Induction of DNA Breakage in U937 Cells by Oxazaphosphorines

Mazur L, Opydo-Chanek M, Stojak M, Baran J, Niemeyer, IIT-GmbH U (2010)
FOLIA BIOLOGICA-KRAKOW 58(1): 15-20.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ;
Abstract / Bemerkung
Oxazaphosphorines are a class of DNA alkylating agents. The aim of the present study was to compare the possible influence of three new generation oxazaphosphorines, D-17272 (mafosfamide cyclohexylamine salt), D-18864 (4-hydro-peroxy-cyclophosphamide), and D-19575 (glufosfamide, P-D-glucose-isophosphoramide mustard) on DNA damage induction in the human histiocytic lymphoma U937 cells. The flow cytometry APO-BRDU (TM) assay, based on the TUNEL method, was used for the in situ detection of DNA strand breaks. After exposure of U937 cells to the oxazaphosphorines, the patterns of temporary changes in the frequency of TUNEL positive U937 cells, expressing DNA breakage, were determined. The effects of the oxazaphosphorines on U937 cells were dependent on the agent tested and its dose, and the time intervals after the drug application. The different potential of D-I 7272, D-18864 and D-19575 to induce DNA strand breakage in the human histiocytic lymphoma U937 cells was shown.
Erscheinungsjahr
Zeitschriftentitel
FOLIA BIOLOGICA-KRAKOW
Band
58
Zeitschriftennummer
1
Seite
15-20
ISSN
eISSN
PUB-ID

Zitieren

Mazur L, Opydo-Chanek M, Stojak M, Baran J, Niemeyer, IIT-GmbH U. Induction of DNA Breakage in U937 Cells by Oxazaphosphorines. FOLIA BIOLOGICA-KRAKOW. 2010;58(1):15-20.
Mazur, L., Opydo-Chanek, M., Stojak, M., Baran, J., & Niemeyer, IIT-GmbH, U. (2010). Induction of DNA Breakage in U937 Cells by Oxazaphosphorines. FOLIA BIOLOGICA-KRAKOW, 58(1), 15-20. doi:10.3409/fb58_1-2.15-20
Mazur, L., Opydo-Chanek, M., Stojak, M., Baran, J., and Niemeyer, IIT-GmbH, U. (2010). Induction of DNA Breakage in U937 Cells by Oxazaphosphorines. FOLIA BIOLOGICA-KRAKOW 58, 15-20.
Mazur, L., et al., 2010. Induction of DNA Breakage in U937 Cells by Oxazaphosphorines. FOLIA BIOLOGICA-KRAKOW, 58(1), p 15-20.
L. Mazur, et al., “Induction of DNA Breakage in U937 Cells by Oxazaphosphorines”, FOLIA BIOLOGICA-KRAKOW, vol. 58, 2010, pp. 15-20.
Mazur, L., Opydo-Chanek, M., Stojak, M., Baran, J., Niemeyer, IIT-GmbH, U.: Induction of DNA Breakage in U937 Cells by Oxazaphosphorines. FOLIA BIOLOGICA-KRAKOW. 58, 15-20 (2010).
Mazur, Lidia, Opydo-Chanek, Malgorzata, Stojak, Marta, Baran, Jaroslaw, and Niemeyer, IIT-GmbH, Ulf. “Induction of DNA Breakage in U937 Cells by Oxazaphosphorines”. FOLIA BIOLOGICA-KRAKOW 58.1 (2010): 15-20.

1 Zitation in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Glufosfamide as a new oxazaphosphorine anticancer agent.
Mazur L, Opydo-Chanek M, Stojak M., Anticancer Drugs 22(6), 2011
PMID: 21427562

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 20420190
PubMed | Europe PMC

Suchen in

Google Scholar