Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool

Schlüter A, Szczepanowski R, Pühler A, Top EM (2007)
FEMS MICROBIOLOGY REVIEWS 31(4): 449-477.

Journal Article | Published | English

No fulltext has been uploaded

Abstract
The dramatic spread of antibiotic resistance is a crisis in the treatment of infectious diseases that affect humans. Several studies suggest that wastewater treatment plants (WWTP) are reservoirs for diverse mobile antibiotic resistance elements. This review summarizes findings derived from genomic analysis of IncP-1 resistance plasmids isolated from WWTP bacteria. Plasmids that belong to the IncP-1 group are self-transmissible, and transfer to and replicate in a wide range of hosts. Their backbone functions are described with respect to their impact on vegetative replication, stable maintenance and inheritance, mobility and plasmid control. Accessory genetic modules, mainly representing mobile genetic elements, are integrated in-between functional plasmid backbone modules. These elements carry determinants conferring resistance to nearly all clinically relevant antimicrobial drug classes, to heavy metals, and quaternary ammonium compounds used as disinfectants. All plasmids analysed here contain integrons that potentially facilitate integration, exchange and dissemination of resistance gene cassettes. Comparative genomics of accessory modules located on plasmids from WWTP and corresponding modules previously identified in other bacterial genomes revealed that animal, human and plant pathogens and other bacteria isolated from different habitats share a common pool of resistance determinants.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Schlüter A, Szczepanowski R, Pühler A, Top EM. Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool. FEMS MICROBIOLOGY REVIEWS. 2007;31(4):449-477.
Schlüter, A., Szczepanowski, R., Pühler, A., & Top, E. M. (2007). Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool. FEMS MICROBIOLOGY REVIEWS, 31(4), 449-477.
Schlüter, A., Szczepanowski, R., Pühler, A., and Top, E. M. (2007). Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool. FEMS MICROBIOLOGY REVIEWS 31, 449-477.
Schlüter, A., et al., 2007. Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool. FEMS MICROBIOLOGY REVIEWS, 31(4), p 449-477.
A. Schlüter, et al., “Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool”, FEMS MICROBIOLOGY REVIEWS, vol. 31, 2007, pp. 449-477.
Schlüter, A., Szczepanowski, R., Pühler, A., Top, E.M.: Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool. FEMS MICROBIOLOGY REVIEWS. 31, 449-477 (2007).
Schlüter, Andreas, Szczepanowski, Rafael, Pühler, Alfred, and Top, Eva M. “Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool”. FEMS MICROBIOLOGY REVIEWS 31.4 (2007): 449-477.
This data publication is cited in the following publications:
This publication cites the following data publications:

118 Citations in Europe PMC

Data provided by Europe PubMed Central.

Phylogenetic Distribution of CRISPR-Cas Systems in Antibiotic-Resistant Pseudomonas aeruginosa.
van Belkum A, Soriaga LB, LaFave MC, Akella S, Veyrieras JB, Barbu EM, Shortridge D, Blanc B, Hannum G, Zambardi G, Miller K, Enright MC, Mugnier N, Brami D, Schicklin S, Felderman M, Schwartz AS, Richardson TH, Peterson TC, Hubby B, Cady KC., MBio 6(6), 2015
PMID: 26604259
Coliform bacteria isolated from recreational lakes carry class 1 and class 2 integrons and virulence-associated genes.
Koczura R, Krysiak N, Taraszewska A, Mokracka J., J. Appl. Microbiol. 119(2), 2015
PMID: 25963437
Characterization of a collection of plasmid-containing bacteria isolated from an on-farm biopurification system used for pesticide removal.
Martini MC, Albicoro FJ, Nour E, Schluter A, van Elsas JD, Springael D, Smalla K, Pistorio M, Lagares A, Del Papa MF., Plasmid 80(), 2015
PMID: 25957823
Effects of 100 years wastewater irrigation on resistance genes, class 1 integrons and IncP-1 plasmids in Mexican soil.
Jechalke S, Broszat M, Lang F, Siebe C, Smalla K, Grohmann E., Front Microbiol 6(), 2015
PMID: 25784901
The broad-host-range plasmid pSFA231 isolated from petroleum-contaminated sediment represents a new member of the PromA plasmid family.
Li X, Top EM, Wang Y, Brown CJ, Yao F, Yang S, Jiang Y, Li H., Front Microbiol 5(), 2014
PMID: 25628616
Horizontal transfer of antibiotic resistance genes in a membrane bioreactor.
Yang D, Wang J, Qiu Z, Jin M, Shen Z, Chen Z, Wang X, Zhang B, Li JW., J. Biotechnol. 167(4), 2013
PMID: 23942379
Transformation of N-phenylpiperazine by mixed cultures from a municipal wastewater treatment plant.
Jung CM, Heinze TM, Deck J, Strakosha R, Sutherland JB., Appl. Environ. Microbiol. 74(19), 2008
PMID: 18676696

238 References

Data provided by Europe PubMed Central.

Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant.
Szczepanowski R, Krahn I, Bohn N, Puhler A, Schluter A., Antimicrob. Agents Chemother. 51(2), 2007
PMID: 17101677
Impact of conjugal transfer on the stability of IncP-1 plasmid pKJK5 in bacterial populations.
Bahl MI, Hansen LH, Sorensen SJ., FEMS Microbiol. Lett. 266(2), 2007
PMID: 17132149
Plasmid pBP136 from Bordetella pertussis represents an ancestral form of IncP-1beta plasmids without accessory mobile elements.
Kamachi K, Sota M, Tamai Y, Nagata N, Konda T, Inoue T, Top EM, Arakawa Y., Microbiology (Reading, Engl.) 152(Pt 12), 2006
PMID: 17159199
Complete sequence of pSC101.
Bernardi A, Bernardi F., Nucleic Acids Res. 12(24), 1984
PMID: 6096829
Stability of a promiscuous plasmid in different hosts: no guarantee for a long-term relationship.
De Gelder L, Ponciano JM, Joyce P, Top EM., Microbiology (Reading, Engl.) 153(Pt 2), 2007
PMID: 17259616
Sequence of plasmid pBS228 and reconstruction of the IncP-1alpha phylogeny.
Haines AS, Jones K, Batt SM, Kosheleva IA, Thomas CM., Plasmid 58(1), 2007
PMID: 17320955
Structural and dynamic properties of bacterial type IV secretion systems (review).
Christie PJ, Cascales E., Mol. Membr. Biol. 22(1-2), 2005
PMID: 16092524
Chloramphenicol: a review.
Balbi HJ., Pediatr Rev 25(8), 2004
PMID: 15286274
Retrotransfer of IncP1-like plasmids from aquatic bacteria
Hill, Letters in Applied Microbiology 20(5), 1995

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 17553065
PubMed | Europe PMC

Search this title in

Google Scholar