Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics

Szczepanowski R, Linke B, Krahn I, Gartemann K-H, Guetzkow T, Eichler W, Pühler A, Schlueter A (2009)
MICROBIOLOGY 155(7): 2306-2319.

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Abstract / Bemerkung
To detect plasmid-borne antibiotic-resistance genes in wastewater treatment plant (WWTP) bacteria, 192 resistance-gene-specific PCR primer pairs were designed and synthesized. Subsequent PCR analyses on total plasmid DNA preparations obtained from bacteria of activated sludge or the WWTP's final effluents led to the identification of, respectively, 140 and 123 different resistance-gene-specific amplicons. The genes detected included aminoglycoside, beta-lactam, chloramphenicol, fluoroquinolone, macrolide, rifampicin, tetracycline, trimethoprim and sulfonamide resistance genes as well as multidrug efflux and small multidrug resistance genes. Some of these genes were only recently described from clinical isolates, demonstrating genetic exchange between clinical and WWTP bacteria. Sequencing of selected resistance-gene-specific amplicons confirmed their identity or revealed that the amplicon nucleotide sequence is very similar to a (gene closely related to the reference gene used for primer design. These results demonstrate that WWTP bacteria are a reservoir for various resistance genes. Moreover, detection of about 64% of the 192 reference resistance genes in bacteria obtained from the WWTP's final effluents indicates that these resistance determinants might be further disseminated in habitats downstream of the sewage plant.
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MICROBIOLOGY
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155
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7
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2306-2319
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Szczepanowski R, Linke B, Krahn I, et al. Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. MICROBIOLOGY. 2009;155(7):2306-2319.
Szczepanowski, R., Linke, B., Krahn, I., Gartemann, K. - H., Guetzkow, T., Eichler, W., Pühler, A., et al. (2009). Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. MICROBIOLOGY, 155(7), 2306-2319. doi:10.1099/mic.0.028233-0
Szczepanowski, R., Linke, B., Krahn, I., Gartemann, K. - H., Guetzkow, T., Eichler, W., Pühler, A., and Schlueter, A. (2009). Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. MICROBIOLOGY 155, 2306-2319.
Szczepanowski, R., et al., 2009. Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. MICROBIOLOGY, 155(7), p 2306-2319.
R. Szczepanowski, et al., “Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics”, MICROBIOLOGY, vol. 155, 2009, pp. 2306-2319.
Szczepanowski, R., Linke, B., Krahn, I., Gartemann, K.-H., Guetzkow, T., Eichler, W., Pühler, A., Schlueter, A.: Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. MICROBIOLOGY. 155, 2306-2319 (2009).
Szczepanowski, Rafael, Linke, Burkhard, Krahn, Irene, Gartemann, Karl-Heinz, Guetzkow, Tim, Eichler, Wolfgang, Pühler, Alfred, and Schlueter, Andreas. “Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics”. MICROBIOLOGY 155.7 (2009): 2306-2319.

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IncP-1-beta plasmid pGNB1 isolated from a bacterial community from a wastewater treatment plant mediates decolorization of triphenylmethane dyes.
Schluter A, Krahn I, Kollin F, Bonemann G, Stiens M, Szczepanowski R, Schneiker S, Puhler A., Appl. Environ. Microbiol. 73(20), 2007
PMID: 17675426
Genetic diversity and composition of a plasmid metagenome from a wastewater treatment plant.
Schluter A, Krause L, Szczepanowski R, Goesmann A, Puhler A., J. Biotechnol. 136(1-2), 2008
PMID: 18603322

AUTHOR UNKNOWN, REV MED MICROBIOL 13(), 2002
Quantification of tetracycline resistance genes in feedlot lagoons by real-time PCR.
Smith MS, Yang RK, Knapp CW, Niu Y, Peak N, Hanfelt MM, Galland JC, Graham DW., Appl. Environ. Microbiol. 70(12), 2004
PMID: 15574938
Comparative genomic hybridisation and ultrafast pyrosequencing revealed remarkable differences between the Sinorhizobium meliloti genomes of the model strain Rm1021 and the field isolate SM11.
Stiens M, Becker A, Bekel T, Godde V, Goesmann A, Niehaus K, Schneiker-Bekel S, Selbitschka W, Weidner S, Schluter A, Puhler A., J. Biotechnol. 136(1-2), 2008
PMID: 18562031
Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant.
Szczepanowski R, Krahn I, Bohn N, Puhler A, Schluter A., Antimicrob. Agents Chemother. 51(2), 2006
PMID: 17101677
Insight into the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to antimicrobial drugs analysed by the 454-pyrosequencing technology.
Szczepanowski R, Bekel T, Goesmann A, Krause L, Kromeke H, Kaiser O, Eichler W, Puhler A, Schluter A., J. Biotechnol. 136(1-2), 2008
PMID: 18586057
Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant.
Tennstedt T, Szczepanowski R, Braun S, Puhler A, Schluter A., FEMS Microbiol. Ecol. 45(3), 2003
PMID: 19719593

AUTHOR UNKNOWN, Plasmid 53(), 2005
Detection of clinically relevant antibiotic-resistance genes in municipal wastewater using real-time PCR (TaqMan).
Volkmann H, Schwartz T, Bischoff P, Kirchen S, Obst U., J. Microbiol. Methods 56(2), 2004
PMID: 14744456
Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.
Vourli S, Giakkoupi P, Miriagou V, Tzelepi E, Vatopoulos AC, Tzouvelekis LS., FEMS Microbiol. Lett. 234(2), 2004
PMID: 15135524
bla(IMP-9) and its association with large plasmids carried by Pseudomonas aeruginosa isolates from the People's Republic of China.
Xiong J, Hynes MF, Ye H, Chen H, Yang Y, M'zali F, Hawkey PM., Antimicrob. Agents Chemother. 50(1), 2006
PMID: 16377710

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