High magnitude of light retardation by the zona pellucida is associated with conception cycles

Shen Y, Stalf T, Mehnert C, Eichenlaub-Ritter U, Tinneberg HR (2005)
HUMAN REPRODUCTION 20(6): 1596-1606.

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BACKGROUND: Failures in expression of zona proteins correlate to subfertility in animals. Low expression of the zona proteins by the growing human oocyte may indicate reduced developmental potential. Therefore, we non-invasively analysed the thickness and the structure of the zona pellucida (ZP) of human oocytes with respect to embryo fate after ICSI. METHODS: Retardance magnitude and thickness of the inner, middle and outer layers of the ZP were quantitatively analysed by a Polscope in 166 oocytes selected for transfer after ICSI (63 patients; 32.8 +/- 4.4 years) on the basis of pronuclear score at day 1. Blastomere number was determined at day 2. Data were compared between conception cycles (CC; 65 oocytes/23 patients) and non-conception cycles (NCC; 101 oocytes/40 patients) and with respect to maternal age. RESULTS: The thickness was slightly elevated (P < 0.001), and the mean magnitude of light retardance was nearly 30% higher (P < 0.001) in the inner layer of the zona pellucida of oocytes contributing to CC compared to NCC. Embryos in the CC group tended to develop faster. CONCLUSIONS: The magnitude of light retardance by the zona pellucida inner layer appears to present a unique non-invasive marker for oocyte developmental potential.
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Shen Y, Stalf T, Mehnert C, Eichenlaub-Ritter U, Tinneberg HR. High magnitude of light retardation by the zona pellucida is associated with conception cycles. HUMAN REPRODUCTION. 2005;20(6):1596-1606.
Shen, Y., Stalf, T., Mehnert, C., Eichenlaub-Ritter, U., & Tinneberg, H. R. (2005). High magnitude of light retardation by the zona pellucida is associated with conception cycles. HUMAN REPRODUCTION, 20(6), 1596-1606. doi:10.1093/humrep/deh811
Shen, Y., Stalf, T., Mehnert, C., Eichenlaub-Ritter, U., and Tinneberg, H. R. (2005). High magnitude of light retardation by the zona pellucida is associated with conception cycles. HUMAN REPRODUCTION 20, 1596-1606.
Shen, Y., et al., 2005. High magnitude of light retardation by the zona pellucida is associated with conception cycles. HUMAN REPRODUCTION, 20(6), p 1596-1606.
Y. Shen, et al., “High magnitude of light retardation by the zona pellucida is associated with conception cycles”, HUMAN REPRODUCTION, vol. 20, 2005, pp. 1596-1606.
Shen, Y., Stalf, T., Mehnert, C., Eichenlaub-Ritter, U., Tinneberg, H.R.: High magnitude of light retardation by the zona pellucida is associated with conception cycles. HUMAN REPRODUCTION. 20, 1596-1606 (2005).
Shen, Y, Stalf, T, Mehnert, C, Eichenlaub-Ritter, Ursula, and Tinneberg, HR. “High magnitude of light retardation by the zona pellucida is associated with conception cycles”. HUMAN REPRODUCTION 20.6 (2005): 1596-1606.
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