bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection

Kaminaka H, Naeke C, Epple P, Dittgen J, Schuetze K, Chaban C, Holt BF, III, Merkle T, Schaefer E, Harter K, Dangl JL (2006)
The EMBO JOURNAL 25(18): 4400-4411.

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Journal Article | Original Article | Published | English

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Fakultät für Biologie > Genomforschung
Centrum für Biotechnologie
Abstract
Plants use sophisticated strategies to balance responses to oxidative stress. Programmed cell death, including the hypersensitive response (HR) associated with successful pathogen recognition, is one cellular response regulated by reactive oxygen in various cellular contexts. The Arabidopsis basic leucine zipper (bZIP) transcription factor AtbZIP10 shuttles between the nucleus and the cytoplasm and binds consensus G- and C-box DNA sequences. Surprisingly, AtbZIP10 can be retained outside the nucleus by LSD1, a protein that protects Arabidopsis cells from death in the face of oxidative stress signals. We demonstrate that AtbZIP10 is a positive mediator of the uncontrolled cell death observed in lsd1 mutants. AtbZIP10 and LSD1 act antagonistically in both pathogen-induced HR and basal defense responses. LSD1 likely functions as a cellular hub, where its interaction with AtbZIP10 and additional, as yet unidentified, proteins contributes significantly to plant oxidative stress responses.
Keywords
basal defense ; nuclear shuttling ; hypersensitive cell death ; reactive oxygen ; Hyaloperonospora parasitica
Publishing Year
2006
ISSN
0261-4189
eISSN
1460-2075
PUB-ID

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Kaminaka H, Naeke C, Epple P, et al. bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection. The EMBO JOURNAL. 2006;25(18):4400-4411.
Kaminaka, H., Naeke, C., Epple, P., Dittgen, J., Schuetze, K., Chaban, C., Holt, B. F. , I. I. I., et al. (2006). bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection. The EMBO JOURNAL, 25(18), 4400-4411. doi:10.1038/sj.emboj.7601312
Kaminaka, H., Naeke, C., Epple, P., Dittgen, J., Schuetze, K., Chaban, C., Holt, B. F. , I. I. I., Merkle, T., Schaefer, E., Harter, K., et al. (2006). bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection. The EMBO JOURNAL 25, 4400-4411.
Kaminaka, H., et al., 2006. bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection. The EMBO JOURNAL, 25(18), p 4400-4411.
H. Kaminaka, et al., “bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection”, The EMBO JOURNAL, vol. 25, 2006, pp. 4400-4411.
Kaminaka, H., Naeke, C., Epple, P., Dittgen, J., Schuetze, K., Chaban, C., Holt, B.F., I.I.I., Merkle, T., Schaefer, E., Harter, K., Dangl, J.L.: bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection. The EMBO JOURNAL. 25, 4400-4411 (2006).
Kaminaka, Hironori, Naeke, Christian, Epple, Petra, Dittgen, Jan, Schuetze, Katia, Chaban, Christina, Holt, Ben F., III, Merkle, Thomas, Schaefer, Eberhard, Harter, Klaus, and Dangl, Jeffery L. “bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection”. The EMBO JOURNAL 25.18 (2006): 4400-4411.
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