Gender differences in germ-cell mutagenesis and genetic risk

Eichenlaub-Ritter U, Adler I-D, Carere A, Pacchierotti F (2007)
ENVIRONMENTAL RESEARCH 104(1): 22-36.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ;
Abstract
Current international classification systems for chemical mutagens are hazard-based rather than aimed at assessing risks quantitatively. In the past, germ-cell tests have been mainly performed with a limited number of somatic cell mutagens, and rarely under conditions aimed at comparing gender-specific differences in susceptibility to mutagen exposures. There are profound differences in the genetic constitution, and in hormonal, structural, and functional aspects of differentiation and control of gametogenesis between the sexes. A critical review of the literature suggests that these differences may have a profound impact on the relative susceptibility, stage of highest sensitivity and the relative risk for the genesis of gene mutation, as well as structural and numerical chromosomal aberrations in male and female germ cells. Transmission of germ-cell mutations to the offspring may also encounter gender-specific influences. Gender differences in susceptibility to chemically derived alterations in imprinting patterns may pose a threat for the health of the offspring and may also be transmitted to future generations. Recent reports on different genetic effects from high acute and from chronic low-dose exposures challenge the validity of conclusions drawn from standard methods of mutagenicity testing. In conclusion, research is urgently needed to identify genetic hazards for a larger range of chemical compounds, including those suspected to disturb proper chromosome segregation. Alterations in epigenetic programming and their health consequences will have to be investigated. More attention should be paid to gender-specific genetic effects. Finally, the database for germ-cell mutagens should be enlarged using molecular methodologies, and genetic epidemiology studies should be performed with these techniques to verify human genetic risk. (c) 2006 Elsevier Inc. All rights reserved.
Publishing Year
ISSN
PUB-ID

Cite this

Eichenlaub-Ritter U, Adler I-D, Carere A, Pacchierotti F. Gender differences in germ-cell mutagenesis and genetic risk. ENVIRONMENTAL RESEARCH. 2007;104(1):22-36.
Eichenlaub-Ritter, U., Adler, I. - D., Carere, A., & Pacchierotti, F. (2007). Gender differences in germ-cell mutagenesis and genetic risk. ENVIRONMENTAL RESEARCH, 104(1), 22-36.
Eichenlaub-Ritter, U., Adler, I. - D., Carere, A., and Pacchierotti, F. (2007). Gender differences in germ-cell mutagenesis and genetic risk. ENVIRONMENTAL RESEARCH 104, 22-36.
Eichenlaub-Ritter, U., et al., 2007. Gender differences in germ-cell mutagenesis and genetic risk. ENVIRONMENTAL RESEARCH, 104(1), p 22-36.
U. Eichenlaub-Ritter, et al., “Gender differences in germ-cell mutagenesis and genetic risk”, ENVIRONMENTAL RESEARCH, vol. 104, 2007, pp. 22-36.
Eichenlaub-Ritter, U., Adler, I.-D., Carere, A., Pacchierotti, F.: Gender differences in germ-cell mutagenesis and genetic risk. ENVIRONMENTAL RESEARCH. 104, 22-36 (2007).
Eichenlaub-Ritter, Ursula, Adler, Ilse-Dore, Carere, Angelo, and Pacchierotti, Francesca. “Gender differences in germ-cell mutagenesis and genetic risk”. ENVIRONMENTAL RESEARCH 104.1 (2007): 22-36.
This data publication is cited in the following publications:
This publication cites the following data publications:

5 Citations in Europe PMC

Data provided by Europe PubMed Central.

Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation.
Bunin GR, Felice MA, Davidson W, Friedman DL, Shields CL, Maidment A, O'Shea M, Nichols KE, Leahey A, Dunkel IJ, Jubran R, Rodriguez-Galindo C, Schmidt ML, Weinstein JL, Goldman S, Abramson DH, Wilson MW, Gallie BL, Chan HS, Shapiro M, Cnaan A, Ganguly A, Meadows AT., Int. J. Cancer 128(10), 2011
PMID: 20648557
Sex-gender research sensitivity and healthcare disparities.
Gochfeld M., J Womens Health (Larchmt) 19(2), 2010
PMID: 20113150
Sexual dimorphism in parental imprint ontogeny and contribution to embryonic development.
Bourc'his D, Proudhon C., Mol. Cell. Endocrinol. 282(1-2), 2008
PMID: 18178305
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U., Mutat. Res. 651(1-2), 2008
PMID: 18096427

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 17156773
PubMed | Europe PMC

Search this title in

Google Scholar