Bioanalysis in structured microfluidic systems

Ros A, Hellmich W, Regtmeier J, Duong TT, Anselmetti D (2006)
Electrophoresis 27(13): 2651-2658.

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Microfluiclic and lab-on-a-chip devices have attracted widespread interest in separation sciences and bioanalysis. Recent designs in microfluidic devices extend common separation concepts by exploiting new phenomena for molecular dynamics on a length scale of 10 mu m and below, giving rise to novel manipulation tools and nonintuitive phenomena for microseparations. Here, we focus on three very recent developments for bioseparations based on tailored microfluidic systems: Single cell navigation, trapping and steering with subsequent on-chip lysis, protein separation and LIF detection (Section 3.1), then we report dielectrophoretic trapping and separation of large DNA fragments in structured microfluidic devices (Section 3.2). Finally, a paradoxial migration phenomenon based on thermal fluctuations, periodically arranged microchannels and a biased alternating current electric field is presented in Section 3.3.
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Ros A, Hellmich W, Regtmeier J, Duong TT, Anselmetti D. Bioanalysis in structured microfluidic systems. Electrophoresis. 2006;27(13):2651-2658.
Ros, A., Hellmich, W., Regtmeier, J., Duong, T. T., & Anselmetti, D. (2006). Bioanalysis in structured microfluidic systems. Electrophoresis, 27(13), 2651-2658. doi:10.1002/elps.200500923
Ros, A., Hellmich, W., Regtmeier, J., Duong, T. T., and Anselmetti, D. (2006). Bioanalysis in structured microfluidic systems. Electrophoresis 27, 2651-2658.
Ros, A., et al., 2006. Bioanalysis in structured microfluidic systems. Electrophoresis, 27(13), p 2651-2658.
A. Ros, et al., “Bioanalysis in structured microfluidic systems”, Electrophoresis, vol. 27, 2006, pp. 2651-2658.
Ros, A., Hellmich, W., Regtmeier, J., Duong, T.T., Anselmetti, D.: Bioanalysis in structured microfluidic systems. Electrophoresis. 27, 2651-2658 (2006).
Ros, Alexandra, Hellmich, Wibke, Regtmeier, Jan, Duong, Thanh Tu, and Anselmetti, Dario. “Bioanalysis in structured microfluidic systems”. Electrophoresis 27.13 (2006): 2651-2658.
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27 Citations in Europe PMC

Data provided by Europe PubMed Central.

Analysis of subcellular surface structure, function and dynamics.
Anselmetti D, Hansmeier N, Kalinowski J, Martini J, Merkle T, Palmisano R, Ros R, Schmied K, Sischka A, Toensing K., Anal Bioanal Chem 387(1), 2007
PMID: 17082883
Analysis of single mammalian cells on-chip.
Sims CE, Allbritton NL., Lab Chip 7(4), 2007
PMID: 17389958

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