Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects

Labudda K, Woermann FG, Mertens M, Pohlmann-Eden B, Markowitsch HJ, Brand M (2008)
EXPERIMENTAL BRAIN RESEARCH 187(4): 641-650.

Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ;
Abstract
Recent functional neuroimaging and lesion studies demonstrate the involvement of the orbitofrontal/ventromedial prefrontal cortex as a key structure in decision making processes. This region seems to be particularly crucial when contingencies between options and consequences are unknown but have to be learned by the use of feedback following previous decisions (decision making under ambiguity). However, little is known about the neural correlates of decision making under risk conditions in which information about probabilities and potential outcomes is given. In the present study, we used functional magnetic resonance imaging to measure blood-oxygenation-level-dependent (BOLD) responses in 12 subjects during a decision making task. This task provided explicit information about probabilities and associated potential incentives. The responses were compared to BOLD signals in a control condition without information about incentives. In contrast to previous decision making studies, we completely removed the outcome phase following a decision to exclude the potential influence of feedback previously received on current decisions. The results indicate that the integration of information about probabilities and incentives leads to activations within the dorsolateral prefrontal cortex, the posterior parietal lobe, the anterior cingulate and the right lingual gyrus. We assume that this pattern of activation is due to the involvement of executive functions, conflict detection mechanisms and arithmetic operations during the deliberation phase of decisional processes that are based on explicit information.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Labudda K, Woermann FG, Mertens M, Pohlmann-Eden B, Markowitsch HJ, Brand M. Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects. EXPERIMENTAL BRAIN RESEARCH. 2008;187(4):641-650.
Labudda, K., Woermann, F. G., Mertens, M., Pohlmann-Eden, B., Markowitsch, H. J., & Brand, M. (2008). Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects. EXPERIMENTAL BRAIN RESEARCH, 187(4), 641-650.
Labudda, K., Woermann, F. G., Mertens, M., Pohlmann-Eden, B., Markowitsch, H. J., and Brand, M. (2008). Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects. EXPERIMENTAL BRAIN RESEARCH 187, 641-650.
Labudda, K., et al., 2008. Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects. EXPERIMENTAL BRAIN RESEARCH, 187(4), p 641-650.
K. Labudda, et al., “Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects”, EXPERIMENTAL BRAIN RESEARCH, vol. 187, 2008, pp. 641-650.
Labudda, K., Woermann, F.G., Mertens, M., Pohlmann-Eden, B., Markowitsch, H.J., Brand, M.: Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects. EXPERIMENTAL BRAIN RESEARCH. 187, 641-650 (2008).
Labudda, Kirsten, Woermann, Friedrich G., Mertens, Markus, Pohlmann-Eden, Bernd, Markowitsch, Hans J., and Brand, Matthias. “Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects”. EXPERIMENTAL BRAIN RESEARCH 187.4 (2008): 641-650.
This data publication is cited in the following publications:
This publication cites the following data publications:

26 Citations in Europe PMC

Data provided by Europe PubMed Central.

71 References

Data provided by Europe PubMed Central.

Microstimulation of the dorsolateral prefrontal cortex biases saccade target selection.
Opris I, Barborica A, Ferrera VP., J Cogn Neurosci 17(6), 2005
PMID: 15969908
Decreased activation of anterior cingulate cortex in the working memory of the elderly.
Otsuka Y, Osaka N, Morishita M, Kondo H, Osaka M., Neuroreport 17(14), 2006
PMID: 16957592
Neuroanatomical substrates of arabic number processing, numerical comparison, and simple addition: a PET study.
Pesenti M, Thioux M, Seron X, De Volder A., J Cogn Neurosci 12(3), 2000
PMID: 10931772
Neural correlates of decision variables in parietal cortex.
Platt ML, Glimcher PW., Nature 400(6741), 1999
PMID: 10421364
Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms.
Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K, Baker NB, Hunter J, Carthy T, Booker E, London M, Deakin JF, Sahakian BJ, Robbins TW., Neuropsychopharmacology 20(4), 1999
PMID: 10088133

RD, J Neurosci 20(), 1999
Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition.
Rogers RD, Ramnani N, Mackay C, Wilson JL, Jezzard P, Carter CS, Smith SM., Biol. Psychiatry 55(6), 2004
PMID: 15013828
Decision-making in mania: a PET study.
Rubinsztein JS, Fletcher PC, Rogers RD, Ho LW, Aigbirhio FI, Paykel ES, Robbins TW, Sahakian BJ., Brain 124(Pt 12), 2001
PMID: 11701607
The differential involvement of inferior parietal lobule in number comparison: a rTMS study.
Sandrini M, Rossini PM, Miniussi C., Neuropsychologia 42(14), 2004
PMID: 15381020
Predictive reward signal of dopamine neurons.
Schultz W., J. Neurophysiol. 80(1), 1998
PMID: 9658025
Dissociation of neural systems mediating shifts in behavioral response and cognitive set.
Shafritz KM, Kartheiser P, Belger A., Neuroimage 25(2), 2005
PMID: 15784439
Understanding dissociations in dyscalculia: a brain imaging study of the impact of number size on the cerebral networks for exact and approximate calculation.
Stanescu-Cosson R, Pinel P, van De Moortele PF, Le Bihan D, Cohen L, Dehaene S., Brain 123 ( Pt 11)(), 2000
PMID: 11050024

AUTHOR UNKNOWN, 0
Cingulate cortex activation and competing responses: the role of preparedness for competition.
Suchan B, Melde C, Homberg V, Seitz RJ., Behav. Brain Res. 163(2), 2005
PMID: 16038990

J, 1988
Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making.
Tanabe J, Thompson L, Claus E, Dalwani M, Hutchison K, Banich MT., Hum Brain Mapp 28(12), 2007
PMID: 17274020
Cerebral processing of linguistic and emotional prosody: fMRI studies.
Wildgruber D, Ackermann H, Kreifelts B, Ethofer T., Prog. Brain Res. 156(), 2006
PMID: 17015084

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 18320179
PubMed | Europe PMC

Search this title in

Google Scholar