Carbohydrate mimics promote functional recovery after peripheral nerve repair

Simova O, Irintchev A, Mehanna A, Liu J, Dihne M, Baechle D, Sewald N, Loers G, Schachner M (2006)
ANNALS OF NEUROLOGY 60(4): 430-437.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ; ; ; ;
Abstract / Bemerkung
Objective: The outcome of peripheral nerve repair is often unsatisfactory, and efficient therapies are not available. We tested the therapeutic potential of functional mimics of the human natural killer cell glycan (3-sulfoglucuronyl beta 1-3 galactoside) (HNK-1) epitope, a carbohydrate indicated to favor specificity of motor reinnervation in mice. Methods: We applied a linear HNK-1 mimic peptide, scrambled peptide, or vehicle substances in polyethylene cuffs used to reconstruct the severed femoral nerves of adult mice. We used video-based motion analysis and morphological and tracing techniques to monitor the outcome of nerve repair. Results: After glycomimetic application, quadriceps muscle function recovered to 93% of normal within 3 months. Restoration of function was less complete (71-76%) in control groups. Better functional recovery was associated with larger motoneuron somata, better axonal myelination in the quadriceps nerve, and enhanced precision of target reinnervation. Lesion-induced death of motoneurons was reduced by 20 to 25%. The glycomimetic enhanced survival and neurite outgrowth of both mouse and human motoneurons in vitro by 30 to 75%. Application of a novel cyclic glycomimetic also enhanced functional recovery in vivo. Interpretation: The improved outcome of nerve repair after glycomimetic application may be attributed to neurotrophic effects. Our results hold promise for therapeutic use in humans.
Erscheinungsjahr
Zeitschriftentitel
ANNALS OF NEUROLOGY
Band
60
Zeitschriftennummer
4
Seite
430-437
ISSN
PUB-ID

Zitieren

Simova O, Irintchev A, Mehanna A, et al. Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY. 2006;60(4):430-437.
Simova, O., Irintchev, A., Mehanna, A., Liu, J., Dihne, M., Baechle, D., Sewald, N., et al. (2006). Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY, 60(4), 430-437. doi:10.1002/ana.20948
Simova, O., Irintchev, A., Mehanna, A., Liu, J., Dihne, M., Baechle, D., Sewald, N., Loers, G., and Schachner, M. (2006). Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY 60, 430-437.
Simova, O., et al., 2006. Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY, 60(4), p 430-437.
O. Simova, et al., “Carbohydrate mimics promote functional recovery after peripheral nerve repair”, ANNALS OF NEUROLOGY, vol. 60, 2006, pp. 430-437.
Simova, O., Irintchev, A., Mehanna, A., Liu, J., Dihne, M., Baechle, D., Sewald, N., Loers, G., Schachner, M.: Carbohydrate mimics promote functional recovery after peripheral nerve repair. ANNALS OF NEUROLOGY. 60, 430-437 (2006).
Simova, Olga, Irintchev, Andrey, Mehanna, Ali, Liu, Jiankun, Dihne, Marcel, Baechle, Dirk, Sewald, Norbert, Loers, Gabriele, and Schachner, Melitta. “Carbohydrate mimics promote functional recovery after peripheral nerve repair”. ANNALS OF NEUROLOGY 60.4 (2006): 430-437.

39 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Positively and negatively modulating cell adhesion to type I collagen via peptide grafting.
Monteiro GA, Fernandes AV, Sundararaghavan HG, Shreiber DI., Tissue Eng Part A 17(13-14), 2011
PMID: 19196133
Polysialic acid glycomimetic promotes functional recovery and plasticity after spinal cord injury in mice.
Mehanna A, Jakovcevski I, Acar A, Xiao M, Loers G, Rougon G, Irintchev A, Schachner M., Mol Ther 18(1), 2010
PMID: 19826404
Functional effects of local thyroid hormone administration after sciatic nerve injury in rats.
Papakostas I, Mourouzis I, Mourouzis K, Macheras G, Boviatsis E, Pantos C., Microsurgery 29(1), 2009
PMID: 18942650
Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice.
Mehanna A, Mishra B, Kurschat N, Schulze C, Bian S, Loers G, Irintchev A, Schachner M., Brain 132(pt 6), 2009
PMID: 19454531
Chemical communication between regenerating motor axons and Schwann cells in the growth pathway.
Vrbova G, Mehra N, Shanmuganathan H, Tyreman N, Schachner M, Gordon T., Eur J Neurosci 30(3), 2009
PMID: 19656172
Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury.
Gordon T, Chan KM, Sulaiman OA, Udina E, Amirjani N, Brushart TM., Neurosurgery 65(4 suppl), 2009
PMID: 19927058
The impact of motor and sensory nerve architecture on nerve regeneration.
Moradzadeh A, Borschel GH, Luciano JP, Whitlock EL, Hayashi A, Hunter DA, Mackinnon SE., Exp Neurol 212(2), 2008
PMID: 18550053
Manual stimulation of the suprahyoid-sublingual region diminishes polynnervation of the motor endplates and improves recovery of function after hypoglossal nerve injury in rats.
Evgenieva E, Schweigert P, Guntinas-Lichius O, Pavlov S, Grosheva M, Angelova S, Streppel M, Irintchev A, Skouras E, Kuerten S, Sinis N, Dunlop S, Radeva V, Angelov DN., Neurorehabil Neural Repair 22(6), 2008
PMID: 18612142
Recognition molecules and neural repair.
Loers G, Schachner M., J Neurochem 101(4), 2007
PMID: 17254012
One hour electrical stimulation accelerates functional recovery after femoral nerve repair.
Ahlborn P, Schachner M, Irintchev A., Exp Neurol 208(1), 2007
PMID: 17919580
Differential expression of HNK-1 and p75(NTR) in adult canine Schwann cells and olfactory ensheathing cells in situ but not in vitro.
Bock P, Beineke A, Techangamsuwan S, Baumgärtner W, Wewetzer K., J Comp Neurol 505(5), 2007
PMID: 17924534

