DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum
Silberbach M, Hüser AT, Kalinowski J, Pühler A, Walter B, Kramer R, Burkovski A (2005)
JOURNAL OF BIOTECHNOLOGY 119(4): 357-367.
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Silberbach, M.
;
Hüser, Andrea T.
;
Kalinowski, JörnUniBi
;
Pühler, AlfredUniBi
;
Walter, B.
;
Kramer, R.
;
Burkovski, A.
Department
Abstract
Nitrogen is an essential component of nearly all of the complex macromolecules in a bacterial cell, e.g. proteins, nucleic acids, and cell wall components. Accordingly, most prokaryotes have developed elaborate control mechanisms to provide an optimal supply of nitrogen for cellular metabolism and to cope with situations of nitrogen limitation. In this communication, a global analysis of the Corynebacterium glutamicum nitrogen starvation response by transcriptional profiling using DNA microarrays is presented. Our results show that C. glutamicum reacts to nitrogen starvation with a rearrangement of the cellular transport capacity, changes in metabolic pathways concerning nitrogen assimilation and amino acid biosynthesis, and a decreased capacity for protein synthesis. (C) 2005 Elsevier B.V. All rights reserved.
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Silberbach M, Hüser AT, Kalinowski J, et al. DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum. JOURNAL OF BIOTECHNOLOGY. 2005;119(4):357-367.
Silberbach, M., Hüser, A. T., Kalinowski, J., Pühler, A., Walter, B., Kramer, R., & Burkovski, A. (2005). DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum. JOURNAL OF BIOTECHNOLOGY, 119(4), 357-367. doi:10.1016/j.jbiotec.2005.04.007
Silberbach, M., Hüser, A. T., Kalinowski, J., Pühler, A., Walter, B., Kramer, R., and Burkovski, A. (2005). DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum. JOURNAL OF BIOTECHNOLOGY 119, 357-367.
Silberbach, M., et al., 2005. DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum. JOURNAL OF BIOTECHNOLOGY, 119(4), p 357-367.
M. Silberbach, et al., “DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum”, JOURNAL OF BIOTECHNOLOGY, vol. 119, 2005, pp. 357-367.
Silberbach, M., Hüser, A.T., Kalinowski, J., Pühler, A., Walter, B., Kramer, R., Burkovski, A.: DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum. JOURNAL OF BIOTECHNOLOGY. 119, 357-367 (2005).
Silberbach, M., Hüser, Andrea T., Kalinowski, Jörn, Pühler, Alfred, Walter, B., Kramer, R., and Burkovski, A. “DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum”. JOURNAL OF BIOTECHNOLOGY 119.4 (2005): 357-367.
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