, Evstigneev M, Reimann P, Bartels FW, Ros R (2004)
Journal of Biotechnology 112(1-2): 13-23.

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Abstract
The forced rupture of single chemical bonds in biomolecular compounds (e.g. ligand-receptor systems) as observed in dynamic force spectroscopy experiments is addressed. Under the assumption that the probability of bond rupture depends only on the instantaneously acting force, a data collapse onto a single master curve is predicted. For rupture data obtained experimentally by dynamic AFM force spectroscopy of a ligand-receptor bond between a DNA and a regulatory protein we do not find such a collapse. We conclude that the above mentioned, generally accepted assumption is not satisfied and we discuss possible explanations. (C) 2004 Elsevier B.V. All rights reserved.
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Raible M, Evstigneev M, Reimann P, Bartels FW, Ros R. Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes. Journal of Biotechnology. 2004;112(1-2):13-23.
Raible, M., Evstigneev, M., Reimann, P., Bartels, F. W., & Ros, R. (2004). Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes. Journal of Biotechnology, 112(1-2), 13-23.
Raible, M., Evstigneev, M., Reimann, P., Bartels, F. W., and Ros, R. (2004). Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes. Journal of Biotechnology 112, 13-23.
Raible, M., et al., 2004. Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes. Journal of Biotechnology, 112(1-2), p 13-23.
M. Raible, et al., “Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes”, Journal of Biotechnology, vol. 112, 2004, pp. 13-23.
Raible, M., Evstigneev, M., Reimann, P., Bartels, F.W., Ros, R.: Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes. Journal of Biotechnology. 112, 13-23 (2004).
Raible, M, Evstigneev, Mykhaylo, Reimann, Peter, Bartels, FW, and Ros, R. “Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes”. Journal of Biotechnology 112.1-2 (2004): 13-23.
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