Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons

Kurtz R, Beckers U, Hundsdoerfer B, Egelhaaf M (2009)
European Journal of Neuroscience 30(4): 567-577.

Download
OA 1.96 MB
Journal Article | Published | English
Author
; ; ;
Abstract
In many neurons, strong excitatory stimulation causes an after-hyperpolarization (AHP) at stimulus offset, which might give rise to activity-dependent adaptation. Graded-potential visual motion-sensitive neurons of the fly Calliphora vicina respond with depolarization and hyperpolarization during motion in their preferred direction and their anti-preferred direction, respectively. A prominent after-response, opposite in sign to the response during motion, is selectively expressed after stimulation with preferred-direction motion. Previous findings suggested that this AHP is generated in the motion-sensitive neurons themselves rather than in presynaptic processing layers. However, it remained unknown whether the AHP is caused by membrane depolarization itself or by another process, e.g. a signaling cascade triggered by activity of excitatory input channels. Here we showed by current injections and voltage clamp that the AHP and a corresponding current are generated directly by depolarization. To test whether the generation of an AHP is linked to depolarization via a Ca(2+)-dependent mechanism, we used photoactivation of a high-affinity Ca(2+) buffer. In accordance with previous findings the AHP was insensitive to manipulation of cytosolic Ca(2+). We propose that membrane depolarization presents a more direction-selective mechanism for the control of AHP than other potential control parameters.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Kurtz R, Beckers U, Hundsdoerfer B, Egelhaaf M. Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience. 2009;30(4):567-577.
Kurtz, R., Beckers, U., Hundsdoerfer, B., & Egelhaaf, M. (2009). Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience, 30(4), 567-577. doi:10.1111/j.1460-9568.2009.06854.x
Kurtz, R., Beckers, U., Hundsdoerfer, B., and Egelhaaf, M. (2009). Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience 30, 567-577.
Kurtz, R., et al., 2009. Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience, 30(4), p 567-577.
R. Kurtz, et al., “Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons”, European Journal of Neuroscience, vol. 30, 2009, pp. 567-577.
Kurtz, R., Beckers, U., Hundsdoerfer, B., Egelhaaf, M.: Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons. European Journal of Neuroscience. 30, 567-577 (2009).
Kurtz, Rafael, Beckers, Ulrich, Hundsdoerfer, Benjamin, and Egelhaaf, Martin. “Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons”. European Journal of Neuroscience 30.4 (2009): 567-577.
Main File(s)
Access Level
OA Open Access
Last Uploaded
2016-05-25T09:34:49Z

This data publication is cited in the following publications:
This publication cites the following data publications:

1 Citation in Europe PMC

Data provided by Europe PubMed Central.

59 References

Data provided by Europe PubMed Central.

Cellular mechanisms of long-lasting adaptation in visual cortical neurons in vitro.
Sanchez-Vives MV, Nowak LG, McCormick DA., J. Neurosci. 20(11), 2000
PMID: 10818164
Different mechanisms of calcium entry within different dendritic compartments.
Single S, Borst A., J. Neurophysiol. 87(3), 2002
PMID: 11877530
Dendritic computation of direction selectivity and gain control in visual interneurons.
Single S, Haag J, Borst A., J. Neurosci. 17(16), 1997
PMID: 9236213
Lobula plate and ocellar interneurons converge onto a cluster of descending neurons leading to neck and leg motor neuropil in Calliphora erythrocephala
Strausfeld, Cell Tissue Res. 240(), 1985
Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels.
Vahasoyrinki M, Niven JE, Hardie RC, Weckstrom M, Juusola M., J. Neurosci. 26(10), 2006
PMID: 16525044
A Drosophila KCNQ channel essential for early embryonic development.
Wen H, Weiger TM, Ferguson TS, Shahidullah M, Scott SS, Levitan IB., J. Neurosci. 25(44), 2005
PMID: 16267222

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 19674090
PubMed | Europe PMC

Search this title in

Google Scholar