Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds

Raible M, Evstigneev M, Bartels FW, Eckel R, Nguyen-Duong M, Merkel R, Ros R, Anselmetti D, Reimann P (2006)
Biophysical Journal 90(11): 3851-3864.

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We show that the standard theoretical framework in single-molecule force spectroscopy has to be extended to consistently describe the experimental findings. The basic amendment is to take into account heterogeneity of the chemical bonds via random variations of the force-dependent dissociation rates. This results in a very good agreement between theory and rupture data from several different experiments.
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Raible M, Evstigneev M, Bartels FW, et al. Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal. 2006;90(11):3851-3864.
Raible, M., Evstigneev, M., Bartels, F. W., Eckel, R., Nguyen-Duong, M., Merkel, R., Ros, R., et al. (2006). Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal, 90(11), 3851-3864. doi:10.1529/biophysj.105.077099
Raible, M., Evstigneev, M., Bartels, F. W., Eckel, R., Nguyen-Duong, M., Merkel, R., Ros, R., Anselmetti, D., and Reimann, P. (2006). Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal 90, 3851-3864.
Raible, M., et al., 2006. Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal, 90(11), p 3851-3864.
M. Raible, et al., “Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds”, Biophysical Journal, vol. 90, 2006, pp. 3851-3864.
Raible, M., Evstigneev, M., Bartels, F.W., Eckel, R., Nguyen-Duong, M., Merkel, R., Ros, R., Anselmetti, D., Reimann, P.: Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal. 90, 3851-3864 (2006).
Raible, M., Evstigneev, Mykhaylo, Bartels, Frank Wilco, Eckel, Rainer, Nguyen-Duong, M., Merkel, R., Ros, Robert, Anselmetti, Dario, and Reimann, Peter. “Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds”. Biophysical Journal 90.11 (2006): 3851-3864.
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Anselmetti D, Hansmeier N, Kalinowski J, Martini J, Merkle T, Palmisano R, Ros R, Schmied K, Sischka A, Toensing K., Anal Bioanal Chem 387(1), 2007
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What is the biological relevance of the specific bond properties revealed by single-molecule studies?
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Optimal evaluation of single-molecule force spectroscopy experiments.
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32 References

Data provided by Europe PubMed Central.

Effects of intermediate bound states in dynamic force spectroscopy.
Derenyi I, Bartolo D, Ajdari A., Biophys. J. 86(3), 2004
PMID: 14990459

AUTHOR UNKNOWN, 2002
A quantitative assessment of heterogeneity for surface-immobilized proteins.
Vijayendran RA, Leckband DE., Anal. Chem. 73(3), 2001
PMID: 11217749

AUTHOR UNKNOWN, 1999

AUTHOR UNKNOWN, 1999

AUTHOR UNKNOWN, 2003
LexA-DNA bond strength by single molecule force spectroscopy.
Kuhner F, Costa LT, Bisch PM, Thalhammer S, Heckl WM, Gaub HE., Biophys. J. 87(4), 2004
PMID: 15454462

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