Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds

Raible M, Evstigneev M, Bartels FW, Eckel R, Nguyen-Duong M, Merkel R, Ros R, Anselmetti D, Reimann P (2006)
Biophysical Journal 90(11): 3851-3864.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ;
Abstract
We show that the standard theoretical framework in single-molecule force spectroscopy has to be extended to consistently describe the experimental findings. The basic amendment is to take into account heterogeneity of the chemical bonds via random variations of the force-dependent dissociation rates. This results in a very good agreement between theory and rupture data from several different experiments.
Publishing Year
ISSN
PUB-ID

Cite this

Raible M, Evstigneev M, Bartels FW, et al. Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal. 2006;90(11):3851-3864.
Raible, M., Evstigneev, M., Bartels, F. W., Eckel, R., Nguyen-Duong, M., Merkel, R., Ros, R., et al. (2006). Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal, 90(11), 3851-3864. doi:10.1529/biophysj.105.077099
Raible, M., Evstigneev, M., Bartels, F. W., Eckel, R., Nguyen-Duong, M., Merkel, R., Ros, R., Anselmetti, D., and Reimann, P. (2006). Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal 90, 3851-3864.
Raible, M., et al., 2006. Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal, 90(11), p 3851-3864.
M. Raible, et al., “Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds”, Biophysical Journal, vol. 90, 2006, pp. 3851-3864.
Raible, M., Evstigneev, M., Bartels, F.W., Eckel, R., Nguyen-Duong, M., Merkel, R., Ros, R., Anselmetti, D., Reimann, P.: Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds. Biophysical Journal. 90, 3851-3864 (2006).
Raible, M., Evstigneev, Mykhaylo, Bartels, Frank Wilco, Eckel, Rainer, Nguyen-Duong, M., Merkel, R., Ros, Robert, Anselmetti, Dario, and Reimann, Peter. “Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds”. Biophysical Journal 90.11 (2006): 3851-3864.
This data publication is cited in the following publications:
This publication cites the following data publications:

33 Citations in Europe PMC

Data provided by Europe PubMed Central.

Two barriers or not? Dynamic force spectroscopy on the integrin α7β1 invasin complex.
Boye K, Ligezowska A, Eble JA, Hoffmann B, Klosgen B, Merkel R., Biophys. J. 105(12), 2013
PMID: 24359749
Hidden multiple bond effects in dynamic force spectroscopy.
Getfert S, Reimann P., Biophys. J. 102(5), 2012
PMID: 22404941
Observing the osmophobic effect in action at the single molecule level.
Aioanei D, Tessari I, Bubacco L, Samori B, Brucale M., Proteins 79(7), 2011
PMID: 21557325
Force-induced lysozyme--HyHEL5 antibody dissociation and its analysis by means of a cooperative binding model.
Katletz S, Stroh C, Rankl C, Titulaer UM, Hinterdorfer P., Biophys. J. 99(1), 2010
PMID: 20655861
Maximum likelihood estimation of protein kinetic parameters under weak assumptions from unfolding force spectroscopy experiments.
Aioanei D, Samori B, Brucale M., Phys Rev E Stat Nonlin Soft Matter Phys 80(6 Pt 1), 2009
PMID: 20365199
A structural, kinetic model of soft tissue thermomechanics.
Stylianopoulos T, Aksan A, Barocas VH., Biophys. J. 94(3), 2008
PMID: 17890379

32 References

Data provided by Europe PubMed Central.

Effects of intermediate bound states in dynamic force spectroscopy.
Derenyi I, Bartolo D, Ajdari A., Biophys. J. 86(3), 2004
PMID: 14990459

AUTHOR UNKNOWN, 2002
A quantitative assessment of heterogeneity for surface-immobilized proteins.
Vijayendran RA, Leckband DE., Anal. Chem. 73(3), 2001
PMID: 11217749

AUTHOR UNKNOWN, 1999

AUTHOR UNKNOWN, 1999

AUTHOR UNKNOWN, 2003
LexA-DNA bond strength by single molecule force spectroscopy.
Kuhner F, Costa LT, Bisch PM, Thalhammer S, Heckl WM, Gaub HE., Biophys. J. 87(4), 2004
PMID: 15454462

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 16513778
PubMed | Europe PMC

Search this title in

Google Scholar