Oxygenation alters ganglioside expression in rat liver following partial hepatectomy

Markotic A, Culic VC, Kurir TT, Meisen I, Büntemeyer H, Boraska V, Zemunik T, Petri N, Mesaric M, Peter-Katalinic J, Müthing J (2005)
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330(1): 131-141.

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Gangliosides from livers of weanling rats were analyzed after 15% partial hepatectomy (PH) and different pre- and post-operative hyberbaric oxygenation (pre- and postHBO). Neu5Ac was the predominant ganglioside-derived sialic acid (> 85%) compared to Neu5Gc. Almost identical low total sialic acid content (Neu5Ac + Neu5Gc) of the control and operated nonHBO animals opposed a 6.4- to 7.6-fold increase in pre- and postHBO animals (69.26 and 81.64 pmol/mg wet weight, respectively). NanoESI-QTOF mass spectrometry combined with HPTLC immunostaining revealed GM3(Neu5Ac) and GM3(Neu5Gc) as major gangliosides, correlating with the respective sialic acid concentrations. Minor neolacto-series gangliosides were enhanced in preHBO and postHBO, but GM1-core gangliosides only in preHBO rats. GM2 and Ga1NAc-GM1b were clearly detectable in oxygenated rats compared to traces in the control and nonHBO animals. These results point at a functional role of gangliosides in liver growth regulation and reconstitution after PH combined with pre- and post-operative HBO treatment. (c) 2005 Elsevier Inc. All rights reserved.
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Markotic A, Culic VC, Kurir TT, et al. Oxygenation alters ganglioside expression in rat liver following partial hepatectomy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;330(1):131-141.
Markotic, A., Culic, V. C., Kurir, T. T., Meisen, I., Büntemeyer, H., Boraska, V., Zemunik, T., et al. (2005). Oxygenation alters ganglioside expression in rat liver following partial hepatectomy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 330(1), 131-141.
Markotic, A., Culic, V. C., Kurir, T. T., Meisen, I., Büntemeyer, H., Boraska, V., Zemunik, T., Petri, N., Mesaric, M., Peter-Katalinic, J., et al. (2005). Oxygenation alters ganglioside expression in rat liver following partial hepatectomy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330, 131-141.
Markotic, A., et al., 2005. Oxygenation alters ganglioside expression in rat liver following partial hepatectomy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 330(1), p 131-141.
A. Markotic, et al., “Oxygenation alters ganglioside expression in rat liver following partial hepatectomy”, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 330, 2005, pp. 131-141.
Markotic, A., Culic, V.C., Kurir, T.T., Meisen, I., Büntemeyer, H., Boraska, V., Zemunik, T., Petri, N., Mesaric, M., Peter-Katalinic, J., Müthing, J.: Oxygenation alters ganglioside expression in rat liver following partial hepatectomy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 330, 131-141 (2005).
Markotic, A, Culic, VC, Kurir, TT, Meisen, I, Büntemeyer, Heino, Boraska, V, Zemunik, T, Petri, N, Mesaric, M, Peter-Katalinic, J, and Müthing, Johannes. “Oxygenation alters ganglioside expression in rat liver following partial hepatectomy”. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330.1 (2005): 131-141.
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