Coarse-grained lattice model for molecular recognition

Behringer H, Degenhard A, Schmid F (2006)
Physical Review Letters 97(12): 128101.

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We present a simple model which allows us to investigate the equilibrium aspects of molecular recognition between rigid biomolecules on a generic level. Using a two-stage approach, which consists of a design and a testing step, the role of cooperativity and of varying bond strength in molecular recognition is investigated. Cooperativity is found to enhance selectivity. In complexes which require a high binding flexibility, a small number of strong bonds seems to be favored compared to a situation with many but weak bonds.
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Behringer H, Degenhard A, Schmid F. Coarse-grained lattice model for molecular recognition. Physical Review Letters. 2006;97(12): 128101.
Behringer, H., Degenhard, A., & Schmid, F. (2006). Coarse-grained lattice model for molecular recognition. Physical Review Letters, 97(12), 128101. doi:10.1103/PhysRevLett.97.128101
Behringer, H., Degenhard, A., and Schmid, F. (2006). Coarse-grained lattice model for molecular recognition. Physical Review Letters 97:128101.
Behringer, H., Degenhard, A., & Schmid, F., 2006. Coarse-grained lattice model for molecular recognition. Physical Review Letters, 97(12): 128101.
H. Behringer, A. Degenhard, and F. Schmid, “Coarse-grained lattice model for molecular recognition”, Physical Review Letters, vol. 97, 2006, : 128101.
Behringer, H., Degenhard, A., Schmid, F.: Coarse-grained lattice model for molecular recognition. Physical Review Letters. 97, : 128101 (2006).
Behringer, Hans, Degenhard, Andreas, and Schmid, Friederike. “Coarse-grained lattice model for molecular recognition”. Physical Review Letters 97.12 (2006): 128101.
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10 Citations in Europe PMC

Data provided by Europe PubMed Central.

A schematic model for molecular affinity and binding with Ising variables.
Thalmann F., Eur Phys J E Soft Matter 31(4), 2010
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Dry and wet interfaces: influence of solvent particles on molecular recognition.
Taktikos J, Behringer H., Phys Rev E Stat Nonlin Soft Matter Phys 79(4 Pt 1), 2009
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Influence of correlations on molecular recognition.
Behringer H, Schmid F., Phys Rev E Stat Nonlin Soft Matter Phys 78(3 Pt 1), 2008
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Coarse-grained lattice model for investigating the role of cooperativity in molecular recognition.
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Developing and analyzing idealized models for molecular recognition.
Behringer H, Bogner T, Polotsky A, Degenhard A, Schmid F., J. Biotechnol. 129(2), 2007
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