50 References

Daten bereitgestellt von Europe PubMed Central.

The facial nerve axotomy model.
Moran LB, Graeber MB., Brain Res. Brain Res. Rev. 44(2-3), 2004
PMID: 15003391
Glycans and neural cell interactions.
Kleene R, Schachner M., Nat. Rev. Neurosci. 5(3), 2004
PMID: 14976519
Displacement of synaptic terminals from regenerating motoneurons by microglial cells
Blinzinger, Zeitschrift für Zellforschung und Mikroskopische Anatomie 85(2), 1968
Altered expression of immune-related antigens by neuronophages does not improve neuronal survival after severe lesion of the facial nerve in rats.
Angelov DN, Krebs C, Walther M, Martinez-Portillo FJ, Gunkel A, Lay CH, Streppel M, Guntinas-Lichius O, Stennert E, Neiss WF., Glia 24(2), 1998
PMID: 9728762
Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1.
Kruse J, Mailhammer R, Wernecke H, Faissner A, Sommer I, Goridis C, Schachner M., Nature 311(5982), 1984
PMID: 6206400
Antagonism of RAGE suppresses peripheral nerve regeneration.
Rong LL, Trojaborg W, Qu W, Kostov K, Yan SD, Gooch C, Szabolcs M, Hays AP, Schmidt AM., FASEB J. 18(15), 2004
PMID: 15576484
RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways.
Rong LL, Yan SF, Wendt T, Hans D, Pachydaki S, Bucciarelli LG, Adebayo A, Qu W, Lu Y, Kostov K, Lalla E, Yan SD, Gooch C, Szabolcs M, Trojaborg W, Hays AP, Schmidt AM., FASEB J. 18(15), 2004
PMID: 15576485
Sulfoglycolipids bind to adhesive protein amphoterin (P30) in the nervous system.
Mohan PS, Laitinen J, Merenmies J, Rauvala H, Jungalwala FB., Biochem. Biophys. Res. Commun. 182(2), 1992
PMID: 1370890
Aberrant reinnervation.
Sumner AJ., Muscle Nerve 13(9), 1990
PMID: 2233866
Pathway sampling by regenerating peripheral axons.
Witzel C, Rohde C, Brushart TM., J. Comp. Neurol. 485(3), 2005
PMID: 15791642
HMGB1: guiding immunity from within.
Dumitriu IE, Baruah P, Manfredi AA, Bianchi ME, Rovere-Querini P., Trends Immunol. 26(7), 2005
PMID: 15978523
Specific expression of an HNK-1 carbohydrate epitope and NCAM on femoral nerve Schwann cells in mice.
Saito H, Nakao Y, Takayama S, Toyama Y, Asou H., Neurosci. Res. 53(3), 2005
PMID: 16171882
BDNF/TrkB signaling regulates HNK-1 carbohydrate expression in regenerating motor nerves and promotes functional recovery after peripheral nerve repair.
Eberhardt KA, Irintchev A, Al-Majed AA, Simova O, Brushart TM, Gordon T, Schachner M., Exp. Neurol. 198(2), 2006
PMID: 16460731
The L2/HNK-1 carbohydrate mediates adhesion of neural cells to laminin.
Hall H, Liu L, Schachner M, Schmitz B., Eur. J. Neurosci. 5(1), 1993
PMID: 8261088
Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules.
Holm J, Hillenbrand R, Steuber V, Bartsch U, Moos M, Lubbert H, Montag D, Schachner M., Eur. J. Neurosci. 8(8), 1996
PMID: 8921253

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 16958115
PubMed | Europe PMC

Suchen in

Google Scholar