Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora

Tauch A, Kaiser O, Hain T, Goesmann A, Weisshaar B, Albersmeier A, Bekel T, Bischoff N, Brune I, Chakraborty T, Kalinowski J, et al. (2005)
Journal of Bacteriology 187(13): 4671-4682.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ; ; ;
All
Abstract
Corynebacterium jeikeium is a "lipophilic" and multidrug-resistant bacterial species of the human skin flora that has been recognized with increasing frequency as a serious nosocomial pathogen. Here we report the genome sequence of the clinical isolate C. jeikeium K411, which was initially recovered from the axilla of a bone marrow transplant patient. The genome of C. jeikeium K411 consists of a circular chromosome of 2,462,499 bp and the 14,323-bp bacteriocin-producing plasmid pKW4. The chromosome of C. jeikeium K411 contains 2,104 predicted coding sequences, 52% of which were considered to be orthologous with genes in the Corynebacterium glutamicum, Corynebacterium efficiens, and Corynebacterium diphtheriae genomes. These genes apparently represent the chromosomal backbone that is conserved between the four corynebacteria. Among the genes that lack an ortholog in the known corynebacterial genomes, many are located close to transposable elements or revealed an atypical G+C content, indicating that horizontal gene transfer played an important role in the acquisition of genes involved in iron and manganese homeostasis, in multidrug resistance, in bacterium-host interaction, and in virulence. Metabolic analyses of the genome sequence indicated that the "lipophilic" phenotype of C jeikeium most likely originates from the absence of fatty acid synthase and thus represents a fatty acid auxotrophy. Accordingly, both the complete gene repertoire and the deduced lifestyle of C. jeikeium K411 largely reflect the strict dependence of growth on the presence of exogenous fatty acids. The predicted virulence factors of C. jeikeium K411 are apparently involved in ensuring the availability of exogenous fatty acids by damaging the host tissue.
Publishing Year
PUB-ID

Cite this

Tauch A, Kaiser O, Hain T, et al. Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. Journal of Bacteriology. 2005;187(13):4671-4682.
Tauch, A., Kaiser, O., Hain, T., Goesmann, A., Weisshaar, B., Albersmeier, A., Bekel, T., et al. (2005). Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. Journal of Bacteriology, 187(13), 4671-4682.
Tauch, A., Kaiser, O., Hain, T., Goesmann, A., Weisshaar, B., Albersmeier, A., Bekel, T., Bischoff, N., Brune, I., Chakraborty, T., et al. (2005). Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. Journal of Bacteriology 187, 4671-4682.
Tauch, A., et al., 2005. Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. Journal of Bacteriology, 187(13), p 4671-4682.
A. Tauch, et al., “Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora”, Journal of Bacteriology, vol. 187, 2005, pp. 4671-4682.
Tauch, A., Kaiser, O., Hain, T., Goesmann, A., Weisshaar, B., Albersmeier, A., Bekel, T., Bischoff, N., Brune, I., Chakraborty, T., Kalinowski, J., Meyer, F., Rupp, O., Schneiker-Bekel, S., Viehöver, P., Pühler, A.: Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. Journal of Bacteriology. 187, 4671-4682 (2005).
Tauch, Andreas, Kaiser, Olaf, Hain, Torsten, Goesmann, Alexander, Weisshaar, Bernd, Albersmeier, Andreas, Bekel, Thomas, Bischoff, Nicole, Brune, Iris, Chakraborty, Trinad, Kalinowski, Jörn, Meyer, Folker, Rupp, Oliver, Schneiker-Bekel, Susanne, Viehöver, Prisca, and Pühler, Alfred. “Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora”. Journal of Bacteriology 187.13 (2005): 4671-4682.
This data publication is cited in the following publications:
This publication cites the following data publications:

93 Citations in Europe PMC

Data provided by Europe PubMed Central.

