Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis

Schoen C, Blom J, Claus H, Schramm-Glueck A, Brandt P, Mueller T, Goesmann A, Joseph B, Konietzny S, Kurzai O, Schmitt C, et al. (2008)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(9): 3473-3478.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ; ; ;
All
Abstract
Neisseria meningitidis is a leading cause of infectious childhood mortality worldwide. Most research efforts have hitherto focused on disease isolates belonging to only a few hypervirulent clonal lineages. However, up to 10% of the healthy human population is temporarily colonized by genetically diverse strains mostly with little or no pathogenic potential. Currently, little is known about the biology of carriage strains and their evolutionary relationship with disease isolates. The expression of a polysaccharide capsule is the only trait that has been convincingly linked to the pathogenic potential of N. meningitidis. To gain insight into the evolution of virulence traits in this species, whole-genome sequences of three meningococcal carriage isolates were obtained. Gene content comparisons with the available genome sequences from three disease isolates indicate that there is no core pathogenome in N. meningitidis. A comparison of the chromosome structure suggests that a filamentous prophage has mediated large chromosomal rearrangements and the translocation of some candidate virulence genes. Interspecific comparison of the available Neisseria genome sequences and dot blot hybridizations further indicate that the insertion sequence IS1655 is restricted only to N. meningitidis; its low sequence diversity is an indicator of an evolutionarily recent population bottleneck. A genome-based phylogenetic reconstruction provides evidence that N. meningitidis has emerged as an unencapsulated human commensal from a common ancestor with Neisseria gonorrhoeae and Neisseria lactamica and consecutively acquired the genes responsible for capsule synthesis via horizontal gene transfer.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Schoen C, Blom J, Claus H, et al. Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3473-3478.
Schoen, C., Blom, J., Claus, H., Schramm-Glueck, A., Brandt, P., Mueller, T., Goesmann, A., et al. (2008). Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(9), 3473-3478. doi:10.1073/pnas.0800151105
Schoen, C., Blom, J., Claus, H., Schramm-Glueck, A., Brandt, P., Mueller, T., Goesmann, A., Joseph, B., Konietzny, S., Kurzai, O., et al. (2008). Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105, 3473-3478.
Schoen, C., et al., 2008. Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(9), p 3473-3478.
C. Schoen, et al., “Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105, 2008, pp. 3473-3478.
Schoen, C., Blom, J., Claus, H., Schramm-Glueck, A., Brandt, P., Mueller, T., Goesmann, A., Joseph, B., Konietzny, S., Kurzai, O., Schmitt, C., Friedrich, T., Linke, B., Vogel, U., Frosch, M.: Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 105, 3473-3478 (2008).
Schoen, Christoph, Blom, Jochen, Claus, Heike, Schramm-Glueck, Anja, Brandt, Petra, Mueller, Tobias, Goesmann, Alexander, Joseph, Biju, Konietzny, Sebastian, Kurzai, Oliver, Schmitt, Corinna, Friedrich, Torben, Linke, Burkhard, Vogel, Ulrich, and Frosch, Matthias. “Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis”. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105.9 (2008): 3473-3478.
This data publication is cited in the following publications:
This publication cites the following data publications:

99 Citations in Europe PMC

Data provided by Europe PubMed Central.

