Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum

Lenta BN, Devkota KP, Ngouela S, Boyom FF, Naz Q, Choudhary ML, Tsamo E, Rosenthal PJ, Sewald N (2008)
CHEMICAL & PHARMACEUTICAL BULLETIN 56(2): 222-226.

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Abstract
Glaberianthrone (1), a new bianthrone was isolated from the hexane extract of the stem bark of Psorospermum glaberrimum together with thirteen known compounds: 3-geranyloxyemodin anthrone (2), friedelan-3-one (3), 3-prenyloxyemodin anthrone (4), 3-geranyloxyemodin (5), 3-prenyloxyemodin (6), friedelan-3-ol (7), acetylvismione D (8), betulinic acid (9), 2-geranylemodin (10), bianthrone A2b (11), bianthrone 1a (12), emodin (13) and 2-prenylemodin (14). The structures of the isolated compounds were established by means of spectroscopic methods. The extracts and the isolated compounds were tested in vitro for their anti-plasmodial activity against Plasmodium falciparum (chloroquine resistant strain W2) and for their acetyl- and butyryleholinesterase inhibitory properties. The n-hexane extract showed good anti-plasmodial activity against P falciparum W2 strain, with IC50 of 0.87 mu g/ml. It also exhibited 65.5% and 98.2% of acetyl- and butyrylcholinesterase inhibition at 0.2 mg/ml, respectively. Compounds 2 and 8 showed the best potencies against P falciparum W2 strain with IC50 of 1.68 mu M and 0.12 mu M, (0.66 mu g/ml and 0.054 mu g/ml) respectively. All tested compounds showed good butyrylcholinesterase inhibition activities with compound 12 displaying the best potency (IC50 9.25 +/- 0.25 mu M). All the tested compounds showed weak inhibitory activity against acetylcholinesterase.
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Lenta BN, Devkota KP, Ngouela S, et al. Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. CHEMICAL & PHARMACEUTICAL BULLETIN. 2008;56(2):222-226.
Lenta, B. N., Devkota, K. P., Ngouela, S., Boyom, F. F., Naz, Q., Choudhary, M. L., Tsamo, E., et al. (2008). Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. CHEMICAL & PHARMACEUTICAL BULLETIN, 56(2), 222-226.
Lenta, B. N., Devkota, K. P., Ngouela, S., Boyom, F. F., Naz, Q., Choudhary, M. L., Tsamo, E., Rosenthal, P. J., and Sewald, N. (2008). Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. CHEMICAL & PHARMACEUTICAL BULLETIN 56, 222-226.
Lenta, B.N., et al., 2008. Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. CHEMICAL & PHARMACEUTICAL BULLETIN, 56(2), p 222-226.
B.N. Lenta, et al., “Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum”, CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 56, 2008, pp. 222-226.
Lenta, B.N., Devkota, K.P., Ngouela, S., Boyom, F.F., Naz, Q., Choudhary, M.L., Tsamo, E., Rosenthal, P.J., Sewald, N.: Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. CHEMICAL & PHARMACEUTICAL BULLETIN. 56, 222-226 (2008).
Lenta, Bruno Ndjakou, Devkota, Krishna Prasad, Ngouela, Silvere, Boyom, Fabrice Fekam, Naz, Quamar, Choudhary, Muhammad Lqbal, Tsamo, Etienne, Rosenthal, Philip Jon, and Sewald, Norbert. “Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum”. CHEMICAL & PHARMACEUTICAL BULLETIN 56.2 (2008): 222-226.
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