Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56

Perlova O, Gerth K, Kaiser O, Hans A, Muller R (2006)
JOURNAL OF BIOTECHNOLOGY 121(2): 174-191.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Myxobacteria belonging to the genus Sorangium are known to produce a variety of biologically active secondary metabolites. Chivosazol is a macrocyclic antibiotic active against yeast, filamentous fungi and especially against mammalian cells. The compound specifically destroys the actin skeleton of eucaryotic cells and does not show activity against bacteria. Chivosazol contains an oxazole ring and a glycosidically bound 6-deoxyglucose (except for chivosazol F). In this paper we describe the biosynthetic gene cluster that directs chivosazol biosynthesis in the model strain Sorangium cellulosum So ce56. This biosynthetic gene cluster spans 92 kbp on the chromosome and contains four polyketide synthase genes and one hybrid polyketide synthase/nonribosomal peptide synthetase gene. An additional gene encoding a protein with similarity to different methyltransferases and presumably involved in post-polyketide modification was identified downstream of the core biosynthetic gene cluster. The chivosazol biosynthetic gene locus belongs to the recently identified and rapidly growing class of trans-acyltransferase polyketide synthases, which do not contain acyltransferase domains integrated into the multimodular megasynthetases. (c) 2005 Elsevier B.V. All rights reserved.
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JOURNAL OF BIOTECHNOLOGY
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121
Zeitschriftennummer
2
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174-191
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Perlova O, Gerth K, Kaiser O, Hans A, Muller R. Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY. 2006;121(2):174-191.
Perlova, O., Gerth, K., Kaiser, O., Hans, A., & Muller, R. (2006). Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY, 121(2), 174-191. doi:10.1016/j.jbiotec.2005.10.011
Perlova, O., Gerth, K., Kaiser, O., Hans, A., and Muller, R. (2006). Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY 121, 174-191.
Perlova, O., et al., 2006. Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY, 121(2), p 174-191.
O. Perlova, et al., “Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56”, JOURNAL OF BIOTECHNOLOGY, vol. 121, 2006, pp. 174-191.
Perlova, O., Gerth, K., Kaiser, O., Hans, A., Muller, R.: Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56. JOURNAL OF BIOTECHNOLOGY. 121, 174-191 (2006).
Perlova, O, Gerth, K, Kaiser, O, Hans, A, and Muller, R. “Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56”. JOURNAL OF BIOTECHNOLOGY 121.2 (2006): 174-191.

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Analysis of myxobacterial secondary metabolism goes molecular.
Bode HB, Müller R., J Ind Microbiol Biotechnol 33(7), 2006
PMID: 16491362
Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5.
Rachid S, Krug D, Kunze B, Kochems I, Scharfe M, Zabriskie TM, Blöcker H, Müller R., Chem Biol 13(6), 2006
PMID: 16793524

71 References

Daten bereitgestellt von Europe PubMed Central.

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering.
Scrutton NS, Berry A, Perham RN., Nature 343(6253), 1990
PMID: 2296288
New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.
Silakowski B, Schairer HU, Ehret H, Kunze B, Weinig S, Nordsiek G, Brandt P, Blocker H, Hofle G, Beyer S, Muller R., J. Biol. Chem. 274(52), 1999
PMID: 10601310
Plasmid vectors for the genetic analysis and manipulation of rhizobia and other gram-negative bacteria
Simon, Meth. Enzymol. 118(), 1986
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases.
Stachelhaus T, Mootz HD, Marahiel MA., Chem. Biol. 6(8), 1999
PMID: 10421756
Polyketide biosynthesis: a millennium review.
Staunton J, Weissman KJ., Nat Prod Rep 18(4), 2001
PMID: 11548049
Elucidating the mechanism of cis double bond formation in epothilone biosynthesis.
Tang L, Ward S, Chung L, Carney JR, Li Y, Reid R, Katz L., J. Am. Chem. Soc. 126(1), 2004
PMID: 14709052
Post-translational modification of polyketide and nonribosomal peptide synthases.
Walsh CT, Gehring AM, Weinreb PH, Quadri LE, Flugel RS., Curr Opin Chem Biol 1(3), 1997
PMID: 9667867
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines.
Walsh CT, Chen H, Keating TA, Hubbard BK, Losey HC, Luo L, Marshall CG, Miller DA, Patel HM., Curr Opin Chem Biol 5(5), 2001
PMID: 11578925
Origin of starter units for erythromycin biosynthesis.
Weissman KJ, Bycroft M, Staunton J, Leadlay PF., Biochemistry 37(31), 1998
PMID: 9692995
Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering.
Wenzel SC, Gross F, Zhang Y, Fu J, Stewart AF, Muller R., Chem. Biol. 12(3), 2005
PMID: 15797219
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity
Xue, Proc. Nat. Acad. Sci. U.S.A. 95(), 1998

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