Neural stem cells, inflammation and NF-kappa B: basic principle of maintenance and repair or origin of brain tumours ?

Widera D, Kaus A, Kaltschmidt C, Kaltschmidt B (2008)
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12(2): 459-470.

Download
No fulltext has been uploaded. References only!
Journal Article | Review | Published | English

No fulltext has been uploaded

Abstract
Several recent reports suggest that inflammatory signals play a decisive role in the self-renewal, migration and differentiation of multipotent neural stem cells (NSCs). NSCs are believed to be able to ameliorate the symptoms of several brain pathologies through proliferation, migration into the area of the lesion and either differentiation into the appropriate cell type or secretion of anti-inflammatory cytokines. Although NSCs have beneficial roles, current evidence indicates that brain tumours, such as astrogliomas or ependymomas are also caused by tumour-initiating cells with stem-like properties. However, little is known about the cellular and molecular processes potentially generating tumours from NSCs. Most pro-inflammatory conditions are considered to activate the transcription factor NF-kappa B in various cell types. Strong inductive effects of NF-kappa B on proliferation and migration of NSCs have been described. Moreover, NF-kappa B is constitutively active in most tumour cells described so far. Chronic inflammation is also known to initiate cancer. Thus, NF-kappa B might provide a novel mechanistic link between chronic inflammation, stem cells and cancer. This review discusses the apparently ambivalent role of NF-kappa B: physiological maintenance and repair of the brain via NSCs, and a potential role in tumour initiation. Furthermore, it reveals a possible mechanism of brain tumour formation based on inflammation and NF-kappa B activity in NSCs.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Widera D, Kaus A, Kaltschmidt C, Kaltschmidt B. Neural stem cells, inflammation and NF-kappa B: basic principle of maintenance and repair or origin of brain tumours ? JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2008;12(2):459-470.
Widera, D., Kaus, A., Kaltschmidt, C., & Kaltschmidt, B. (2008). Neural stem cells, inflammation and NF-kappa B: basic principle of maintenance and repair or origin of brain tumours ? JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 12(2), 459-470. doi:10.1111/j.1582-4934.2007.00208.x
Widera, D., Kaus, A., Kaltschmidt, C., and Kaltschmidt, B. (2008). Neural stem cells, inflammation and NF-kappa B: basic principle of maintenance and repair or origin of brain tumours ? JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12, 459-470.
Widera, D., et al., 2008. Neural stem cells, inflammation and NF-kappa B: basic principle of maintenance and repair or origin of brain tumours ? JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 12(2), p 459-470.
D. Widera, et al., “Neural stem cells, inflammation and NF-kappa B: basic principle of maintenance and repair or origin of brain tumours ?”, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 12, 2008, pp. 459-470.
Widera, D., Kaus, A., Kaltschmidt, C., Kaltschmidt, B.: Neural stem cells, inflammation and NF-kappa B: basic principle of maintenance and repair or origin of brain tumours ? JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 12, 459-470 (2008).
Widera, Darius, Kaus, A., Kaltschmidt, Christian, and Kaltschmidt, Barbara. “Neural stem cells, inflammation and NF-kappa B: basic principle of maintenance and repair or origin of brain tumours ?”. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12.2 (2008): 459-470.
This data publication is cited in the following publications:
This publication cites the following data publications:

29 Citations in Europe PMC

Data provided by Europe PubMed Central.

Selection of multipotent cells and enhanced muscle reconstruction by myogenic macrophage-secreted factors.
Malerba A, Vitiello L, Segat D, Dazzo E, Frigo M, Scambi I, De Coppi P, Boldrin L, Martelli L, Pasut A, Romualdi C, Bellomo RG, Vecchiet J, Baroni MD., Exp Cell Res 315(6), 2009
PMID: 19371636
Therapeutic strategies for inhibiting invasion in glioblastoma.
Drappatz J, Norden AD, Wen PY., Expert Rev Neurother 9(4), 2009
PMID: 19344303

125 References

Data provided by Europe PubMed Central.

