Spindles, mitochondria and redox potential in ageing oocytes

Eichenlaub-Ritter U, Vogt E, Yin H, Gosden R (2004)
REPRODUCTIVE BIOMEDICINE ONLINE 8(1): 45-58.

Download
No fulltext has been uploaded. References only!
Journal Article | Review | Published | English

No fulltext has been uploaded

Author
; ; ;
Abstract
Studies of human oocytes obtained from women of advanced reproductive age revealed that spindles are frequently aberrant, with chromosomes sometimes failing to align properly at the equator during meiosis I and II. Chromosomal analyses of donated and spare human oocytes and cytogenetic and molecular studies on the origin of trisomies collectively suggest that errors in chromosome segregation during oogenesis increase with advancing maternal age and as the menopause approaches. Disturbances in the fidelity of chromosome segregation, especially at anaphase I, leading to aneuploidy are prime causes of reduced developmental competence of embryos in assisted reproduction, as well as being responsible for the genesis of genetic disease. This review provides an overview of spindle formation and chromosome behaviour in mammalian oocytes. Evidence of a link between abnormal mitochondrial function in oocytes and somatic follicular cells, and finally disturbances in chromosome cohesion and segregation, and cell cycle control in aged mammalian oocytes, are also discussed.
Publishing Year
ISSN
PUB-ID

Cite this

Eichenlaub-Ritter U, Vogt E, Yin H, Gosden R. Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE. 2004;8(1):45-58.
Eichenlaub-Ritter, U., Vogt, E., Yin, H., & Gosden, R. (2004). Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE, 8(1), 45-58. doi:10.1016/S1472-6483(10)60497-X
Eichenlaub-Ritter, U., Vogt, E., Yin, H., and Gosden, R. (2004). Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE 8, 45-58.
Eichenlaub-Ritter, U., et al., 2004. Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE, 8(1), p 45-58.
U. Eichenlaub-Ritter, et al., “Spindles, mitochondria and redox potential in ageing oocytes”, REPRODUCTIVE BIOMEDICINE ONLINE, vol. 8, 2004, pp. 45-58.
Eichenlaub-Ritter, U., Vogt, E., Yin, H., Gosden, R.: Spindles, mitochondria and redox potential in ageing oocytes. REPRODUCTIVE BIOMEDICINE ONLINE. 8, 45-58 (2004).
Eichenlaub-Ritter, Ursula, Vogt, E, Yin, H, and Gosden, R. “Spindles, mitochondria and redox potential in ageing oocytes”. REPRODUCTIVE BIOMEDICINE ONLINE 8.1 (2004): 45-58.
This data publication is cited in the following publications:
This publication cites the following data publications:

93 Citations in Europe PMC

Data provided by Europe PubMed Central.

Influence of follicular fluid meiosis-activating sterol on aneuploidy rate and precocious chromatid segregation in aged mouse oocytes.
Cukurcam S, Betzendahl I, Michel G, Vogt E, Hegele-Hartung C, Lindenthal B, Eichenlaub-Ritter U., Hum Reprod 22(3), 2007
PMID: 17114196
Gender differences in germ-cell mutagenesis and genetic risk.
Eichenlaub-Ritter U, Adler ID, Carere A, Pacchierotti F., Environ Res 104(1), 2007
PMID: 17156773
Age-associated changes in mouse oocytes during postovulatory in vitro culture: possible role for meiotic kinases and survival factor BCL2.
Tatone C, Carbone MC, Gallo R, Delle Monache S, Di Cola M, Alesse E, Amicarelli F., Biol Reprod 74(2), 2006
PMID: 16251501
Applications of emerging technologies to the study and conservation of threatened and endangered species.
Pukazhenthi B, Comizzoli P, Travis AJ, Wildt DE., Reprod Fertil Dev 18(1-2), 2006
PMID: 16478605
The mitochondrial contribution to stem cell biology.
Bavister BD., Reprod Fertil Dev 18(8), 2006
PMID: 17147931
Developmental effects of sublethal mitochondrial injury in mouse oocytes.
Thouas GA, Trounson AO, Jones GM., Biol Reprod 74(5), 2006
PMID: 16452460
Transmission of mitochondrial DNA following assisted reproduction and nuclear transfer.
Spikings EC, Alderson J, St John JC., Hum Reprod Update 12(4), 2006
PMID: 16581809
Comparative maturation of cynomolgus monkey oocytes in vivo and in vitro.
Yin H, Duffy DM, Gosden RG., Reprod Biol Endocrinol 4(), 2006
PMID: 16595009
Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles.
Zhang X, Wu XQ, Lu S, Guo YL, Ma X., Cell Res 16(10), 2006
PMID: 16983401
Effect of female age on mouse oocyte developmental competence following mitochondrial injury.
Thouas GA, Trounson AO, Jones GM., Biol Reprod 73(2), 2005
PMID: 15843494
Ovarian follicle bioassay reveals adverse effects of diazepam exposure upon follicle development and oocyte quality.
Van Wemmel K, Gobbers E, Eichenlaub-Ritter U, Smitz J, Cortvrindt R., Reprod Toxicol 20(2), 2005
PMID: 15907652
Origin of germ cells and formation of new primary follicles in adult human ovaries.
Bukovsky A, Caudle MR, Svetlikova M, Upadhyaya NB., Reprod Biol Endocrinol 2(), 2004
PMID: 15115550
Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro.
Thouas GA, Trounson AO, Wolvetang EJ, Jones GM., Biol Reprod 71(6), 2004
PMID: 15286028
Aging of oocyte, ovary, and human reproduction.
Ottolenghi C, Uda M, Hamatani T, Crisponi L, Garcia JE, Ko M, Pilia G, Sforza C, Schlessinger D, Forabosco A., Ann N Y Acad Sci 1034(), 2004
PMID: 15731305

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 14759287
PubMed | Europe PMC

Search this title in

Google Scholar