Interferon-beta modulates protein synthesis in the central nervous system

Beyer S, Raether G, Stadler K, Hoffrogge R, Scharf C, Rolfs A, Mix E, Strauss U (2009)
JOURNAL OF NEUROIMMUNOLOGY 213(1-2): 31-38.

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Abstract
Interferon-beta (IFN-beta), acting canonically via the modulation of transcription, affects neocortical pyramidal neurons. By use of 2-D differential gel electrophoresis and subsequent mass spectrometry we identified IFN-beta regulated proteins in the central nervous system. These proteins are involved in cytoskeleton assembly, protein transport and nucleotide metabolism and, as such, serve regenerative and protective functions. Electrophysiologically, IFN-beta mediated protein synthesis is essential for part of the excitatory neuronal effects, as revealed under blockade of protein biosynthesis. This study presents novel effects of IFN-beta in the central nervous system and begins to unravel the mechanism behind the known excitability changes in neurons. (C) 2009 Elsevier B.V. All rights reserved.
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Beyer S, Raether G, Stadler K, et al. Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY. 2009;213(1-2):31-38.
Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., et al. (2009). Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY, 213(1-2), 31-38.
Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., and Strauss, U. (2009). Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY 213, 31-38.
Beyer, S., et al., 2009. Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY, 213(1-2), p 31-38.
S. Beyer, et al., “Interferon-beta modulates protein synthesis in the central nervous system”, JOURNAL OF NEUROIMMUNOLOGY, vol. 213, 2009, pp. 31-38.
Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., Strauss, U.: Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY. 213, 31-38 (2009).
Beyer, Susanne, Raether, Gergana, Stadler, Konstantin, Hoffrogge, Raimund, Scharf, Christian, Rolfs, Arndt, Mix, Eilhard, and Strauss, Ulf. “Interferon-beta modulates protein synthesis in the central nervous system”. JOURNAL OF NEUROIMMUNOLOGY 213.1-2 (2009): 31-38.
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Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations.
Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, Schuchmann S, Velmans T, Rosenberger K, Brauer AU, Lehnardt S, Nitsch R, Budt M, Wolff T, Kole MH, Strauss U., Cereb. Cortex 24(1), 2014
PMID: 23042740

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