Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans

Brandt T, Schautzer F, Hamilton DA, Bruning R, Markowitsch HJ, Kalla R, Darlington C, Smith P, Strupp M (2005)
BRAIN 128(11): 2732-2741.

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Abstract
The human hippocampal formation plays a crucial role in various aspects of memory processing. Most literature on the human hippocampus stresses its non-spatial memory functions, but older work in rodents and some other species emphasized the role of the hippocampus in spatial learning and memory as well. A few human studies also point to a direct relation between hippocampal size, navigation and spatial memory. Conversely, the importance of the vestibular system for navigation and spatial memory was until now convincingly demonstrated only in animals. Using magnetic resonance imaging volumetry, we found that patients (n = 10) with acquired chronic bilateral vestibular loss (BVL) develop a significant selective atrophy of the hippocampus (16.9% decrease relative to controls). When tested with a virtual variant (on a PC) of the Morris water task these patients exhibited significant spatial memory and navigation deficits that closely matched the pattern of hippocampal atrophy. These spatial memory deficits were not associated with general memory deficits. The current data on BVL patients and bilateral hippocampal atrophy revive the idea that a major-and probably phylogenetically ancient-function of the archicortical hippocampal tissue is still evident in spatial aspects of memory processing for navigation. Furthermore, these data demonstrate for the first time in humans that spatial navigation critically depends on preserved vestibular function, even when the subjects are stationary, e.g. without any actual vestibular or somatosensory stimulation.
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Brandt T, Schautzer F, Hamilton DA, et al. Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. BRAIN. 2005;128(11):2732-2741.
Brandt, T., Schautzer, F., Hamilton, D. A., Bruning, R., Markowitsch, H. J., Kalla, R., Darlington, C., et al. (2005). Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. BRAIN, 128(11), 2732-2741.
Brandt, T., Schautzer, F., Hamilton, D. A., Bruning, R., Markowitsch, H. J., Kalla, R., Darlington, C., Smith, P., and Strupp, M. (2005). Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. BRAIN 128, 2732-2741.
Brandt, T., et al., 2005. Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. BRAIN, 128(11), p 2732-2741.
T. Brandt, et al., “Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans”, BRAIN, vol. 128, 2005, pp. 2732-2741.
Brandt, T., Schautzer, F., Hamilton, D.A., Bruning, R., Markowitsch, H.J., Kalla, R., Darlington, C., Smith, P., Strupp, M.: Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. BRAIN. 128, 2732-2741 (2005).
Brandt, T, Schautzer, F, Hamilton, DA, Bruning, R, Markowitsch, Hans J., Kalla, R, Darlington, C, Smith, P, and Strupp, M. “Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans”. BRAIN 128.11 (2005): 2732-2741.
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Dissociable cerebellar activity during spatial navigation and visual memory in bilateral vestibular failure.
Jandl NM, Sprenger A, Wojak JF, Gottlich M, Munte TF, Kramer UM, Helmchen C., Neuroscience 305(), 2015
PMID: 26255675
Acute Unilateral Vestibular Failure Does Not Cause Spatial Hemineglect.
Conrad J, Habs M, Brandt T, Dieterich M., PLoS ONE 10(8), 2015
PMID: 26247469
Self-motion direction discrimination in the visually impaired.
Moser I, Grabherr L, Hartmann M, Mast FW., Exp Brain Res 233(11), 2015
PMID: 26223579
Widespread vestibular activation of the rodent cortex.
Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW., J. Neurosci. 35(15), 2015
PMID: 25878265
Decreased postural control in adolescents born with extremely low birth weight.
Petersen H, Tulinius AT, Georgsdottir I, Einarsson EJ, Patel M, Haraldsson A, Fransson PA., Exp Brain Res 233(5), 2015
PMID: 25772673
Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis.
Kirste I, Nicola Z, Kronenberg G, Walker TL, Liu RC, Kempermann G., Brain Struct Funct 220(2), 2015
PMID: 24292324
Long-term effects from bacterial meningitis in childhood and adolescence on postural control.
Petersen H, Patel M, Ingason EF, Einarsson EJ, Haraldsson A, Fransson PA., PLoS ONE 9(11), 2014
PMID: 25405756
[Assessment of driving in patients with vertigo and dizziness].
von Brevern M, von Stuckrad-Barre S, Fetter M., Nervenarzt 85(7), 2014
PMID: 24906537
Vestibular loss and balance training cause similar changes in human cerebral white matter fractional anisotropy.
Hummel N, Hufner K, Stephan T, Linn J, Kremmyda O, Brandt T, Flanagin VL., PLoS ONE 9(4), 2014
PMID: 24776524
Unilateral vestibular loss impairs external space representation.
Borel L, Redon-Zouiteni C, Cauvin P, Dumitrescu M, Deveze A, Magnan J, Peruch P., PLoS ONE 9(2), 2014
PMID: 24523916
Galvanic vestibular stimulation impairs cell proliferation and neurogenesis in the rat hippocampus but not spatial memory.
Zheng Y, Geddes L, Sato G, Stiles L, Darlington CL, Smith PF., Hippocampus 24(5), 2014
PMID: 24449222
Changes in resting-state fMRI in vestibular neuritis.
Helmchen C, Ye Z, Sprenger A, Munte TF., Brain Struct Funct 219(6), 2014
PMID: 23881293
Inappropriate treatments for patients with cognitive decline.
Robles Bayon A, Gude Sampedro F., Neurologia 29(9), 2014
PMID: 23062764
Memory and self-neuroscientific landscapes.
Markowitsch HJ., ISRN Neurosci 2013(), 2013
PMID: 24967303
Vestibular activity and cognitive development in children: perspectives.
Wiener-Vacher SR, Hamilton DA, Wiener SI., Front Integr Neurosci 7(), 2013
PMID: 24376403
[Cardinal symptom vertigo from the neurologist's perspective].
Strupp M, Muth C, Bottcher N, Bayer O, Teufel J, Feil K, Bremova T, Kremmyda O, Fischer CS., HNO 61(9), 2013
PMID: 23979117
"Right Door," wrong floor: a canine deficiency in navigation.
Brandt T, Dieterich M., Hippocampus 23(4), 2013
PMID: 23355406
[Vertigo and dizziness: the neurologist's perspective].
Strupp M., Ophthalmologe 110(1), 2013
PMID: 23288313
Ego-rotation and object-rotation in major depressive disorder.
Chen J, Yang L, Ma W, Wu X, Zhang Y, Wei D, Liu G, Deng Z, Hua Z, Jia T., Psychiatry Res 209(1), 2013
PMID: 23218895
Perceptual and motor inhibition in individuals with vestibular disorders.
Mohammad MT, Whitney SL, Sparto PJ, Jennings JR, Furman JM., J Neurol Phys Ther 34(2), 2010
PMID: 20588092

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