Positioning system for particles in microfluidic structures

Weddemann A, Wittbracht F, Auge A, Hütten A (2009)
MICROFLUIDICS AND NANOFLUIDICS 7(6): 849-855.

Journal Article | Published | English

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Abstract
Fast continuous flow detection of biomolecules in lab-on-a-chip structures is a challenging task. Combining these molecules with small magnetic particles, the interaction between their stray field and, e.g., magneto-resistive sensors can be used to indirectly prove the biomolecules. To position the particles on top of a sensor array at the bottom of the flow channel, we propose a microfluidic structure of changing channel height combining hydrodynamic and gravitational effects. We present numerical calculations predicting an increase in the capture rate by more than 100% in comparison to a straight channel. We experimentally realize an optical analysis of the specific binding of biotin-functionalized Chemagen beads on a streptavidin-coated surface. To prove the binding is not due to the surface effects, a second uncoated bead species is employed.
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Weddemann A, Wittbracht F, Auge A, Hütten A. Positioning system for particles in microfluidic structures. MICROFLUIDICS AND NANOFLUIDICS. 2009;7(6):849-855.
Weddemann, A., Wittbracht, F., Auge, A., & Hütten, A. (2009). Positioning system for particles in microfluidic structures. MICROFLUIDICS AND NANOFLUIDICS, 7(6), 849-855.
Weddemann, A., Wittbracht, F., Auge, A., and Hütten, A. (2009). Positioning system for particles in microfluidic structures. MICROFLUIDICS AND NANOFLUIDICS 7, 849-855.
Weddemann, A., et al., 2009. Positioning system for particles in microfluidic structures. MICROFLUIDICS AND NANOFLUIDICS, 7(6), p 849-855.
A. Weddemann, et al., “Positioning system for particles in microfluidic structures”, MICROFLUIDICS AND NANOFLUIDICS, vol. 7, 2009, pp. 849-855.
Weddemann, A., Wittbracht, F., Auge, A., Hütten, A.: Positioning system for particles in microfluidic structures. MICROFLUIDICS AND NANOFLUIDICS. 7, 849-855 (2009).
Weddemann, A., Wittbracht, F., Auge, A., and Hütten, Andreas. “Positioning system for particles in microfluidic structures”. MICROFLUIDICS AND NANOFLUIDICS 7.6 (2009): 849-855.
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