Genotypic diversity in Oenococcus oeni by high-density microarray comparative genome hybridization and whole genome sequencing.
Borneman AR, Bartowsky EJ, McCarthy J, Chambers PJ., Appl Microbiol Biotechnol 86(2), 2010
PMID: 20111862
A dual role of extracellular DNA during biofilm formation of Neisseria meningitidis.
Lappann M, Claus H, van Alen T, Harmsen M, Elias J, Molin S, Vogel U., Mol Microbiol 75(6), 2010
PMID: 20180907
Biofilm formation by the human pathogen Neisseria meningitidis.
Lappann M, Vogel U., Med Microbiol Immunol 199(3), 2010
PMID: 20376486
A computational genomics pipeline for prokaryotic sequencing projects.
Kislyuk AO, Katz LS, Agrawal S, Hagen MS, Conley AB, Jayaraman P, Nelakuditi V, Humphrey JC, Sammons SA, Govil D, Mair RD, Tatti KM, Tondella ML, Harcourt BH, Mayer LW, Jordan IK., Bioinformatics 26(15), 2010
PMID: 20519285
Expression of the meningococcal adhesin NadA is controlled by a transcriptional regulator of the MarR family.
Schielke S, Huebner C, Spatz C, Nägele V, Ackermann N, Frosch M, Kurzai O, Schubert-Unkmeir A., Mol Microbiol 72(4), 2009
PMID: 19400792
Metagenomic analysis of stressed coral holobionts.
Vega Thurber R, Willner-Hall D, Rodriguez-Mueller B, Desnues C, Edwards RA, Angly F, Dinsdale E, Kelly L, Rohwer F., Environ Microbiol 11(8), 2009
PMID: 19397678
Differential modulation of TNF-alpha-induced apoptosis by Neisseria meningitidis.
Deghmane AE, Veckerlé C, Giorgini D, Hong E, Ruckly C, Taha MK., PLoS Pathog 5(5), 2009
PMID: 19412525
Evidence for capsule switching between carried and disease-causing Neisseria meningitidis strains.
Beddek AJ, Li MS, Kroll JS, Jordan TW, Martin DR., Infect Immun 77(7), 2009
PMID: 19451248
EDGAR: a software framework for the comparative analysis of prokaryotic genomes.
Blom J, Albaum SP, Doppmeier D, Pühler A, Vorhölter FJ, Zakrzewski M, Goesmann A., BMC Bioinformatics 10(), 2009
PMID: 19457249
Meningococcal carriage and disease--population biology and evolution.
Caugant DA, Maiden MC., Vaccine 27 Suppl 2(), 2009
PMID: 19464092
Genome flexibility in Neisseria meningitidis.
Schoen C, Tettelin H, Parkhill J, Frosch M., Vaccine 27 Suppl 2(), 2009
PMID: 19477564
Influenza A virus neuraminidase enhances meningococcal adhesion to epithelial cells through interaction with sialic acid-containing meningococcal capsules.
Rameix-Welti MA, Zarantonelli ML, Giorgini D, Ruckly C, Marasescu M, van der Werf S, Alonso JM, Naffakh N, Taha MK., Infect Immun 77(9), 2009
PMID: 19528219
Role of the type III secretion system in a hypervirulent lineage of Bordetella bronchiseptica.
Buboltz AM, Nicholson TL, Weyrich LS, Harvill ET., Infect Immun 77(9), 2009
PMID: 19596779
Lateral genetic transfer: open issues.
Ragan MA, Beiko RG., Philos Trans R Soc Lond B Biol Sci 364(1527), 2009
PMID: 19571244
NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis.
Rusniok C, Vallenet D, Floquet S, Ewles H, Mouzé-Soulama C, Brown D, Lajus A, Buchrieser C, Médigue C, Glaser P, Pelicic V., Genome Biol 10(10), 2009
PMID: 19818133
Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer.
Pearson T, Giffard P, Beckstrom-Sternberg S, Auerbach R, Hornstra H, Tuanyok A, Price EP, Glass MB, Leadem B, Beckstrom-Sternberg JS, Allan GJ, Foster JT, Wagner DM, Okinaka RT, Sim SH, Pearson O, Wu Z, Chang J, Kaul R, Hoffmaster AR, Brettin TS, Robison RA, Mayo M, Gee JE, Tan P, Currie BJ, Keim P., BMC Biol 7(), 2009
PMID: 19922616
Molecular characterization of erythromycin-resistant Streptococcus agalactiae strains.
Domelier AS, van der Mee-Marquet N, Arnault L, Mereghetti L, Lanotte P, Rosenau A, Lartigue MF, Quentin R., J Antimicrob Chemother 62(6), 2008
PMID: 18786936
Comparative genomics: the bacterial pan-genome.
Tettelin H, Riley D, Cattuto C, Medini D., Curr Opin Microbiol 11(5), 2008
PMID: 19086349
Population genomics: diversity and virulence in the Neisseria.
Maiden MC., Curr Opin Microbiol 11(5), 2008
PMID: 18822386
Association of a bacteriophage with meningococcal disease in young adults.
Bille E, Ure R, Gray SJ, Kaczmarski EB, McCarthy ND, Nassif X, Maiden MC, Tinsley CR., PLoS One 3(12), 2008
PMID: 19065260

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 18305155
PubMed | Europe PMC

Search this title in

Google Scholar