Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart

Gawlowski T, Stratmann B, Stork I, Engelbrecht B, Brodehl A, Niehaus K, Koerfer R, Tschoepe D, Milting H (2009)
Hormone and Metabolic Research 41(08): 594-599.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ;
Abstract
Chronic conditions like diabetes mellitus (DM) leading to altered metabolism might cause cardiac dysfunction. Hyperglycemia plays an important role in the pathogenesis of diabetic complications including accumulation of methylglyoxal (MG), a highly reactive alpha-dicarbonyl metabolite of glucose degradation pathways and increased generation of advanced glycation endproducts (AGEs). The aim of this investigation was to study the extent of the MG-modification argpyrimidine in human diabetic heart and in rat cardiomyoblasts grown under hyperglycemic conditions. Left ventricular myocardial samples from explanted hearts of patients with cardiomyopathy with (n=8) or without DM (n=8) as well as nonfailing donor organs (n=6), and rat cardiac myoblasts H9c2 treated with glucose were screened for the MG-modification argpyrimidine. The small heat shock protein 27 (Hsp27) revealed to be the major argpyrimidine containing protein in cardiac tissue. Additionally, the modification of arginine leading to argpyrimidine and the phosphorylation of Hsp27 are increased in the myocardium of patients with DM. In H9c2 cells hyperglycemia leads to a decrease of the Hsp27-expression and an increase in argpyrimidine content and phosphorylation of Hsp27, which was accompanied by the induction of oxidative stress and apoptosis. This study shows an association between diabetes and increased argpyrimidine-modification of myocardial Hsp27, a protein which is involved in apoptosis, oxidative stress, and cytoskeleton stabilization.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Gawlowski T, Stratmann B, Stork I, et al. Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research. 2009;41(08):594-599.
Gawlowski, T., Stratmann, B., Stork, I., Engelbrecht, B., Brodehl, A., Niehaus, K., Koerfer, R., et al. (2009). Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research, 41(08), 594-599.
Gawlowski, T., Stratmann, B., Stork, I., Engelbrecht, B., Brodehl, A., Niehaus, K., Koerfer, R., Tschoepe, D., and Milting, H. (2009). Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research 41, 594-599.
Gawlowski, T., et al., 2009. Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research, 41(08), p 594-599.
T. Gawlowski, et al., “Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart”, Hormone and Metabolic Research, vol. 41, 2009, pp. 594-599.
Gawlowski, T., Stratmann, B., Stork, I., Engelbrecht, B., Brodehl, A., Niehaus, K., Koerfer, R., Tschoepe, D., Milting, H.: Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart. Hormone and Metabolic Research. 41, 594-599 (2009).
Gawlowski, T., Stratmann, B., Stork, I., Engelbrecht, B., Brodehl, A., Niehaus, Karsten, Koerfer, R., Tschoepe, D., and Milting, H. “Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart”. Hormone and Metabolic Research 41.08 (2009): 594-599.
This data publication is cited in the following publications:
This publication cites the following data publications:

7 Citations in Europe PMC

Data provided by Europe PubMed Central.

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity.
Luo X, Wu J, Jing S, Yan LJ., Aging Dis 7(1), 2016
PMID: 26816666
The Use of SGLT-2 Inhibitors in Type 2 Diabetes and Heart Failure.
Riggs K, Ali H, Taegtmeyer H, Gutierrez AD., Metab Syndr Relat Disord 13(7), 2015
PMID: 26125313
The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases.
Maessen DE, Stehouwer CD, Schalkwijk CG., Clin. Sci. 128(12), 2015
PMID: 25818485
Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure.
Dei Cas A, Khan SS, Butler J, Mentz RJ, Bonow RO, Avogaro A, Tschoepe D, Doehner W, Greene SJ, Senni M, Gheorghiade M, Fonarow GC., JACC Heart Fail 3(2), 2015
PMID: 25660838
Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts.
Engelbrecht B, Stratmann B, Hess C, Tschoepe D, Gawlowski T., PLoS ONE 8(5), 2013
PMID: 23717693
Diabetic cardiomyopathy--to take a long story serious.
Stratmann B, Gawlowski T, Tschoepe D., Herz 35(3), 2010
PMID: 20467928

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 19384818
PubMed | Europe PMC

Search this title in

Google Scholar