Decision-making impairments in patients with Parkinson's disease

Brand M, Labudda K, Kalbe E, Hilker R, Emmans D, Fuchs G, Kessler J, Markowitsch HJ (2004)
BEHAVIOURAL NEUROLOGY 15(3-4): 77-85.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ; ; ;
Abstract / Bemerkung
A high percentage of Parkinson's disease (PD) patients show cognitive impairments in addition to the cardinal motor symptoms. These deficits primarily concern executive functions most probably linked to dysfunctions in prefrontal regions due to decreased dopaminergic transmission in fronto-striatal loops. To investigate possible associations between decision-making and executive functions in PD, we examined 20 non-demented PD patients and 20 healthy control subjects with a neuropsychological test battery and the Game of Dice Task. In this computerised decision-making task, the rules for gains and losses and the winning probabilities are obvious and stable. Thus, strategic components besides feedback processing might influence decision making in this task. We found that PD patients were impaired in the Game of Dice task performance and that the frequency of disadvantageous choices correlated with both executive functions and feedback processing. We suggest that decision-making deficits of PD patients in explicit gambling situations might be associated with dysfunctions in two different fronto-striatal loops: the limbic-orbitofrontal-striatal loop, involved in feedback processing, and the dorsolateral prefrontal-striatal loop, involved in executive functions.
Erscheinungsjahr
Zeitschriftentitel
BEHAVIOURAL NEUROLOGY
Band
15
Zeitschriftennummer
3-4
Seite
77-85
ISSN
eISSN
PUB-ID

Zitieren

Brand M, Labudda K, Kalbe E, et al. Decision-making impairments in patients with Parkinson's disease. BEHAVIOURAL NEUROLOGY. 2004;15(3-4):77-85.
Brand, M., Labudda, K., Kalbe, E., Hilker, R., Emmans, D., Fuchs, G., Kessler, J., et al. (2004). Decision-making impairments in patients with Parkinson's disease. BEHAVIOURAL NEUROLOGY, 15(3-4), 77-85. doi:10.1155/2004/578354
Brand, M., Labudda, K., Kalbe, E., Hilker, R., Emmans, D., Fuchs, G., Kessler, J., and Markowitsch, H. J. (2004). Decision-making impairments in patients with Parkinson's disease. BEHAVIOURAL NEUROLOGY 15, 77-85.
Brand, M., et al., 2004. Decision-making impairments in patients with Parkinson's disease. BEHAVIOURAL NEUROLOGY, 15(3-4), p 77-85.
M. Brand, et al., “Decision-making impairments in patients with Parkinson's disease”, BEHAVIOURAL NEUROLOGY, vol. 15, 2004, pp. 77-85.
Brand, M., Labudda, K., Kalbe, E., Hilker, R., Emmans, D., Fuchs, G., Kessler, J., Markowitsch, H.J.: Decision-making impairments in patients with Parkinson's disease. BEHAVIOURAL NEUROLOGY. 15, 77-85 (2004).
Brand, M, Labudda, Kirsten, Kalbe, E, Hilker, R, Emmans, D, Fuchs, G, Kessler, J, and Markowitsch, Hans J. “Decision-making impairments in patients with Parkinson's disease”. BEHAVIOURAL NEUROLOGY 15.3-4 (2004): 77-85.

93 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Decision making in patients with temporal lobe epilepsy.
Labudda K, Frigge K, Horstmann S, Aengenendt J, Woermann FG, Ebner A, Markowitsch HJ, Brand M., Neuropsychologia 47(1), 2009
PMID: 18789345
Decision-making on an explicit risk-taking task in preadolescents with attention-deficit/hyperactivity disorder.
Drechsler R, Rizzo P, Steinhausen HC., J Neural Transm (Vienna) 115(2), 2008
PMID: 17885724
The role of strategies in deciding advantageously in ambiguous and risky situations.
Brand M, Heinze K, Labudda K, Markowitsch HJ., Cogn Process 9(3), 2008
PMID: 18231817
Impact of ambiguity and risk on decision making in mild Alzheimer's disease.
Sinz H, Zamarian L, Benke T, Wenning GK, Delazer M., Neuropsychologia 46(7), 2008
PMID: 18339408
Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects.
Labudda K, Woermann FG, Mertens M, Pohlmann-Eden B, Markowitsch HJ, Brand M., Exp Brain Res 187(4), 2008
PMID: 18320179
Specific impairments in the recognition of emotional facial expressions in Parkinson's disease.
Clark US, Neargarder S, Cronin-Golomb A., Neuropsychologia 46(9), 2008
PMID: 18485422
Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition.
Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, Fallon S, Barker RA, Owen AM., Brain 131(pt 8), 2008
PMID: 18577547
Role of the amygdala in decisions under ambiguity and decisions under risk: evidence from patients with Urbach-Wiethe disease.
Brand M, Grabenhorst F, Starcke K, Vandekerckhove MM, Markowitsch HJ., Neuropsychologia 45(6), 2007
PMID: 17070876
Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease.
Smeding HM, Goudriaan AE, Foncke EM, Schuurman PR, Speelman JD, Schmand B., J Neurol Neurosurg Psychiatry 78(5), 2007
PMID: 17210626
Decision-making with explicit and stable rules in mild Alzheimer's disease.
Delazer M, Sinz H, Zamarian L, Benke T., Neuropsychologia 45(8), 2007
PMID: 17328931
Dissociation of emotional decision-making from cognitive decision-making in chronic schizophrenia.
Lee Y, Kim YT, Seo E, Park O, Jeong SH, Kim SH, Lee SJ., Psychiatry Res 152(2-3), 2007
PMID: 17462743
Decision-making in Parkinson's disease.
Witt K., Mov Disord 22(10), 2007
PMID: 17523197
Executive system dysfunction occurs as early as middle-age in the rhesus monkey.
Moore TL, Killiany RJ, Herndon JG, Rosene DL, Moss MB., Neurobiol Aging 27(10), 2006
PMID: 16183172
Disgust-specific impairment of facial expression recognition in Parkinson's disease.
Suzuki A, Hoshino T, Shigemasu K, Kawamura M., Brain 129(pt 3), 2006
PMID: 16415306
Impaired decision-making in Parkinson's disease.
Mimura M, Oeda R, Kawamura M., Parkinsonism Relat Disord 12(3), 2006
PMID: 16563850
Training of executive functions in Parkinson's disease.
Sammer G, Reuter I, Hullmann K, Kaps M, Vaitl D., J Neurol Sci 248(1-2), 2006
PMID: 16765378
Impulse control disorders in Parkinson's disease.
Weintraub D, Potenza MN., Curr Neurol Neurosci Rep 6(4), 2006
PMID: 16822350
Neuropsychological correlates of decision-making in ambiguous and risky situations.
Brand M, Labudda K, Markowitsch HJ., Neural Netw 19(8), 2006
PMID: 16942857

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 15706051
PubMed | Europe PMC

Suchen in

Google Scholar