Adaptation of Corynebacterium glutamicum to ammonium limitation: A global analysis using transcriptome and proteome techniques

Silberbach M, Schafer M, Hüser AT, Kalinowski J, Pühler A, Kramer R, Burkovski A (2005)
APPLIED AND ENVIRONMENTAL MICROBIOLOGY 71(5): 2391-2402.

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The response of Corynebacterium glutamicum to ammonium limitation was studied by transcriptional and proteome profiling of cells grown in a chemostat. Our results show that ammonium-limited growth of C. glutamicum results in a rearrangement of the cellular transport capacity, changes in metabolic pathways for nitrogen assimilation, amino acid biosynthesis, and carbon metabolism, as well as a decreased cell division. Since transcription at different growth rates was studied, it was possible to distinguish specific responses to ammonium limitation and more general, growth rate-dependent alterations in gene expression. The latter include a number of genes encoding ribosomal proteins and genes for F0F1-ATP synthase subunits.
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Silberbach M, Schafer M, Hüser AT, et al. Adaptation of Corynebacterium glutamicum to ammonium limitation: A global analysis using transcriptome and proteome techniques. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2005;71(5):2391-2402.
Silberbach, M., Schafer, M., Hüser, A. T., Kalinowski, J., Pühler, A., Kramer, R., & Burkovski, A. (2005). Adaptation of Corynebacterium glutamicum to ammonium limitation: A global analysis using transcriptome and proteome techniques. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71(5), 2391-2402. doi:10.1128/AEM.71.5.2391-2402.2005
Silberbach, M., Schafer, M., Hüser, A. T., Kalinowski, J., Pühler, A., Kramer, R., and Burkovski, A. (2005). Adaptation of Corynebacterium glutamicum to ammonium limitation: A global analysis using transcriptome and proteome techniques. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 71, 2391-2402.
Silberbach, M., et al., 2005. Adaptation of Corynebacterium glutamicum to ammonium limitation: A global analysis using transcriptome and proteome techniques. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71(5), p 2391-2402.
M. Silberbach, et al., “Adaptation of Corynebacterium glutamicum to ammonium limitation: A global analysis using transcriptome and proteome techniques”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 71, 2005, pp. 2391-2402.
Silberbach, M., Schafer, M., Hüser, A.T., Kalinowski, J., Pühler, A., Kramer, R., Burkovski, A.: Adaptation of Corynebacterium glutamicum to ammonium limitation: A global analysis using transcriptome and proteome techniques. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 71, 2391-2402 (2005).
Silberbach, M., Schafer, M., Hüser, Andrea T., Kalinowski, Jörn, Pühler, Alfred, Kramer, R., and Burkovski, A. “Adaptation of Corynebacterium glutamicum to ammonium limitation: A global analysis using transcriptome and proteome techniques”. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 71.5 (2005): 2391-2402.
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