Expression of Ki-67, topoisomerase IIalpha and c-MYC in astrocytic tumors: correlation with the histopathological grade and proliferative status.
Faria MH, Goncalves BP, do Patrocinio RM, de Moraes-Filho MO, Rabenhorst SH., Neuropathology 26(6), 2006
PMID: 17203587
Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas.
Eberhart CG, Kratz JE, Schuster A, Goldthwaite P, Cohen KJ, Perlman EJ, Burger PC., Brain Pathol. 12(1), 2002
PMID: 11770900
Large cell/anaplastic medulloblastomas and medullomyoblastomas: clinicopathological and genetic features.
Leonard JR, Cai DX, Rivet DJ, Kaufman BA, Park TS, Levy BK, Perry A., J. Neurosurg. 95(1), 2001
PMID: 11453402
Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.
Eberhart CG, Kratz J, Wang Y, Summers K, Stearns D, Cohen K, Dang CV, Burger PC., J. Neuropathol. Exp. Neurol. 63(5), 2004
PMID: 15198123
MYC expression promotes the proliferation of neural progenitor cells in culture and in vivo.
Fults D, Pedone C, Dai C, Holland EC., Neoplasia 4(1), 2002
PMID: 11922389
Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation.
Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart CG, Majumder S., Mol. Cell. Biol. 26(5), 2006
PMID: 16478988
c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice.
Rao G, Pedone CA, Coffin CM, Holland EC, Fults DW., Neoplasia 5(3), 2003
PMID: 12869303
Significance of cyclin D1 expression in meningiomas: a preliminary study.
Alama A, Barbieri F, Spaziante R, Bruzzo C, Dadati P, Dorcaratto A, Ravetti JL., J Clin Neurosci 14(4), 2007
PMID: 17240151
Expression of human telomerase reverse transcriptase and cyclin-D1 in olfactory neuroblastoma.
Wang SL, Chen WT, Li SH, Li SW, Yang SF, Chai CY., APMIS 115(1), 2007
PMID: 17223847
Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation.
Pogoriler J, Millen K, Utset M, Du W., Development 133(19), 2006
PMID: 16943274
Chemoprevention of cancer and cardiovascular disease by resveratrol.
Lin JK, Tsai SH., Proc. Natl. Sci. Counc. Repub. China B 23(3), 1999
PMID: 10492890
Glucocorticoid hormones decrease proliferation of embryonic neural stem cells through ubiquitin-mediated degradation of cyclin D1.
Sundberg M, Savola S, Hienola A, Korhonen L, Lindholm D., J. Neurosci. 26(20), 2006
PMID: 16707792
The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors.
El Wakil A, Francius C, Wolff A, Pleau-Varet J, Nardelli J., Development 133(11), 2006
PMID: 16672344
Chemotherapy resistance of glioblastoma stem cells.
Eramo A, Ricci-Vitiani L, Zeuner A, Pallini R, Lotti F, Sette G, Pilozzi E, Larocca LM, Peschle C, De Maria R., Cell Death Differ. 13(7), 2006
PMID: 16456578
Role of ABC transporters in the chemoresistance of human gliomas.
Decleves X, Amiel A, Delattre JY, Scherrmann JM., Curr Cancer Drug Targets 6(5), 2006
PMID: 16918310
Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2.
Lepper ER, Nooter K, Verweij J, Acharya MR, Figg WD, Sparreboom A., Pharmacogenomics 6(2), 2005
PMID: 15882131
Regional variations in ABC transporter expression along the mouse intestinal tract.
Mutch DM, Anderle P, Fiaux M, Mansourian R, Vidal K, Wahli W, Williamson G, Roberts MA., Physiol. Genomics 17(1), 2004
PMID: 14679303
A side order of stem cells: the SP phenotype.
Challen GA, Little MH., Stem Cells 24(1), 2006
PMID: 16449630
SP analysis may be used to identify cancer stem cell populations.
Hadnagy A, Gaboury L, Beaulieu R, Balicki D., Exp. Cell Res. 312(19), 2006
PMID: 17046749
ABC transporters, neural stem cells and neurogenesis--a different perspective.
Lin T, Islam O, Heese K., Cell Res. 16(11), 2006
PMID: 17088897
Effects of hypoxia on the proliferation and differentiation of NSCs.
Zhu LL, Wu LY, Yew DT, Fan M., Mol. Neurobiol. 31(1-3), 2005
PMID: 15953824
Proliferation and neuronal differentiation of mitotically active cells following traumatic brain injury.
Rice AC, Khaldi A, Harvey HB, Salman NJ, White F, Fillmore H, Bullock MR., Exp. Neurol. 183(2), 2003
PMID: 14552881

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 18182066
PubMed | Europe PMC

Search this title in

Google Scholar