Identification of axillary Staphylococcus sp. involved in the production of the malodorous thioalcohol 3-methyl-3-sufanylhexan-1-ol.
Bawdon D, Cox DS, Ashford D, James AG, Thomas GH., FEMS Microbiol. Lett. 362(16), 2015
PMID: 26163522
AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum.
Galimand M, Fishovitz J, Lambert T, Barbe V, Zajicek J, Mobashery S, Courvalin P., Antimicrob. Agents Chemother. 59(9), 2015
PMID: 26149994
Corynebacterium urealyticum: a comprehensive review of an understated organism.
Salem N, Salem L, Saber S, Ismail G, Bluth MH., Infect Drug Resist 8(), 2015
PMID: 26056481
Complete Genome Sequence of Corynebacterium ureicelerivorans DSM 45051, a Lipophilic and Urea-Splitting Isolate from the Blood Culture of a Septicemia Patient.
Tippelt A, Albersmeier A, Brinkrolf K, Ruckert C, Fernandez-Natal I, Soriano F, Tauch A., Genome Announc 2(6), 2014
PMID: 25414509
Whole genome sequencing indicates Corynebacterium jeikeium comprises 4 separate genomospecies and identifies a dominant genomospecies among clinical isolates.
Salipante SJ, Sengupta DJ, Cummings LA, Robinson A, Kurosawa K, Hoogestraat DR, Cookson BT., Int. J. Med. Microbiol. 304(8), 2014
PMID: 25116839
Cohabitation--relationships of corynebacteria and staphylococci on human skin.
Kwaszewska A, Sobis-Glinkowska M, Szewczyk EM., Folia Microbiol. (Praha) 59(6), 2014
PMID: 24880250
Effects of pipe materials on chlorine-resistant biofilm formation under long-term high chlorine level.
Zhu Z, Wu C, Zhong D, Yuan Y, Shan L, Zhang J., Appl. Biochem. Biotechnol. 173(6), 2014
PMID: 24828580
Macrolide, lincosamide, and streptogramin B resistance in lipophilic Corynebacteria inhabiting healthy human skin.
Szemraj M, Kwaszewska A, Pawlak R, Szewczyk EM., Microb. Drug Resist. 20(5), 2014
PMID: 24735183
Complete Genome Sequence of Corynebacterium falsenii DSM 44353 To Study the Evolution of Corynebacterium Cluster 3 Species.
Glaub A, Bomholt C, Gravermann K, Brinkrolf K, Albersmeier A, Ruckert C, Tauch A., Genome Announc 2(2), 2014
PMID: 24604654
Corynebacterium jeikeium jk0268 constitutes for the 40 amino acid long PorACj, which forms a homooligomeric and anion-selective cell wall channel.
Abdali N, Barth E, Norouzy A, Schulz R, Nau WM, Kleinekathofer U, Tauch A, Benz R., PLoS ONE 8(10), 2013
PMID: 24116064
Genomic organisation, activity and distribution analysis of the microbial putrescine oxidase degradation pathway.
Foster A, Barnes N, Speight R, Keane MA., Syst. Appl. Microbiol. 36(7), 2013
PMID: 23906496
Corynebacterium jeikeium bacteremia in a hemodialyzed patient.
Ifantidou AM, Diamantidis MD, Tseliki G, Angelou AS, Christidou P, Papa A, Pentilas D., Int. J. Infect. Dis. 14 Suppl 3(), 2010
PMID: 20171132
Identification of a terminal rhamnopyranosyltransferase (RptA) involved in Corynebacterium glutamicum cell wall biosynthesis.
Birch HL, Alderwick LJ, Rittmann D, Krumbach K, Etterich H, Grzegorzewicz A, McNeil MR, Eggeling L, Besra GS., J. Bacteriol. 191(15), 2009
PMID: 19482925
The secret of being cool.
Galperin MY., Environ. Microbiol. 7(10), 2005
PMID: 16156723

83 References

Data provided by Europe PubMed Central.

Assembly of pili in Gram-positive bacteria.
Ton-That H, Schneewind O., Trends Microbiol. 12(5), 2004
PMID: 15120142
Corynebacterium CDC group JK (Corynebacterium jeikeium) sepsis in haematological patients: a report of three cases and a systematic literature review.
van der Lelie H, Leverstein-Van Hall M, Mertens M, van Zaanen HC, van Oers RH, Thomas BL, von dem Borne AE, Kuijper EJ., Scand. J. Infect. Dis. 27(6), 1995
PMID: 8685637
Group JK corynebacteria in skin flora of healthy persons and patients.
Wichmann S, Wirsing von Koenig CH, Becker-Boost E, Finger H., Eur. J. Clin. Microbiol. 4(5), 1985
PMID: 4065137
A new subfamily of the Nudix hydrolase superfamily active on 5-methyl-UTP (ribo-TTP) and UTP.
Xu W, Shen J, Dunn CA, Bessman MJ., J. Biol. Chem. 278(39), 2003
PMID: 12871944

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 15968079
PubMed | Europe PMC

Search this title in

Google Scholar